Orexin A in men with heroin use disorder undergoing methadone maintenance treatment.

Abstract:

:Orexins have played a role in reward-seeking and addiction-related behavior. There are few reports in the literature on serum levels of orexins in patients with heroin use disorder (HUD) undergoing methadone maintenance treatment (MMT). The aim of this study was to investigate the serum levels of orexin A in HUD patients undergoing MMT. Fifty male HUD patients undergoing MMT and 25 healthy males were enrolled for this study. Serum orexin A were measured with assay kits. Using analysis of covariance (ANCOVA) with body mass index (BMI) adjustments, the serum levels of orexin A in HUD men undergoing MMT were found to be significantly higher than in healthy controls. In conclusion, our results suggest that MMT might increase orexin A levels in HUD patients.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Tsai MC,Huang TL

doi

10.1016/j.psychres.2018.04.010

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

412-415

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(17)31908-X

journal_volume

264

pub_type

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