Abstract：
:Medication non-adherence is one of the major obstacles to recovery in first-episode psychosis (FEP). This study aimed to identify the predictors and rates of medication non-adherence in the first and second year after the start of treatment (baseline) in urban Chinese FEP patients. Relevant information on medication non-adherence and potential baseline predictors, including demographic variables, clinical measures, violence/suicide attempts, stressful life experiences, intervention received, and follow-up attendance, were collected from case records of 1400 FEP patients in Hong Kong. The non-adherence rate was 16.2% in year 1 and 15.4% in year 2. Regression analyses revealed the predictors for non-adherence in year 1 were no hospitalization at baseline, non-schizophrenia diagnosis, and more years of education. Predictors of non-adherence in year 2 included acute/subacute onset and older age of onset. Predictors common in both years were defaulting from psychiatric follow-up during baseline, standard psychiatric care (no early intervention), and lower positive symptoms severity at baseline. In assessing non-adherence risk and for planning phase-specific early interventions for FEP, particularly in a Chinese context, healthcare professionals should consider the common and specific predictors for non-adherence identified in the first and second years of treatment and should not overlook patients with less clinically severe symptoms.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Lai-Ming Hui C,Wing-Yan Poon V,Shuk-Kuen Kwok V,Chang WC,Kit-Wa Chan S,Ho-Ming Lee E,Yu-Hai Chen Edoi
10.1016/j.psychres.2015.04.047subject
Has Abstractpub_date
2015-08-30 00:00:00pages
680-7issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(15)00318-2journal_volume
228pub_type
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