Abstract：
:Structural and functional pathology of limbic structures including the hippocampus are frequently replicated in schizophrenia. Although the fornix is the main afferent system of the hippocampus to the septal nuclei and the hypothalamus (especially the mammillary bodies), relatively few studies have investigated structural changes of the fornix in schizophrenia. We measured the volume of the fornix in post-mortem brains in 19 patients with schizophrenia, 9 patients with bipolar disorder, 7 patients with unipolar depression, and 14 control subjects by planimetry of serial sections. The volumes, the mean cross-sectional areas, and the anterior to posterior distances of the fornix did not differ among patients with schizophrenia, bipolar disorder, unipolar depression, and control subjects. No lateralization existed between the right and the left fornices in among patients in the diagnostic groups and the control subjects. The fornix does not show morphometrical abnormalities in patients with schizophrenia, bipolar disorder and unipolar depression compared with control subjects, which might indicate that the fornix is not a primary focus of structural changes in these diseases.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Brisch R,Bernstein HG,Stauch R,Dobrowolny H,Krell D,Truebner K,Meyer-Lotz G,Bielau H,Steiner J,Kropf S,Gos T,Danos P,Bogerts Bdoi
10.1016/j.pscychresns.2007.12.007subject
Has Abstractpub_date
2008-12-30 00:00:00pages
265-73issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(07)00255-7journal_volume
164pub_type
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