Abstract:
:Preliminary data are presented on levels of plasma cortisol, dopamine (DA), epinephrine (EPI), and norepinephrine (NE) before and after dexamethasone in 22 depressed patients (of whom 4 were psychotic). Platelet monoamine oxidase (MAO) activity, determined in 19 of the depressed patients, was significantly higher in the 4 psychotic patients than it was in the 15 nonpsychotic patients. Positive correlations were observed before and after dexamethasone among cortisol, DA, EPI, and platelet MAO. After dexamethasone, plasma NE correlated negatively with DA, EPI, and cortisol. The various correlations were due largely to the inclusion of the psychotic depressive subgroup. Data are also presented on the relationships between these biological measures and specific signs and symptoms.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Schatzberg AF,Rothschild AJ,Langlais PJ,Lerbinger JE,Schildkraut JJ,Cole JOdoi
10.1016/0165-1781(87)90007-2subject
Has Abstractpub_date
1987-02-01 00:00:00pages
155-64issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(87)90007-2journal_volume
20pub_type
杂志文章abstract::Previous research showed that lowering the availability of serotonin to the brain by tryptophan depletion increases the vulnerability of panic disorder patients for an experimental 35% CO(2) panic challenge. The results also suggested that increased availability of serotonin inhibits the response to such a challenge. ...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychiatry research
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Psychiatry research
pub_type: 杂志文章,评审
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journal_title:Psychiatry research
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doi:10.1016/0165-1781(87)90122-3
更新日期:1987-01-01 00:00:00
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journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.06.019
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Psychiatry research
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journal_title:Psychiatry research
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更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychiatry research
pub_type: 杂志文章
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journal_title:Psychiatry research
pub_type: 杂志文章
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