Abstract：
:There have been conflicting findings as to whether the P3 brain potential to targets in oddball tasks is reduced in depressed patients. The P3 to novel distracter stimuli in a three-stimulus oddball task has a more frontocentral topography than P3 to targets and is associated with different cognitive operations and neural generators. The novelty P3 potential was predicted to be reduced in depressed patients. EEG was recorded from 30 scalp electrodes (nose reference) in 20 unmedicated depressed patients and 20 matched healthy controls during a novelty oddball task with three stimuli: infrequent target tones (12%), frequent standard tones (76%) and nontarget novel stimuli, e.g., animal or environment sounds (12%). Novel stimuli evoked a P3 potential with shorter peak latency and more frontocentral topography than the parietal-maximum P3b to target stimuli. The novelty P3 was markedly reduced in depressed patients compared to controls. Although there was a trend for patients to also have smaller parietal P3b to targets, this group difference was not statistically significant. Nor was there a group difference in the earlier N1 or N2 potentials. The novelty P3 reduction in depressed patients is indicative of a deficit in orienting of attention and evaluation of novel environmental sounds.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Bruder GE,Kroppmann CJ,Kayser J,Stewart JW,McGrath PJ,Tenke CEdoi
10.1016/j.psychres.2008.10.023subject
Has Abstractpub_date
2009-12-30 00:00:00pages
218-23issue
2-3eissn
0165-1781issn
1872-7123pii
S0165-1781(08)00386-7journal_volume
170pub_type
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