Abstract：
:Behavioral and biochemical studies in animals indicate that central dopaminergic neurotransmission may be modulated by sex steroids. This may be the mechanism underlying the suggested association between estrogen and schizophrenia. The aim was to examine if different levels of sex steroids during the menstrual cycle are associated with variations in D2 dopamine receptor density as measured with positron emission tomography (PET) and [11C]raclopride. Five healthy women were examined, one during two subsequent follicular phases and four during two different phases of their menstrual cycle. In none of the women did the difference in putamen to cerebellum (P/C) ratios (-11 to 10%) exceed the difference in P/C ratios previously reported in test-retest analyses in men (-11 to 9%). The findings do not support the conclusion that there is a menstrual-cycle-dependent variation in D2 receptor density detectable with single PET examinations and [11C]raclopride. Furthermore, a stable P/C ratio throughout the menstrual cycle indicated a stable D2 receptor occupancy in schizophrenic women treated with antipsychotic drugs. Repeated PET examinations of schizophrenic women known to deteriorate during particular phases of their menstrual cycle may further contribute to our understanding of the association between schizophrenia and sex steroids.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Nordström AL,Olsson H,Halldin Cdoi
10.1016/s0925-4927(98)00021-3subject
Has Abstractpub_date
1998-07-15 00:00:00pages
1-6issue
1eissn
0165-1781issn
1872-7123journal_volume
83pub_type
杂志文章abstract：:Low electro-oculographic (EOG) ratios have been reported in patients with seasonal affective disorder (SAD) during the winter. This study evaluated the effects of the changing seasons on EOG ratios in SAD patients. Sixteen outpatients with SAD and 16 age-, sex-, and medication-matched normal volunteers had EOG testing...
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(97)00024-3
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pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00216-x
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pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.02.013
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.08.002
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pub_type： 杂志文章
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更新日期：2009-05-15 00:00:00
abstract：:Adolescents with nonsuicidal self-injury (NSSI) have been described as having considerable impairment in social interactions, and social difficulties are often a trigger for NSSI. However, little is known about how adolescents with NSSI disorder process facial expressions of emotion. We investigated the recognition of...
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