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Electrophysiological evidence for primary semantic memory functional organization deficits in schizophrenia.

Abstract：

:N400, an event-related brain potential (ERP) waveform elicited by meaningful stimuli, is normally reduced by stimulus repetition (N400 repetition priming), and relatedness between the eliciting stimulus and preceding ones (relatedness priming). Schizophrenia patients' N400 relatedness priming deficits suggest impairment in using meaningful prime stimuli to facilitate processing of related concepts in semantic memory. To examine whether this deficiency arises from difficulty activating the prime concept per se, as indexed by reduced N400 repetition priming; or from impaired functional connections among concepts in semantic memory, as reflected by reduced relatedness priming but normal repetition priming; we recorded ERPs from 16 schizophrenia patients and 16 controls who viewed prime words each followed at 300- or 750-ms stimulus-onset asynchrony (SOA) by an unrelated, related or repeated target word, or a nonword, in a lexical-decision task. In both groups, N400s were largest (most negative) for unrelated, intermediate for related, and smallest for repeated targets. Schizophrenia patients exhibited subnormal N400 relatedness priming at the 300-ms SOA, but normal repetition priming at both SOAs, suggesting that their impairment in using prime words to activate related concepts results from abnormal functional connections among concepts within semantic memory, rather than inability to activate the prime concept itself.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Kiang M,Christensen BK,Kutas M,Zipursky RB

doi

10.1016/j.psychres.2012.02.026

subject

Has Abstract

pub_date

2012-04-30 00:00:00

pages

171-80

issue

2-3

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(12)00108-4

journal_volume

196

pub_type

杂志文章

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