Abstract:
:Activity in the hippocampus is modulated by novelty detection, and by the processing of conjunctions between two stimuli. We investigated whether the hippocampus is activated by discrimination of stimulus-stimulus relationships in novel versus familiar pairs of visual stimuli in 15 healthy subjects using functional magnetic resonance imaging. Subjects were asked to recognize the previously rewarded stimulus in each case. We found significantly greater activation of the right hippocampus when discriminating previously seen compared with novel pairs of visual stimuli. This activation was evident in individual subjects and was not related to stimulus novelty, reward contingency, or task instruction. Right hippocampal activation during discrimination of previously seen pairs of objects was correlated with activity in the anteromedial thalamus, cingulate cortex, and contralateral hippocampus.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Ongür D,Zalesak M,Weiss AP,Ditman T,Titone D,Heckers Sdoi
10.1016/j.pscychresns.2005.05.006subject
Has Abstractpub_date
2005-08-30 00:00:00pages
191-8issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(05)00071-5journal_volume
139pub_type
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