Hippocampal activation during processing of previously seen visual stimulus pairs.


:Activity in the hippocampus is modulated by novelty detection, and by the processing of conjunctions between two stimuli. We investigated whether the hippocampus is activated by discrimination of stimulus-stimulus relationships in novel versus familiar pairs of visual stimuli in 15 healthy subjects using functional magnetic resonance imaging. Subjects were asked to recognize the previously rewarded stimulus in each case. We found significantly greater activation of the right hippocampus when discriminating previously seen compared with novel pairs of visual stimuli. This activation was evident in individual subjects and was not related to stimulus novelty, reward contingency, or task instruction. Right hippocampal activation during discrimination of previously seen pairs of objects was correlated with activity in the anteromedial thalamus, cingulate cortex, and contralateral hippocampus.


Psychiatry Res


Psychiatry research


Ongür D,Zalesak M,Weiss AP,Ditman T,Titone D,Heckers S




Has Abstract


2005-08-30 00:00:00














  • The mRNA expression of DRD2, PI3KCB, and AKT1 in the blood of acute schizophrenia patients.

    abstract::The phosphoinositide 3 kinase - protein kinase B (PI3K-Akt) signaling pathway plays an important role in the dopamine D2 receptor (DRD2) pathway and in the pathophysiology of schizophrenia. This study measured the mRNA levels of DRD2, PI3KCB, and AKT1 in peripheral blood samples from 24 acute schizophrenia patients an...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Liu L,Luo Y,Zhang G,Jin C,Zhou Z,Cheng Z,Yuan G

    更新日期:2016-09-30 00:00:00

  • Sensitization and tolerance to apomorphine in men: yawning, growth hormone, nausea, and hyperthermia.

    abstract::This study investigated whether the indices of dopaminergic function, yawning and growth hormone release induced by apomorphine, as well as the drug-induced nausea and hyperthermia, show sensitization or tolerance to repeated injections. Five normal volunteers received 12 injections of apomorphine hydrochloride (0.75 ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Szechtman H,Cleghorn JM,Brown GM,Kaplan RD,Franco S,Rosenthal K

    更新日期:1988-03-01 00:00:00

  • Elevated serum lactate associated with panic attacks induced by hyperventilation.

    abstract::Several lines of evidence suggest that lactate metabolism may be altered in panic disorder. We recently reported exaggerated increases in serum lactate in panic patients following hyperventilation during glucose infusion. In the current study, lactate metabolism was stimulated by hyperventilation following glucose ing...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Maddock RJ,Carter CS,Gietzen DW

    更新日期:1991-09-01 00:00:00

  • What your eyes tell me: Theory of mind in bipolar disorder.

    abstract::The aim of this study was to assess social- perceptual Theory of Mind in bipolar disorder (BD). 112 euthymic participants with BD I or BD II (65 with BD I and 47 with BD II) were compared to a group of 112 persons with no psychiatric diagnosis and 43 with unipolar depression (UD). They completed the task of the "Readi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Espinós U,Fernández-Abascal EG,Ovejero M

    更新日期:2018-04-01 00:00:00

  • Psychosocial predictors of psychological, neurochemical and immunological symptoms of acute stress among breast cancer patients.

    abstract::The purpose of this study was to determine the impact of locus of control, social support and their interaction on acute stress indicators as a consequence of the communication of the results of a breast biopsy. Immunological and psychological indicators were evaluated in 50 patients with breast tenderness. We found l...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Gerits P,De Brabander B

    更新日期:1999-01-18 00:00:00

  • Investigation of a possible diencephalic pathology in schizophrenia.

    abstract::Absence of the adhesio interthalamica (AI) in schizophrenic first episode patients is suggestive for another marker of early developmental neuropathologic changes. Moreover, findings suggest that schizophrenic patients without AI are characterised by more severe negative symptoms. The study aims to investigate the pre...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Meisenzahl EM,Frodl T,Zetzsche T,Leinsinger G,Maag K,Hegerl U,Hahn K,Möller HJ

    更新日期:2002-10-01 00:00:00

  • Factors associated with completing evidence-based psychotherapy for PTSD among veterans in a national healthcare system.

    abstract::Little is known about predictors of initiation and completion of evidence-based psychotherapy (EBP) for posttraumatic stress disorder (PTSD), with most data coming from small cohort studies and post-hoc analyses of clinical trials. We examined patient and treatment factors associated with initiation and completion of ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Maguen S,Li Y,Madden E,Seal KH,Neylan TC,Patterson OV,DuVall SL,Lujan C,Shiner B

    更新日期:2019-04-01 00:00:00

  • Early childhood infections and risk of schizophrenia.

    abstract::The association between early childhood infections and the risk of schizophrenia is not clear, and this study aimed to investigate the association between childhood infections and the risk of schizophrenia in a population-based Australia male cohort. A population-based cohort of males born between 1980 and 1984 in Wes...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Liang W,Chikritzhs T

    更新日期:2012-12-30 00:00:00

  • Neurobiological effects of lumbar puncture stress in psychiatric patients and healthy volunteers.

    abstract::Several existing laboratory-based stress paradigms have significant shortcomings for assessing neurobiological correlates of stress in healthy volunteers and severely ill psychiatric patients. We have examined neuroendocrine effects of stress associated with the lumbar puncture (LP) procedure in drug-free depressed an...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Breier A,Wolkowitz OM,Doran AR,Bellar S,Pickar D

    更新日期:1988-08-01 00:00:00

  • Altered relationships between age and functional brain activation in adolescents at clinical high risk for psychosis.

    abstract::Schizophrenia is considered a neurodevelopmental disorder, but whether the adolescent period, proximal to onset, is associated with aberrant development in individuals at clinical high risk (CHR) for psychosis is incompletely understood. While abnormal gray and white matter development has been observed, alterations i...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Karlsgodt KH,van Erp TG,Bearden CE,Cannon TD

    更新日期:2014-01-30 00:00:00

  • Decreased cardiac MIBG uptake, its correlation with clinical symptoms in dementia with Lewy bodies.

    abstract::Recent studies have demonstrated the usefulness of 123I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy for the diagnosis of dementia with Lewy bodies (DLB). In this study, we investigated the relationship between decreased cardiac MIBG uptake and clinical symptoms in DLB. Thirty-six patients with probable DLB...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kobayashi S,Tateno M,Morii H,Utsumi K,Saito T

    更新日期:2009-10-30 00:00:00

  • The effects of aerobic exercise on cognition in schizophrenia: A 3-month follow-up study.

    abstract::Aerobic exercise (AE) has been shown to improve cognition in patients with schizophrenia. However, it remains unclear whether these exercise-induced cognitive benefits persist beyond the training period. Accordingly, the present study sought to examine the immediate and maintenance effects of AE on a wide range of cog...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Su CY,Wang PW,Lin YJ,Tang TC,Liu MF,Chen MD

    更新日期:2016-10-30 00:00:00

  • Relationship between obsessive-compulsive symptoms and smoking habits amongst schizophrenic patients.

    abstract::The rate of smoking is especially high among patients with schizophrenia (SCH) and schizoaffective disorder (SCHAFF). Patients with obsessive-compulsive disorder (OCD) smoke less than the general population. OCD symptoms are more frequent among patients with SCH or SCHAFF than in the general population, but it is stil...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Dome P,Teleki Z,Gonda X,Gaszner G,Mandl P,Rihmer Z

    更新日期:2006-11-15 00:00:00

  • Structural validation of The Patient Health Questionnaire-9 (PHQ-9) among Filipina and Indonesian female migrant domestic workers in Macao: STRUCTURAL VALIDATION OF PHQ-9.

    abstract::Within diverse global populations, validated tools are needed to assess common mental disorders. The Patient Health Questionnaire-9 (PHQ-9) is one of the most commonly used depression screeners. However, the PHQ-9 has not been structurally validated among female migrant domestic workers (MDWs). Female MDWs constitute ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Hall BJ,Patel A,Lao L,Liem A,Mayawati EH,Tjipto S

    更新日期:2021-01-01 00:00:00

  • Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder.

    abstract::The cognitive significance of P300 abnormalities in schizophrenia and obsessive-compulsive disorder (OCD) was investigated. P300 was measured by an auditory oddball paradigm, in which a series of standard tones (1000 Hz) and target tones (1500 Hz) were presented. The subject's task was to count the number of the prese...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kim MS,Kang SS,Youn T,Kang DH,Kim JJ,Kwon JS

    更新日期:2003-06-30 00:00:00

  • Relationship between mental states in depression: the assimilation model perspective.

    abstract::Metacognitive theories describe relationships between mental-affective self-states, including the capacity of one self-state to reflect upon another self-state. The assimilation model is a metacognitive approach that understands self-states as made of traces of experiences at different levels of integration. Psycholog...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Osatuke K,Stiles WB,Barkham M,Hardy GE,Shapiro DA

    更新日期:2011-11-30 00:00:00

  • Coping and quality of life of soldiers' wives following military operation.

    abstract::The aim of this study was to evaluate the relationships between coping strategies and four dimensions of quality of life (QOL) (physical, psychological, social relations and environment) among military wives. We examined these links six months after the military operation termed Protective Edge. Data were collected fr...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Braun-Lewensohn O,Bar R

    更新日期:2017-08-01 00:00:00

  • Post-traumatic psychological changes among survivors of the Lushan earthquake living in the most affected areas.

    abstract::The primary objective of our study was to investigate both the negative and positive psychological changes following the Lushan earthquake, and to explore the factors associated with psychological changes. Multi-stage random sampling was used to select respondents from Lushan County, Sichuan Province, China. A simplif...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


    authors: Tang B,Kang P,Liu X,Liu Y,Liu Z,Wang B,Lv Y,Zhang L

    更新日期:2014-12-15 00:00:00

  • Over the mainstream: diagnostic requirements for biological psychiatric research.

    abstract::Progress in biological psychiatry is contingent on progress in neurobiology and on research into proper characterisation and assessment of abnormal behavior. Advances in neurobiology are rapid and steady; diagnostic research does not keep pace. On the contrary, the diagnostic approach seems solidified, as today's basi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: van Praag HM

    更新日期:1997-10-10 00:00:00

  • Cognitive empathy contributes to poor social functioning in schizophrenia: Evidence from a new self-report measure of cognitive and affective empathy.

    abstract::Cognitive empathy impairments have been linked to poor social functioning in schizophrenia. However, prior studies primarily used self-reported empathy measures developed decades ago that are not well-aligned with contemporary models of empathy. We evaluated empathy and its relationship to social functioning in schizo...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Michaels TM,Horan WP,Ginger EJ,Martinovich Z,Pinkham AE,Smith MJ

    更新日期:2014-09-04 00:00:00

  • Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation.

    abstract::Proton magnetic resonance spectroscopy ((1)H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use (1)H MRS to assess ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Urrila AS,Hakkarainen A,Heikkinen S,Huhdankoski O,Kuusi T,Stenberg D,Häkkinen AM,Porkka-Heiskanen T,Lundbom N

    更新日期:2006-06-30 00:00:00

  • Differential diagnosis of schizophrenia and schizoaffective disorder from normal subjects using virtual reality.

    abstract::Dysfunction of allocentric and egocentric memories is one of the core features of psychiatric disorders. There are a few navigational studies on these memories in schizophrenia and bipolar disorders, but studies in schizoaffective disorder are lacking. Here, we aim to explore allocentric and egocentric navigation defi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kargar M,Askari S,Khoshaman A,Mohammadi A

    更新日期:2019-03-01 00:00:00

  • A new treatment for children with chronic tic disorders - Resource activation.

    abstract::The aim of this pilot study is to evaluate the efficacy of a resource activation (RA) program as an alternative intervention for children and adolescents with tic disorders. RA interventions focus on the strengths and abilities of the patients. This is expected to improve the patients' perceptions regarding their own ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Viefhaus P,Feldhausen M,Görtz-Dorten A,Volk H,Döpfner M,Woitecki K

    更新日期:2019-03-01 00:00:00

  • Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.

    abstract::This study aimed to evaluate the effectiveness of electroconvulsive therapy (ECT) among patients with treatment resistant schizophrenia (TRS). Records of patients who had received ECT were reviewed to identify patients with TRS who were administered ECT in combination with clozapine. Socio-demographic, clinical data a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Grover S,Chakrabarti S,Hazari N,Avasthi A

    更新日期:2017-03-01 00:00:00

  • Time perception networks and cognition in schizophrenia: a review and a proposal.

    abstract::Timing is an essential function for the survival of many living organisms. Despite its significance, it is relatively under-researched, particularly in schizophrenia. We examined neurophysiological, neuropathological, imaging and genetic studies of both healthy subjects and subjects suffering from schizophrenia in rel...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Gómez J,Jesús Marín-Méndez J,Molero P,Atakan Z,Ortuño F

    更新日期:2014-12-30 00:00:00

  • Sleep disturbances and suicidal ideation in a sample of treatment-seeking Canadian Forces members and veterans.

    abstract::This study examines the association between suicidal ideation and sleep disturbances in a sample of treatment-seeking Canadian Forces members and veterans, after controlling for probable posttraumatic stress disorder (PTSD), major depressive disorder (MDD), generalised anxiety disorder (GAD), and alcohol use disorder ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Don Richardson J,Cyr KS,Nelson C,Elhai JD,Sareen J

    更新日期:2014-08-15 00:00:00

  • Parental style and Cloninger's model in psychosis.

    abstract::Parental style and Cloninger's dimensions are associated with psychosis, but it is still unclear whether temperament, character and parenting variables are linked to specific psychotic symptoms. This study extends previous research exploring these issues. 78 patients with psychosis and 156 control subjects were recrui...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Mansueto G,Palmieri S,Faravelli C

    更新日期:2018-11-01 00:00:00

  • Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients.

    abstract::Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrela...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lee HY,Kim YK

    更新日期:2010-01-30 00:00:00

  • Using patient-reported outcome measures for program evaluation: Design and findings on intention-to-treat outcomes from the Veterans Outcome Assessment survey.

    abstract::The Veterans Outcomes Assessment (VOA) program surveys Veteran Health Administration (VHA) patients when they begin mental health treatment and at follow-up at three months to obtain patient-reported outcomes measures (PROM). It complements VA's evolving program in measurement-based care by providing additional data t...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Katz IR,Resnick SG,Kasprow WJ,Boden MT,Cherkasova E,Fielstein EM,Trafton JA,Hoff RA

    更新日期:2020-09-01 00:00:00

  • Facial emotion recognition in Chinese with schizophrenia at early and chronic stages of illness.

    abstract::Deficits in facial emotion recognition have been recognised in Chinese patients diagnosed with schizophrenia. This study examined the relationship between chronicity of illness and performance of facial emotion recognition in Chinese with schizophrenia. There were altogether four groups of subjects matched for age and...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Leung JS,Lee TM,Lee CC

    更新日期:2011-12-30 00:00:00