Abstract：
:Normal brain activity is associated with task-related pH changes. Although central nervous system syndromes associated with significant acidosis and alkalosis are well understood, the effects of less dramatic and chronic changes in brain pH are uncertain. One environmental factor known to alter brain pH is the extreme, acute change in altitude encountered by mountaineers. However, the effect of long-term exposure to moderate altitude has not been studied. The aim of this two-site study was to measure brain intracellular pH and phosphate-bearing metabolite levels at two altitudes in healthy volunteers, using phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS). Increased brain pH and reduced inorganic phosphate (Pi) levels were found in healthy subjects who were long-term residents of Salt Lake City, UT (4720ft/1438m), compared with residents of Belmont, MA (20ft/6m). Brain intracellular pH at the altitude of 4720ft was more alkaline than that observed near sea level. In addition, the ratio of inorganic phosphate to total phosphate signal also shifted toward lower values in the Salt Lake City region compared with the Belmont area. These results suggest that long-term residence at moderate altitude is associated with brain chemical changes.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Shi XF,Carlson PJ,Kim TS,Sung YH,Hellem TL,Fiedler KK,Kim SE,Glaeser B,Wang K,Zuo CS,Jeong EK,Renshaw PF,Kondo DGdoi
10.1016/j.pscychresns.2014.04.002subject
Has Abstractpub_date
2014-06-30 00:00:00pages
149-56issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(14)00085-7journal_volume
222pub_type
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