Abstract：
:Recent studies have reported that patients with unipolar major depression may show a lower whole brain cerebral blood flow (CBF) and reduced regional CBF in frontal, temporal, and parietal lobes. The present study used single photon emission computed tomography (SPECT) with the CBF marker Tc-99m-hexamethylpropyleneamineoxine (HMPAO) to measure the cortical CBF of six individual regions of interest (ROIs), total ROI, and left or right hemispheric total ROI in 43 unipolar depressed subjects and 12 normal control subjects. There were no significant differences in the distribution of Tc-99m-HMPAO uptake into total ROI, right or left global ROI, prefrontal, motor frontal, parietal, temporal, visual cortex, or associative visual cortex between patients with melancholic depression, simple major depression, or minor depression and healthy control subjects. There were also no significant differences in the right-left distribution of uptake between the patients and the control subjects. Hypoperfusion was observed in motor frontal and parietal cortex of patients who had been taking benzodiazepines during the study period. It is concluded that cortical CBF, as assessed with Tc-99m-HMPAO SPECT, is relatively intact in the present sample of patients with severe depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Maes M,Dierckx R,Meltzer HY,Ingels M,Schotte C,Vandewoude M,Calabrese J,Cosyns Pdoi
10.1016/0925-4927(93)90012-7subject
Has Abstractpub_date
1993-06-01 00:00:00pages
77-88issue
2eissn
0165-1781issn
1872-7123pii
S0165-1781(05)80002-2journal_volume
50pub_type
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