Abstract:
:We investigated the serotonin transporter gene (5-HTTLPR) in the functioning of euthymic patients with mood disorders (n=285) and healthy controls (n=94). The 5-HTTLPR genotype showed marginal associations with working, familial and social adjustment, with marked differences between controls and patients. Because of the exploratory nature of our analyses, all results should be viewed with caution. However, we observed how the s/s variant, commonly associated with detrimental effects, could be beneficial in specific areas of social adjustment.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Serretti A,Mandelli L,Lorenzi C,Smeraldi Edoi
10.1016/j.psychres.2005.01.006subject
Has Abstractpub_date
2005-04-15 00:00:00pages
191-4issue
2eissn
0165-1781issn
1872-7123pii
S0165-1781(05)00026-0journal_volume
134pub_type
杂志文章abstract::This study examined season-of-assessment differences in parent and child reports of depressive problems on well-validated instruments in 2009 U.S. children and adolescents, aged 6 to 18 years, from a nationally representative population survey. A parent completed the Child Behavior Checklist (CBCL) for each participan...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2008.07.011
更新日期:2009-12-30 00:00:00
abstract::Serum prolactin levels were monitored for 2 hours after injection of chlorpromazine (CPZ) 50 mg intramuscularly (i.m.) in 6 male normal controls and 14 newly admitted male chronic schizophrenics. The increase in serum prolactin levels in the male normal controls was not significantly different from that in patients. S...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(81)90065-2
更新日期:1981-08-01 00:00:00
abstract::We have previously reported decreased heart rate variability upon standing in panic disorder patients compared with controls. In this study, we extend our report to include patients with major depression (n = 19). Compared to normal controls (n = 20) and panic disorder patients (n = 30), there was no significant diffe...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(91)90104-w
更新日期:1991-04-01 00:00:00
abstract::The seven-factor model of personality developed by Cloninger and colleagues describes personality as a function of developmental aspects of character superimposed on heritable dimensions of temperament. The objective of this study was to determine whether this model could be applied to early childhood. We tested a pre...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00008-2
更新日期:2002-04-15 00:00:00
abstract::There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). The present study was carried out in order to examine the effects of noradrenaline (10(-5), 10(-6) and 10(-7) M), clonidine (10(-5), 10(-6) and 10(-7) ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(00)00216-x
更新日期:2000-11-20 00:00:00
abstract::The purpose of this study was to examine social context processing in persons with schizophrenia. A secondary goal was to examine the ecological validity of these measures (i.e. how they relate to social behavior in the treatment setting). The performance of 35 persons with DSM-IV diagnosed schizophrenia and/or schizo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00004-5
更新日期:2002-03-15 00:00:00
abstract::We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.07.008
更新日期:2011-12-30 00:00:00
abstract::Childhood trauma exposure has been associated with a clinically relevant mixed phenotype of psychopathology composed of depressive, anxiety, and psychosis symptoms, across healthy and clinical samples. Altered stress-reactivity after exposure to childhood trauma may be a plausible underlying mechanism explaining this ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.12.012
更新日期:2018-02-01 00:00:00
abstract::Precise rules for locating the anatomical boundaries of the dorsolateral prefrontal cortex (DLPFC) or its subdivisions, i.e., superior, inferior and middle frontal gyri (SFG, IFG and MFG) on magnetic resonance images (MRI), have not been defined. The present study describes the inter-rater reliability of manual segmen...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2006.05.006
更新日期:2006-12-01 00:00:00
abstract::The purpose of this study was to examine patients' response profiles to the Medication Adherence Rating Scale (MARS) and to evaluate the potential of response styles as predictors of the future course of psychotic disorders in terms of rehospitalisation and maintenance of medication. A total of 371 psychiatric in-pati...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.03.033
更新日期:2012-12-30 00:00:00
abstract::The most significant contributor to premature mortality in patients with bipolar disorder is preventable cardiovascular diseases. This study investigated if the Physical Activity Vital Sign (PAVS) assessment (two questions which clarify if a person meets the recommended 150min of physical activity per week) can identi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.06.060
更新日期:2016-12-30 00:00:00
abstract::Neuroimaging in anorexia nervosa has revealed morphological and functional alterations, most of which are currently interpreted as consequences of the anorectic state that are reversible, at least partially, after weight gain. Enlargement of CSF spaces, mainly of cortical sulci, is evident on CT and MRI. This reversib...
journal_title:Psychiatry research
pub_type: 杂志文章,评审
doi:10.1016/0165-1781(96)02990-3
更新日期:1996-04-16 00:00:00
abstract::Children's mental health problems substantially impact their functioning. For clinically treated children and adolescents, we explored the impact of mental health treatment on functioning and identified predictors of functional improvement. Outpatient clinical data from a regional publicly funded specialist outpatient...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.01.093
更新日期:2019-03-01 00:00:00
abstract::The processing of social stimuli generated by one's own voluntary behavior is an element of social adaptation. It is known that self-generated stimuli induce attenuated sensory experiences compared with externally generated stimuli. The present study aimed to examine this self-specific attenuation effect on early stim...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.12.037
更新日期:2019-01-01 00:00:00
abstract::In people with schizophrenia several factors are associated with poor quality of life (QoL), namely, lifestyle-related factors and psychological factors. However, there has been little research on the impact of these factors on QoL. Therefore, the relation between lifestyle-related factors, psychological factors, and ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.06.022
更新日期:2018-09-01 00:00:00
abstract::The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment-resistant gro...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.08.037
更新日期:2016-11-30 00:00:00
abstract::We wished to determine whether decreases in prefrontal glutamate concentrations occur in offspring of parents with bipolar disorder with and at high risk for mania. Sixty children and adolescents, 9-18 years old, of parents with bipolar I or II disorder (20 offspring with established history of mania, "BD", 20 offspri...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2010.01.003
更新日期:2010-05-30 00:00:00
abstract::Psychotic symptoms have been related to other coronavirus infections. We conducted a single-centre retrospective and observational study to describe new-onset psychotic episodes in COVID-19 patients. Ten patients infected by the novel coronavirus with psychotic symptoms and no previous history of psychosis were identi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113254
更新日期:2020-09-01 00:00:00
abstract::Recent evidence demonstrates that hippocampal hyperactivity helps mediate psychosis. Using resting state functional magnetic resonance imaging (rsfMRI), we examined hippocampal connectivity alterations in individuals with psychosis (PS) versus healthy controls (HC). Because of its putative greater involvement in psych...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2015.06.004
更新日期:2015-08-30 00:00:00
abstract::This study examines the relationship between psychiatrists׳ fear of death and negative emotions toward patients with borderline personality disorder (BPD). A survey (N=120) demonstrated that fear of death is associated with stronger negative attitudes toward BPD patients, after controlling for attitudes toward suicide...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.06.010
更新日期:2015-08-30 00:00:00
abstract::The purpose of this study was to investigate the influence of clozapine on plasma serotonin, platelet serotonin and monoamine oxidase (MAO) levels in schizophrenic patients and to compare their results with those of unmedicated healthy controls. Groups of 20 outpatients with schizophrenia and 20 healthy controls match...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/j.psychres.2005.12.009
更新日期:2007-01-15 00:00:00
abstract::Schizophrenia (n=68) and control (n=62) participants matched on cigarette smoking history were assessed on executive function, decision-making and impulsivity tasks. In controls, executive function and decision-making correlated positively with each other and negatively with impulsivity. There were no inter-task corre...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.08.022
更新日期:2013-01-30 00:00:00
abstract::This study had three aims: to compare a schizophrenia sample (n = 50) with a substance abuse (n = 25) and normal sample (n = 81) on affect recognition; to compare differences in their performance between positive and negative affect recognition; and to introduce a new videotape method of stimulus presentation. Subject...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(97)00111-x
更新日期:1997-11-14 00:00:00
abstract::In this paper we studied the appropriateness of developing an adaptive version of the Center of Epidemiological Studies-Depression (CES-D, Radloff, 1977) scale. Computerized Adaptive Testing (CAT) involves the computerized administration of a test in which each item is dynamically selected from a pool of items until a...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.12.001
更新日期:2011-06-30 00:00:00
abstract::Behavioral changes in 44 subjects with well-characterized mild senile dementia of the Alzheimer's type (SDAT) and 16 subjects with only questionable SDAT were compared to a control group of 58 subjects. Answers to both open-ended questions and personality items from the Blessed Dementia Scale were examined. Seventeen ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(87)90062-x
更新日期:1987-05-01 00:00:00
abstract:PURPOSE:Since conduct problems (CP) vary distinctly across youths, better subtyping CP may be an important vehicle to study specific risk factors associated to differential patterns of CP. In a sample of 63,196 adolescents, we employed a two-step method to the identify such CP patterns and to help classify youths based...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113640
更新日期:2020-12-11 00:00:00
abstract::MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop fa...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.01.006
更新日期:2016-02-28 00:00:00
abstract::Male research subjects were administered placebo and three doses of d-amphetamine (5, 10, and 20 mg/70 kg of body weight) under double-blind conditions in a laboratory situation that provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by the presentati...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(87)90030-8
更新日期:1987-07-01 00:00:00
abstract::Time perception (TP) impairment in schizophrenia has been originally described by clinicians and afterwards addressed in laboratory. Previous studies generally observed that schizophrenia patients overestimate time and that their timing sensitivity is impaired. However, because of the disease cognitive impairments, no...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.06.008
更新日期:2012-12-30 00:00:00
abstract::Alexithymia is common in patients with a substance use disorder (SUD) and is possibly a negative prognostic factor in their treatment. The aim of this study was twofold. First, we explored whether SUD patients with posttraumatic stress disorder (PTSD) are more alexithymic than SUD patients without PTSD. Next, we explo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.112634
更新日期:2019-12-01 00:00:00