Abstract：
:Behavioral changes in 44 subjects with well-characterized mild senile dementia of the Alzheimer's type (SDAT) and 16 subjects with only questionable SDAT were compared to a control group of 58 subjects. Answers to both open-ended questions and personality items from the Blessed Dementia Scale were examined. Seventeen items were classified into seven categories by factor analysis and then further categorized into four clinically useful groups: passive, agitated, self-centered, and suspicious. Over 75% of subjects with mild SDAT had behavioral changes compared to 10% of controls. Passive symptoms were the most common, occurring in two-thirds of mild SDAT subjects. Agitated and self-centered symptoms were also common, occurring half as frequently as passive symptoms. Passive symptoms occurred alone in 25% of those with mild SDAT, whereas passive symptoms, together with agitated and/or self-centered symptoms, were present in 11-16% of subjects with mild SDAT. Agitated or self-centered symptoms rarely occurred alone. Characterizing the behavioral symptoms of SDAT is important for their clinical implications and for an approach to understanding brain-behavioral relationships.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Rubin EH,Morris JC,Storandt M,Berg Ldoi
10.1016/0165-1781(87)90062-xsubject
Has Abstractpub_date
1987-05-01 00:00:00pages
55-62issue
1eissn
0165-1781issn
1872-7123pii
0165-1781(87)90062-Xjournal_volume
21pub_type
杂志文章abstract：:Blood from chronic schizophrenic patients in two hospitals (A and B) and from institutional and noninstitutional controls was analyzed for platelet monoamine oxidase (MAO) activity toward three different substrates (tryptamine, phenylethylamine, and p-tyramine) and for plasma levels of conjugated and unconjugated phen...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(82)90042-7
更新日期：1982-02-01 00:00:00
abstract：:Positron emission tomography was used to study the effects of experimentally controlled mood states on cerebral blood flow (CBF), measured with the quantitative equilibrium infusion method and 15O-labeled water. Twenty-seven brain regions in each hemisphere were assessed in 16 normal subjects. CBF and heart rate were ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(95)02678-q
更新日期：1995-11-10 00:00:00
abstract：:This study assessed the subjective and cardiovascular effects of relevant doses of cocaine administration during steady-state treatment of the combination of amantadine and baclofen compared to placebo. Participants included 8 healthy, male, cocaine-dependent, non-treatment-seeking individuals (age=36.6+/-5.9; 75% Afr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.03.012
更新日期：2007-08-30 00:00:00
abstract：:Considerable disagreement exists about the neuroanatomical basis of conceptual-semantic impairments observed in a subgroup of patients with Alzheimer's disease (AD) at mild to moderate stages of the disease. Several studies of groups of patients have shown correlations between focal hypometabolism or hypoperfusion in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2004.07.006
更新日期：2004-12-15 00:00:00
abstract：:Dopamine agonists impair and antagonists normalize prepulse inhibition (PPI) of startle and gating of the P50 event-related potential (ERP), but the within-subject effect of treatment on impaired gating in schizophrenia has not been studied. We report the first results of a longitudinal study using PPI of ERPs as a me...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(98)00053-5
更新日期：1999-02-22 00:00:00
abstract：:We developed a semiautomatic method termed "cortical circumferential profiling" for objective analysis of cerebral cortex function in emission tomographic neuroimaging studies. This method treats cortex as a continuous ring near the outer brain edge. A computer algorithm samples the cortex at 60 contiguous, equiangula...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(91)90008-e
更新日期：1991-11-01 00:00:00
abstract：:Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they pr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.11.001
更新日期：2010-09-30 00:00:00
abstract：:Our aim is to assess cross-national variations in prevalence of clinically relevant depression and to examine the relationships of social and health factors with depression in five diverse populations of older adults, from Canada, Brazil, Colombia and Albania. We used the data from the International Mobility in Aging ...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2016.04.096
更新日期：2016-07-30 00:00:00
abstract：:Hypersensitivity to sensory stimulation is a prominent characteristic of both schizophrenia and mania. Neurophysiological recordings suggest a common deficit in a central neuronal sensory gating mechanism which regulates sensitivity to repeated auditory stimuli. Dopamine and norepinephrine are hypothesized to have maj...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90099-q
更新日期：1990-03-01 00:00:00
abstract：:Impairments on neuropsychological and eye movement tasks have been demonstrated in schizophrenic patients and also reported in their unaffected relatives. However, it is not clear to what extent these phenotypes overlap. This study examined the relationship between specific eye movement and neuropsychological measures...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.05.008
更新日期：2009-08-15 00:00:00
abstract：:Methamphetamine (METH) users showed structural and chemical abnormalities on magnetic resonance (MRI) studies, particularly in the frontal and basal ganglia brain regions. Diffusion tensor imaging (DTI) may provide further insights regarding the microstructural changes in METH users. We investigated diffusion tensor m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.03.011
更新日期：2009-10-30 00:00:00
abstract：:The interplay between Callous Unemotional Traits (CU) and Moral Disengagement (MD) was examined in a sample of 90 adolescents with Disruptive Behavior Disorders. Using a person-centered approach, three CU and MD configurations were identified, attesting the strong relationship between these two moral dimensions. Howev...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.043
更新日期：2017-12-01 00:00:00
abstract：:The astonishing 20 fold growth of the yearly published psychiatric research literature over the past four decades has been paralleled and facilitated by the internet application of electronic publishing. This personal history highlights the decade by decade 1978-2018 augmentation and erosion of this interelationship f...
journal_title：Psychiatry research
pub_type： 历史文章,杂志文章
doi：10.1016/j.psychres.2019.01.071
更新日期：2019-07-01 00:00:00
abstract：:Reduced motor activity is associated with depression. Lewinsohn's cognitive behavioural model of depression assumes a lack of positive experience due to a reduced level of activity as a key aspect of depression. The acute relationship between motor activity and mood as well as between motor activity and incentive driv...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.09.009
更新日期：2017-01-01 00:00:00
abstract：:Reliability and validity of direct visual analogue scale (VAS) ratings of improvement were assessed in 162 patients with Seasonal Affective Disorder, Winter Depression type (W-SAD), after light treatment for 6 consecutive days. The patients were rated with the Montgomery-Asberg Depression Rating Scale (MADRS) and a sc...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(98)00119-x
更新日期：1998-12-14 00:00:00
abstract：:Modest alcohol and aggressive trait effects on laboratory-induced aggression among men have been reported with some consistency in the literature. Relationships between aggressive personality traits and laboratory-induced aggression appear to become less consistent under the influence of alcohol. Several research team...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2005.10.015
更新日期：2006-06-15 00:00:00
abstract：:Neurological soft signs and neurocognitive impairments are commonly observed in first episode psychosis but the correlation of these factors remains controversial. Here, we evaluated 30 patients with remitted first episode psychosis and 30 healthy controls for the presence and severity of neurological soft signs (usin...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.07.044
更新日期：2014-12-15 00:00:00
abstract：:This study aimed to: (i) determine the prevalence, socio-demographic and clinical correlates of internalized stigma and (ii) explore the association between internalized stigma and quality of life, general functioning, hope and self-esteem, among a multi-ethnic Asian population of patients with mental disorders. This ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.10.041
更新日期：2016-12-30 00:00:00
abstract：:Serotonergic abnormalities have been regularly reported in the brains of suicide victims. Because of evidence that pineal function is altered in depressed subjects and that serotonin-releasing axons may innervate the pineal, we assayed tritiated serotonin binding in a series of control and suicide pineals. High affini...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90131-n
更新日期：1990-04-01 00:00:00
abstract：:The 2-deoxyglucose (2-DG) method was used to study regional metabolic changes in rats following chronic d-amphetamine treatment without subsequent challenges. Four groups of rats were pretreated (intraperitoneal administration) with d-amphetamine (0, 1, 5, or 10 mg/kg) once per day for 14 days. After a 7-day abstinenc...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02496-j
更新日期：1995-06-29 00:00:00
abstract：:Several studies have demonstrated that patients with schizophrenia are impaired in recognizing emotions from facial expressions and in appreciating other people's mental states--the latter commonly referred to as 'theory of mind.' The question as to how social cognitive skills relate to patients' actual social behavio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.10.007
更新日期：2005-02-28 00:00:00
abstract：:Since the magnitude of the first-night effect has been shown to be a function of medical conditions and of settings in which polysomnographies are performed, it is essential to evaluate the habituation phenomenon in each case in order to determine the optimal recording methodology. A first-night effect was evidenced i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(03)00185-9
更新日期：2003-09-30 00:00:00
abstract：:One of the central problems in posttraumatic stress disorder (PTSD) is the inability to suppress fear even under safe conditions. The neural underpinnings of fear are clinically relevant but poorly understood. This study assessed fear potentiation and fear inhibition using fear-potentiated startle in a conditional dis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.12.014
更新日期：2009-05-15 00:00:00
abstract：:Co-existence of Asperger syndrome (AS) and non-verbal learning disability (NLD) has been proposed based on the observation that people with AS tend to have significantly higher verbal than performance IQ (VIQ > PIQ by ≥ 15 points), one of the core features of NLD. In the present study we examined neuropsychological an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.006
更新日期：2013-12-15 00:00:00
abstract：:Sparse evidence of a co-aggregation of the risk of schizophrenia and bipolar disorder provides support for a shared but nonspecific genetic etiology of bipolar disorder and schizophrenia. Temperaments are conceptualized as trait sub-syndromic conditions of major pathologies. This study set out to test the hypothesis o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.10.027
更新日期：2015-01-30 00:00:00
abstract：:It is well-established that the secretion of the opioid neuropeptide beta-endorphin is perturbed by the administration of various drugs of abuse. Several investigators have speculated that variations in beta-endorphin secretory regulation may precede the development of a substance use disorder, and thus be a component...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(96)02880-6
更新日期：1996-06-01 00:00:00
abstract：:One of the leading biosocial theories of borderline personality disorder (BPD) suggests that individuals with BPD have biologically based abnormalities in emotion regulation contributing to more intense and rapid responses to emotional stimuli, in particular, invalidation [Linehan, M.M., 1993. Cognitive-Behavioral Tre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.06.007
更新日期：2008-01-15 00:00:00
abstract：:This study reports on the naturalistic pharmacotherapy of 266 youths with bipolar disorder (BP), manic or hypomanic episode (158 males and 108 females, 13.8+/-2.8 years), first treated with monotherapy on valproic acid (VPA) (n=158, 59.4%), lithium (n=90, 33.8%) or atypical antipsychotics (n=18, 6.8%). Among the patie...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.01.022
更新日期：2010-05-15 00:00:00
abstract：:We report the psychopathological features in a large Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. Of the 23 living family members, 14 were evaluated using the Structured Clinical Interview for DSM-IV, the Yale-Brown Obsessive-Compulsive Scale, the Clinical Global Impression and th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.02.012
更新日期：2008-10-30 00:00:00
abstract：:We compared regional cerebral blood flow (rCBF) in 15 patients with DSM IIIR obsessive-compulsive disorder (OCD), 15 patients with DSM IIIR panic disorder and 15 healthy controls matched for age, sex and hand preference, using uptake of technetium-99m-D,L-hexamethyl-propylene amine oxime (99mTc HMPAO), on single photo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(96)03017-x
更新日期：1997-03-14 00:00:00
