Plasma levels of phenylacetic acid, m- and p-hydroxyphenylacetic acid, and platelet monoamine oxidase activity in schizophrenic and other patients.

Abstract:

:Blood from chronic schizophrenic patients in two hospitals (A and B) and from institutional and noninstitutional controls was analyzed for platelet monoamine oxidase (MAO) activity toward three different substrates (tryptamine, phenylethylamine, and p-tyramine) and for plasma levels of conjugated and unconjugated phenylacetic acid (PAA) and m- and p-hydroxyphenylacetic acids (mHPA and pHPA). Compared to the controls, schizophrenic patients were found to have significantly reduced MAO activity. Although significant differences were found between unconjugated PAA (reduced) in Hospital B, conjugated pHPA (increased) in Hospital A, and conjugated PAA (increased) in Hospitals A and B and noninstitutional controls, the most consistent significant finding was a reduced unconjugated mHPA in both groups of schizophrenic patients compared with both control groups.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Davis BA,Yu PH,Carlson K,O'Sullivan K,Boulton AA

doi

10.1016/0165-1781(82)90042-7

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

97-105

issue

1

eissn

0165-1781

issn

1872-7123

pii

0165-1781(82)90042-7

journal_volume

6

pub_type

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