Abstract：
:Ictal heart rate (HR) and postictal suppression in ictal EEG are believed to be predictive of the therapeutic efficacy of eletroconvulsive therapy (ECT) for depression. However, regarding ictal peak HR, previous studies investigated ictal HR on only one or two occasions during the course of ECT. We prospectively examined whether two physiological parameters, ictal peak HR and postictal suppression in ictal EEG, during every session, including those with abortive seizure, predicted ECT efficacy. Ictal peak HR and postictal suppression index were analyzed in 53 consecutive inpatients with depression using generalized estimating equations analysis, which corrects for the repeated nature of the observations. The peak HR and postictal suppression index were associated with therapeutic efficacy in remitters during sessions with adequate seizure. The physiological characteristics of the remitters included lower peak HR, lower stimulus energy, and higher postictal suppression index. However, these results could not be generalized, and are limited to non-atropine conditions and bilateral ECT.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Azuma H,Yamada A,Shinagawa Y,Nakano Y,Watanabe N,Akechi T,Furukawa TAdoi
10.1016/j.psychres.2010.05.007subject
Has Abstractpub_date
2011-02-28 00:00:00pages
462-4issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(10)00251-9journal_volume
185pub_type
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