Abstract：
:The aim of the present study was to investigate whether healthy first-degree relatives of schizophrenia patients show reduced sensitivity performance, higher intra-individual variability (IIV) in reaction time (RT), and a steeper decline in sensitivity over time in a sustained attention task. Healthy first-degree relatives of schizophrenia patients (n=23) and healthy control subjects (n=46) without a family history of schizophrenia performed a demanding version of the Rapid Visual Information Processing task (RVIP). RTs, hits, false alarms, and the sensitivity index A' were assessed. The relatives were significantly less sensitive, tended to have higher IIV in RT, but sustained the impaired level of sensitivity over time. Impaired performance on the RVIP is a possible endophenotype for schizophrenia. Higher IIV in RT, apparently caused by impaired context representations, might result in fluctuations in control and lead to more frequent attentional lapses.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hilti CC,Hilti LM,Heinemann D,Robbins T,Seifritz E,Cattapan-Ludewig Kdoi
10.1016/j.psychres.2009.12.012subject
Has Abstractpub_date
2010-05-15 00:00:00pages
60-4issue
1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(10)00003-Xjournal_volume
177pub_type
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