Impaired performance on the Rapid Visual Information Processing task (RVIP) could be an endophenotype of schizophrenia.

Abstract:

:The aim of the present study was to investigate whether healthy first-degree relatives of schizophrenia patients show reduced sensitivity performance, higher intra-individual variability (IIV) in reaction time (RT), and a steeper decline in sensitivity over time in a sustained attention task. Healthy first-degree relatives of schizophrenia patients (n=23) and healthy control subjects (n=46) without a family history of schizophrenia performed a demanding version of the Rapid Visual Information Processing task (RVIP). RTs, hits, false alarms, and the sensitivity index A' were assessed. The relatives were significantly less sensitive, tended to have higher IIV in RT, but sustained the impaired level of sensitivity over time. Impaired performance on the RVIP is a possible endophenotype for schizophrenia. Higher IIV in RT, apparently caused by impaired context representations, might result in fluctuations in control and lead to more frequent attentional lapses.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Hilti CC,Hilti LM,Heinemann D,Robbins T,Seifritz E,Cattapan-Ludewig K

doi

10.1016/j.psychres.2009.12.012

subject

Has Abstract

pub_date

2010-05-15 00:00:00

pages

60-4

issue

1-2

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(10)00003-X

journal_volume

177

pub_type

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