Abstract：
OBJECTIVE:We aimed to elucidate whether schizophrenia and type II diabetes mellitus may present with associated illness severity, in light of accumulating evidence to suggest both conditions have important shared inflammatory components with many shared inflammatory genetic factors. METHODS:We conducted a systematic review employing PRISMA criteria, searching EMBASE, Ovid MEDLINE, PsychInfo, Web of Science and Google Scholar to February 1st, 2017, for clinical studies assessing schizophrenia severity alongside dysglycaemia. A narrative synthesis was employed to discuss and compare findings between studies. RESULTS:Eleven observational studies were included in the analysis. Ten presented evidence in support of an association between schizophrenia severity and dysglycaemia. This association appeared particularly strong regarding negative symptomatology and impaired cognitive function, between which there may be some overlap. Studies examining positive symptomatology returned mixed results. CONCLUSION:Whilst study design varied amongst the included studies, the results suggest that further work examining the effect of hyperglycaemia on schizophrenia severity may be relevant, particularly longitudinal studies assessing negative symptomatology and cognitive function. To the authors' knowledge, this is the first systematic review conducted to address this question.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Perry BI,Salimkumar D,Green D,Meakin A,Gibson A,Mahajan D,Tahir T,Singh SPdoi
10.1016/j.psychres.2017.06.027subject
Has Abstractpub_date
2017-10-01 00:00:00pages
102-110eissn
0165-1781issn
1872-7123pii
S0165-1781(17)30673-Xjournal_volume
256pub_type
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