Abstract：
:Proton magnetic resonance spectroscopy ((1)H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use (1)H MRS to assess the effects of specific short-term physiological states on major metabolites. Eight healthy women underwent (1)H MRS at the beginning and end of a 40-h period of sleep deprivation. The ratios of N-acetyl-aspartate (NAA), total creatine (tCr), and choline-containing compounds (Cho) to water (H(2)O) were determined from the occipital cortex during both baseline and photic stimulation conditions. During sleep deprivation, NAA/H(2)O decreased by 7% and Cho/H(2)O by 12%. Photic stimulation had no effect on the measured metabolites in the alert state, but in the sleep-deprived state the level of Cho/H(2)O increased during neuronal activation. The results suggest that NAA/H(2)O and Cho/H(2)O may depend on the state of alertness.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Urrila AS,Hakkarainen A,Heikkinen S,Huhdankoski O,Kuusi T,Stenberg D,Häkkinen AM,Porkka-Heiskanen T,Lundbom Ndoi
10.1016/j.pscychresns.2006.01.010subject
Has Abstractpub_date
2006-06-30 00:00:00pages
41-6issue
1eissn
0165-1781issn
1872-7123pii
S0925-4927(06)00018-7journal_volume
147pub_type
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