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Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome--a proposal for a model of the onset of mania.

Abstract：

:Beta-Endorphin (0.3 or 0.6 nanomoles) was infused into the A10-ventral tegmental area (VTA) of male Wistar rats previously treated for 6 days with either morphine sulfate or lactose via subcutaneously implanted silastic pellets. Beta-Endorphin microinfusions occurred at 24 and 96 hours after pellets were removed. Profound changes in locomotor response to beta-endorphin were found, with morphine-pretreated rats showing a spontaneous switch from hyporesponsiveness to hyperresponsiveness over 72 hours, compared to lactose-pretreated controls. These findings may reflect on current biochemical theories regarding the "switch" process in bipolar affective disease. The data can be viewed within a heuristic model of receptor changes which may underlie the transition from depression to mania.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Schwartz JM,Ksir C,Koob GF,Bloom FE

doi

10.1016/0165-1781(92)90088-k

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

153-61

issue

2

eissn

0165-1781

issn

1872-7123

pii

0165-1781(92)90088-K

journal_volume

7

pub_type

杂志文章

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