Abstract:
:The aim of this paper is to extensively review the current literature available on N-acetylcysteine (NAC) treatment for cocaine dependence (clinical and experimental studies). We screened all articles published before February 2016 reporting on the use of NAC as a pharmacological intervention for cocaine dependence or discussed its potential as a therapeutic approach for cocaine dependence. We described our results qualitatively. 21 studies matched our search criteria: 6 clinical trials and 15 animal studies. Four clinical studies showed NAC's capacity to reduce craving, desire to use cocaine, cocaine-cue viewing-time and cocaine-related spending. Studies in animal models also support this reinstatement prevention application of NAC. NAC reverses the disruption of glutamate homeostasis caused by long-term cocaine use restoring function of the cystine-glutamate exchanger in glial cells and reversing the downregulated GLT-1 receptor. Current data suggest promising potential for NAC as an anti-relapse agent, as a double-blind placebo trial was mainly negative, except in the subgroup of patients who were already abstinent. An optimal dose for relapse prevention may be one that restores extrasynaptic glutamate to physiological levels and predominantly activates mGluR2 and 3, but not mGluR5 receptors, which are linked to relapse. NAC may be better suited for avoiding relapse in already abstinent subjects.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Nocito Echevarria MA,Andrade Reis T,Ruffo Capatti G,Siciliano Soares V,da Silveira DX,Fidalgo TMdoi
10.1016/j.psychres.2017.02.024subject
Has Abstractpub_date
2017-05-01 00:00:00pages
197-203eissn
0165-1781issn
1872-7123pii
S0165-1781(16)30886-1journal_volume
251pub_type
杂志文章,评审abstract::Family environment is a pathogenic factor of borderline personality disorder (BPD). However, the personality traits of patients with BPD and their parents have never been assessed using the same instrument and then examined for relationships. In the present study, we explored the temperament and character traits of BP...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2007.10.010
更新日期:2009-01-30 00:00:00
abstract::Antisocial and violent behaviour have been associated with both structural and functional brain abnormalities in the frontal and the temporal lobes. The aim of the present study was to assess cortical thickness in offenders undergoing forensic psychiatric assessments, one group with psychopathy (PSY, n=7) and one grou...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.12.011
更新日期:2012-08-01 00:00:00
abstract::Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pa...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.08.083
更新日期:2017-12-01 00:00:00
abstract::Repetitive transcranial magnetic stimulation (rTMS) is currently undergoing active investigation for use in the treatment of major depression. Recent research has indicated that current methods used to localize the site of stimulation in dorsolateral prefrontal cortex (DLPFC) are significantly inaccurate. However, lit...
journal_title:Psychiatry research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.pscychresns.2006.04.006
更新日期:2006-11-22 00:00:00
abstract::The anterior cingulate is a key component of neural networks subserving attention and emotion regulation, functions often impaired in patients with psychosis. The study aimed to examine anterior cingulate volumes and sulcal morphology in a group of patients with childhood-onset schizophrenia (COS) compared with contro...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2005.01.001
更新日期:2005-04-30 00:00:00
abstract::Low body mass index (BMI<18/18.5) is utilized as a mandated cutoff for professional fashion model employment, based on assumptions that low BMI indicates eating disorder pathology. No previous studies have examined the association between experimenter-measured BMI and eating disorder symptomatology in professional fas...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113358
更新日期:2020-11-01 00:00:00
abstract::To evaluate the relationships between problematic Internet use (PIU) and suicidal ideation (SI) among adolescents, we encompassed 12,507 participants (16.6 ± 0.8 years). The occurrence of mood disorders, quality of life (QOL), personality traits and SI were compared in adolescents with and without PIU. Multilevel logi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.112963
更新日期:2020-08-01 00:00:00
abstract::We developed a semiautomatic method termed "cortical circumferential profiling" for objective analysis of cerebral cortex function in emission tomographic neuroimaging studies. This method treats cortex as a continuous ring near the outer brain edge. A computer algorithm samples the cortex at 60 contiguous, equiangula...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(91)90008-e
更新日期:1991-11-01 00:00:00
abstract::We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant...
journal_title:Psychiatry research
pub_type: 杂志文章,meta分析
doi:10.1016/j.psychres.2013.05.017
更新日期:2013-10-30 00:00:00
abstract::Serotonin constrains a broad array of animal and human behavior and may also inhibit the expression of mood or affective states among humans. For the most part, this research has focused on the association of central serotonergic function with negative affectivity (i.e., anxiety, depression, hostility), with less atte...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2004.06.010
更新日期:2004-11-30 00:00:00
abstract::Knowledge on associations between ultra-high risk (UHR) for developing psychosis and on non-psychotic psychopathology in help-seeking populations is limited with respect to differences between male and female patients. The present study tests the hypothesis that both social anxiety and depression are highly prevalent ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.01.012
更新日期:2013-10-30 00:00:00
abstract::Malignant self-regard (MSR) was proposed as a particular type of self-structure that may account for similarities among a set of clinically relevant Personality Disorders (PDs) such as masochistic/self-defeating and depressive PDs that yet have failed to be adequately represented in the diagnostic manuals. The investi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.10.059
更新日期:2018-12-01 00:00:00
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journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.08.074
更新日期:2017-12-01 00:00:00
abstract::One inhalation of 35% CO2 in oxygen was administered to 36 patients with anxiety disorders and 14 healthy controls. Eighteen patients had a diagnosis of panic disorder (PD) and 18 of obsessive-compulsive disorder (OCD). As a placebo control for CO2, compressed air was administered in a double-blind design. Immediately...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(90)90121-k
更新日期:1990-02-01 00:00:00
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journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(00)00216-x
更新日期:2000-11-20 00:00:00
abstract:AIMS:Memory impairment in psychosis may be mediated through detrimental effects of hypothalamic-pituitary-adrenal (HPA) axis function. This study prospectively investigated the relationship between cortisol, sulphate dehydroepiandrosterone (DHEA(S) and cortisol: DHEA(S) ratio and memory in 35 first-episode psychosis (F...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.11.044
更新日期:2018-02-01 00:00:00
abstract::Prior studies have confirmed a bias against disconfirmatory evidence (BADE) in schizophrenia which has been associated with delusions. However, its role in the pathogenesis of psychosis is yet unclear. The objective was to investigate BADE for the first time in subjects with an at-risk-mental-state for psychosis (ARMS...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.02.028
更新日期:2016-04-30 00:00:00
abstract::Schema theory and therapy may be an additional therapeutic approach to identify and treat chronic psychological problems, namely early maladaptive schemas (EMSs), in patients with obsessive-compulsive disorder (OCD) and panic disorder (PAD). In the current study, we investigated the characteristics in EMSs between pat...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.11.015
更新日期:2015-12-30 00:00:00
abstract::The usefulness of motor subtypes of delirium is unclear due to inconsistency in sub-typing methods and a lack of validation with objective measures of activity. The activity of 40 patients was measured with 24 h accelerometry monitoring. Patients with Diagnostic and Statistical Manual of Mental Disorders, fourth editi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2009.04.010
更新日期:2010-06-30 00:00:00
abstract::Patients with Alzheimer's disease (AD) and schizophrenia display cognitive, behavioural disturbances and morphological abnormalities. Although these latter reflect progressive neurodegeneration in AD, their significance in schizophrenia is still unclear. We explored the patterns of hippocampal and amygdalar atrophy in...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2010.12.015
更新日期:2011-05-31 00:00:00
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journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(83)90006-9
更新日期:1983-08-01 00:00:00
abstract::Behavioral changes in 44 subjects with well-characterized mild senile dementia of the Alzheimer's type (SDAT) and 16 subjects with only questionable SDAT were compared to a control group of 58 subjects. Answers to both open-ended questions and personality items from the Blessed Dementia Scale were examined. Seventeen ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(87)90062-x
更新日期:1987-05-01 00:00:00
abstract::Panic disorder (PD) is characterized by anticipatory anxiety and panic, both causing physiological arousal. We investigated the differential responses between anticipatory anxiety and panic in PD and healthy controls (HC). Subjects (15 PD and 30 HC) received an injection of a respiratory stimulant, doxapram, with a hi...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2015.03.001
更新日期:2015-05-30 00:00:00
abstract::The purpose of this study was to assess whether premorbid signs, such as thought disorder, could predict the subsequent manifestation of psychiatric disorders. A group of 75 adoptees at high genetic risk for schizophrenia and 96 low-risk adoptees without any psychiatric disorder at the initial assessment were assessed...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2004.01.002
更新日期:2004-03-15 00:00:00
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journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.08.007
更新日期:2007-12-03 00:00:00
abstract::Previous studies on the factorial structure of the Patient Health Questionnaire (PHQ-9) have yielded divergent results, and there is no consensus on which factorial structure provides a more adequate fit. In Colombia, no precise method to estimate the factorial structure of the PHQ-9 has been used. The purpose of this...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.08.071
更新日期:2018-11-01 00:00:00
abstract::A central program for recruiting "normal" control subjects is examined by considering the yield of subjects who meet criteria for "healthy" as defined by their personal and family histories of mental disorders. Of the 267 applicants, 30.3% have no lifetime diagnoses, 41.2% are currently healthy with a history of menta...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(94)90057-4
更新日期:1994-09-01 00:00:00
abstract::The etiopathogenesis of eating disorders (EDs) is complex and still not well understood. Biological, psychological and environmental factors (e.g. childhood abuse) have all been considered to be involved in the onset and the persistence of EDs. The hypothalamic-pituitary-adrenal (HPA) axis is a relevant biological fac...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.03.046
更新日期:2019-05-01 00:00:00
abstract::Beta-Endorphin (0.3 or 0.6 nanomoles) was infused into the A10-ventral tegmental area (VTA) of male Wistar rats previously treated for 6 days with either morphine sulfate or lactose via subcutaneously implanted silastic pellets. Beta-Endorphin microinfusions occurred at 24 and 96 hours after pellets were removed. Prof...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(92)90088-k
更新日期:1982-10-01 00:00:00
abstract::Most investigators have measured binding of 3H-imipramine to platelet membranes, but some of the preparations may have contained varying proportions of intracellular protein because of contamination with incompletely lysed platelets. Since binding to membranes has been expressed with reference to the amount of protein...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(88)90070-4
更新日期:1988-11-01 00:00:00