Heart rate and respiratory response to doxapram in patients with panic disorder.


:Panic disorder (PD) is characterized by anticipatory anxiety and panic, both causing physiological arousal. We investigated the differential responses between anticipatory anxiety and panic in PD and healthy controls (HC). Subjects (15 PD and 30 HC) received an injection of a respiratory stimulant, doxapram, with a high rate of producing panic attacks in PD patients, or an injection of saline. PD subjects had significantly higher scores in anxiety and panic symptoms during both conditions. Analysis of heart rate variability (HRV) indices showed higher sympathetic activity (LF) during anticipatory anxiety and panic states, an increase in the ratio of LF/HF during the anticipatory and panic states and a decrease in parasympathetic (HF) component in PD patients. During doxapram PD subjects increased their LF/HF ratio while HC had a reduction in LF/HF. Parasympathetic component of HRV was lower during anticipatory anxiety in PD. In general, PD showed greater sympathetic and psychological responses related to anxiety and sensations of dyspnea, reduced parasympathetic responses during anticipatory and panic states, but no differences in respiratory response. This confirms previous studies showing that PD patients do not have an intrinsic respiratory abnormality (either heightened or dysregulated) at the level of the brain stem but rather an exaggerated fear response.


Psychiatry Res


Psychiatry research


Martinez JM,Garakani A,Aaronson CJ,Gorman JM




Has Abstract


2015-05-30 00:00:00














  • Increased binding of 5-HT1A receptors in a dissociative amnesic patient after the recovery process.

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kitamura S,Yasuno F,Inoue M,Kosaka J,Kiuchi K,Matsuoka K,Kishimoto T,Suhara T

    更新日期:2014-10-30 00:00:00

  • Effect of pulse loading with clomipramine on EEG sleep.

    abstract::Two different initial dosing regimens with clomipramine (CMI) were used to compare early response indicators and dose strategies. Thirty-two inpatients with major depressive disorder were randomized in a double-blind protocol. The pulse-loading group received 150 and 200 mg of CMI on 2 consecutive evenings and then re...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kupfer DJ,Pollock BG,Perel JM,Miewald JM,Grochocinski VJ,Ehlers CL

    更新日期:1994-11-01 00:00:00

  • Application of the seven-factor model of personality to early childhood.

    abstract::The seven-factor model of personality developed by Cloninger and colleagues describes personality as a function of developmental aspects of character superimposed on heritable dimensions of temperament. The objective of this study was to determine whether this model could be applied to early childhood. We tested a pre...

    journal_title:Psychiatry research

    pub_type: 杂志文章


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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Li M,D'Arcy C,Meng X

    更新日期:2019-03-01 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kang C,Zhou H,Yang J,Yang R,Sun N,Wang S,Yang C,Han D,Srihari VH

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  • Tourette's syndrome, trichotillomania, and obsessive-compulsive disorder: how closely are they related?

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    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Ferrão YA,Miguel E,Stein DJ

    更新日期:2009-11-30 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Chen S,Xia W,Li L,Liu J,He Z,Zhang Z,Yan L,Zhang J,Hu D

    更新日期:2006-01-30 00:00:00

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    pub_type: 杂志文章


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    更新日期:2011-05-30 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Fotiou F,Fountoulakis KN,Iacovides A,Kaprinis G

    更新日期:2003-06-15 00:00:00

  • Choline chloride effects on memory: correlation with the effects of physostigmine.

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Mohs RC,Davis KL

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    pub_type: 杂志文章


    authors: Roth WT,Pfefferbaum A,Kelly AF,Berger PA,Kopell BS

    更新日期:1981-04-01 00:00:00

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    pub_type: 杂志文章


    authors: Maes M,Vandewoude M,Schotte C,Maes L,Martin M,Blockx P

    更新日期:1990-11-01 00:00:00

  • Influence of age on the parasympatholytic property of tricyclic antidepressants.

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    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Lehofer M,Moser M,Hoehn-Saric R,McLeod D,Hildebrandt G,Egner S,Steinbrenner B,Liebmann P,Zapotoczky HG

    更新日期:1999-02-22 00:00:00

  • Association between hair lead levels and autism spectrum disorder in children: A systematic review and meta-analysis.

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    pub_type: 杂志文章,meta分析


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    更新日期:2019-06-01 00:00:00

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    journal_title:Psychiatry research

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    authors: Kremen WS,Faraone SV,Seidman LJ,Pepple JR,Tsuang MT

    更新日期:1998-07-13 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Roy A,Bissette G,Williams R,Berman J,Gonzalez B

    更新日期:2003-03-25 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


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    更新日期:2016-06-30 00:00:00

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    authors: Debernard L,Melzer TR,Alla S,Eagle J,Van Stockum S,Graham C,Osborne JR,Dalrymple-Alford JC,Miller DH,Mason DF

    更新日期:2015-12-30 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章,多中心研究


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    journal_title:Psychiatry research

    pub_type: 杂志文章


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    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究


    authors: Bahk WM,Park S,Jon DI,Yoon BH,Min KJ,Hong JP

    更新日期:2011-10-30 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Levy AB,Dixon KN,Schmidt H

    更新日期:1987-03-01 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Sierra M,Medford N,Wyatt G,David AS

    更新日期:2012-05-15 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Wu Y,Mai N,Zhong X,Wen Y,Zhou Y,Li H,Shang D,Hu L,Chen X,Chen B,Zhang M,Ning Y

    更新日期:2018-11-01 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cooke MA,Peters ER,Fannon D,Aasen I,Kuipers E,Kumari V

    更新日期:2010-07-30 00:00:00

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    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rocca P,Marchiaro L,Rasetti R,Rivoira E,Bogetto F

    更新日期:2002-10-10 00:00:00

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    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Conca A,Prapotnik M,Peschina W,König P

    更新日期:2003-11-30 00:00:00

  • Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder.

    abstract::Although brain lactate levels are typically low and difficult to measure, a few previous investigators have reported that brain lactate levels are elevated in patients with bipolar disorder. The present study investigated the distribution of lactate in bipolar and healthy brains using 2D proton magnetic resonance spec...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Chu WJ,Delbello MP,Jarvis KB,Norris MM,Kim MJ,Weber W,Lee JH,Strakowski SM,Adler CM

    更新日期:2013-09-30 00:00:00