Abstract：
:Treatment in early intervention services (EIS) seems superior to treatment as usual on several outcomes, but the extent of heterogeneity in response is unclear. In this study, treatment response trajectories up to 2 years in first-episode psychosis (FEP) patients enrolled in an Italian early intervention service (EIS) have been quantified. The 24-item Brief Psychiatric Rating Scale (BPRS) was used to quantify treatment response up to 2 years in 129 participants. Conditional growth modeling and latent class growth analysis were used to test changes over time in the BPRS and separation into independent classes over time. Group differences were tested on socio-demographic and clinical variables known to be related to outcome in psychosis. Scores on the BPRS showed a statistically significant decrease in overall scores across all tested models. Four trajectories were identified across 2 years. Most patients showed a progressive decrease in the BPRS scores; a scant fraction showed a more stepped decrease from very high levels of psychopathology. No potential predictor was statistically related to the time course of BPRS scores. Most patients that undergo treatment within an EIS are characterized by amelioration, but patients that have higher baseline scores of psychopathology require more intensive treatment.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Meneghelli A,Barbera S,Meliante M,Monzani E,Preti A,Cocchi A,Percudani Mdoi
10.1016/j.psychres.2020.113200subject
Has Abstractpub_date
2020-09-01 00:00:00pages
113200eissn
0165-1781issn
1872-7123pii
S0165-1781(20)30813-1journal_volume
291pub_type
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