Abstract:
:We investigated spontaneous eye-blink rates in 19 drug-free patients with winter seasonal affective disorder (SAD) and 18 normal control subjects. At baseline, there were no significant differences between the two groups (mean +/- SD blink rate: 15/minute +/- 8 vs. 15/minute +/- 7). Light therapy (10,000 lux: 1 hour each morning for 1 week) produced no significant change in mean (+/- SD) blink rates either in 10 SAD patients (13/minute +/- 8 vs. 10/minute +/- 7) or in 12 normal control subjects (15/minute +/- 6 vs. 14/minute +/- 6). A post hoc exploratory analysis of the effect of light therapy on premenopausal female subjects (5 patients and 9 control subjects) showed a significant decrease in mean (+/- SD) blink rate in the patients after treatment (17 +/- 6 vs. 12 +/- 8 compared with 15 +/- 7 vs. 16 +/- 5). These results do not support the idea that an elevated blink rate may be a general biological marker in SAD, but they suggest a possible link between light treatment and mechanisms that regulate blink rate in premenopausal SAD patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Barbato G,Moul DE,Schwartz P,Rosenthal NE,Oren DAdoi
10.1016/0165-1781(93)90057-nsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
79-85issue
1eissn
0165-1781issn
1872-7123pii
0165-1781(93)90057-Njournal_volume
47pub_type
临床试验,杂志文章abstract::Previous studies on the factorial structure of the Patient Health Questionnaire (PHQ-9) have yielded divergent results, and there is no consensus on which factorial structure provides a more adequate fit. In Colombia, no precise method to estimate the factorial structure of the PHQ-9 has been used. The purpose of this...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.08.071
更新日期:2018-11-01 00:00:00
abstract::The aim of this study was to assess the association between anhedonia and metabolic syndrome (MetS) in a well-characterized community sample of individuals with a current depressive episode. This is a cross-sectional study with young adults aged 24-30 years old. Depressive episode and the presence of anhedonia was ass...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.08.009
更新日期:2019-01-01 00:00:00
abstract::Patients with borderline personality disorder (BPD) suffer from various impairments in emotional functioning such as affective instability, inappropriate anger and unstable relationships. These deficits may influence two fundamental motivational systems, the behavioral inhibition system (BIS) and behavioral activation...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.04.027
更新日期:2014-08-15 00:00:00
abstract::Twenty-three patients meeting DSM-III criteria for agoraphobia with panic attacks and 14 age-, race-, and sex-matched nonanxious controls were tested in the laboratory and on a test walk in a shopping mall. The patients were tested before and after about 15 weeks of treatment with placebo and exposure therapy, imipram...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/0165-1781(88)90145-x
更新日期:1988-04-01 00:00:00
abstract::The objective of the study was to examine the relationship between an index of central dopamine function and electroretinographic (ERG) blue cone amplitudes in cocaine-dependent patients. Thus, 17 recently abstinent cocaine-dependent patients had an ERG performed. They also had a lumbar puncture for determination of c...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00323-2
更新日期:2003-02-15 00:00:00
abstract::Adult attention deficit hyperactivity disorder (ADHD) is frequently associated with borderline personality disorder (BPD). As both disorders share some core clinical features they are sometimes difficult to distinguish from one another. The present work aimed to investigate differences in the expression of impulsivity...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.03.006
更新日期:2014-06-30 00:00:00
abstract::Wells's (2009) metacognitive theory suggests that inflexible and recurrent styles of thinking in response to negative thoughts, feelings, and beliefs underlie mood and anxiety symptoms. Wells termed such styles of thinking as the cognitive attentional syndrome (CAS). Using a clinical sample (N=132) of patients with ei...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.04.020
更新日期:2013-11-30 00:00:00
abstract::The cavum septum pellucidum (CSP) is a fluid-filled cavity in the thin midline structure of the septum pellucidum. The CSP has been linked to several neurodevelopmental disorders, but it also occurs as a result of head injury. The aims were to assess the presence and characterization of the CSP in youth with traumatic...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2013.03.001
更新日期:2013-09-30 00:00:00
abstract::The aim of this exploratory study was to investigate facial affect in adolescent females with anorexia nervosa (AN). Evoked facial affect was recorded whilst AN and control participants (n=34) viewed emotional films. Significantly less facial affect was found in AN adolescents, despite reporting no differences in subj...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.07.057
更新日期:2014-12-15 00:00:00
abstract::Although several studies have detected differences in clinical features among specific phobias, there is a shortage of detailed national data on the on the DSM-IV SP subtypes, particularly in the Asian population. To examine the prevalence, demographic and other correlates, and co-morbidities of DSM-IV SP subtypes in ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.12.025
更新日期:2013-10-30 00:00:00
abstract::Blood from chronic schizophrenic patients in two hospitals (A and B) and from institutional and noninstitutional controls was analyzed for platelet monoamine oxidase (MAO) activity toward three different substrates (tryptamine, phenylethylamine, and p-tyramine) and for plasma levels of conjugated and unconjugated phen...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(82)90042-7
更新日期:1982-02-01 00:00:00
abstract::The Edinburgh High Risk Project is a longitudinal study of brain structure (and function) in subjects at high risk of developing schizophrenia in the next 5-10 years for genetic reasons. In this article we describe the methods of volumetric analysis of structural magnetic resonance images used in the study. We also co...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(99)00012-8
更新日期:1999-07-30 00:00:00
abstract::Intelligence has been suggested as a suitability factor for short-term therapy whereas its possible effect on short-term versus long-term therapy still is unknown. The aim of this study was to compare the prediction of intelligence on the level of psychiatric symptoms and psychosocial functioning in psychotherapies of...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2014.10.011
更新日期:2014-12-30 00:00:00
abstract::Accurate drug use assessment is vital to understanding the prevalence, course, treatment needs, and outcomes among individuals with schizophrenia because they are thought to remain at long-term risk for negative drug use outcomes, even in the absence of drug use disorder. This study evaluated self-report and biologica...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.05.028
更新日期:2012-12-30 00:00:00
abstract::Neuroleptic dosage was reduced by 10% every 2 weeks in five male hyponatremic polydipsic patients with schizophrenia. Mean dose fell from 1980 +/- 1289 to 631 +/- 135 chlorpromazine equivalents/day over a mean of 12.2 weeks until behavioral relapse occurred. During this time, serum sodium did not vary from baseline le...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(96)02793-x
更新日期:1996-07-31 00:00:00
abstract::While social anhedonia is a promising indicator of vulnerability to schizophrenia, it remains uncertain whether anhedonia is a core feature of schizotypy or merely a secondary associated characteristic. This issue was examined by comparing dimensional scores on schizophrenia spectrum personality disorder symptoms deri...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.06.002
更新日期:2007-01-15 00:00:00
abstract::Correlations between normalized regional cerebral metabolic rates for glucose, determined by positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose, were used to investigate functional associations between pairs of brain regions in 18 adult patients with primary obsessive-compulsive disorder (OCD) of childho...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(91)90014-h
更新日期:1991-12-01 00:00:00
abstract::The impact of stressful experiences during gestation or early life, leading to increased psychiatric disorders susceptibility, is currently well described in literature, however, few data are available on the association between obstetrical complications and later development of specific diagnoses or clinical features...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.05.014
更新日期:2016-07-30 00:00:00
abstract::Low plasma total testosterone (T) levels may influence the sense of well-being and produce depressive symptomatology, increasing the risk of suicide. In a previous study, we reported reduced serum T levels in male psychiatric patients after a suicide attempt. The reduction was more pronounced in subjects who used viol...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2008.08.001
更新日期:2009-11-30 00:00:00
abstract::The pathophysiology of pediatric bipolar disorder (PBD) impacts both affective and cognitive brain systems. Understanding disturbances in the neural circuits subserving these abilities is critical for characterizing developmental aberrations associated with the disorder and developing improved treatments. Our objectiv...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2007.10.003
更新日期:2008-04-15 00:00:00
abstract::Depression is associated with three distinct alterations in memory functioning: mood-congruent recall, over-generality, and intrusive memories. These concern the autobiographical memory system, yet no previous studies have examined the neural correlates of autobiographical memory function in depression. In the present...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2011.08.008
更新日期:2012-02-28 00:00:00
abstract::Negative life events are elevated in suicidal populations. Diathesis-stress and kindling effects models suggest different mechanisms by which negative life events increase suicide risk. Different forms of negative life events - risk-taking behaviors and stressors - may have different effects on non-fatal suicide attem...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.09.032
更新日期:2018-12-01 00:00:00
abstract::Baseline body mass index (BMI), baseline BMI status (normal, overweight, obese) and early (1 month) BMI increases were tested as predictors of 6- and 12-month increases in glucose and lipid measures in 82 olanzapine (OLZ)- and 78 risperidone (RIS)-treated patients with schizophrenia, schizoaffective disorder, or bipol...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2011.07.008
更新日期:2011-09-30 00:00:00
abstract::This investigation aimed to determine whether impaired insight influences the validity of self-report test scores in schizophrenia and schizoaffective disorder. 274 outpatients enrolled in work rehabilitation completed the Beck Depression Inventory (BDI), Eysenck Personality Questionnaire (EPQ), Bell Object Relations ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.04.012
更新日期:2007-05-30 00:00:00
abstract::Vascular dementia (VaD) is characteristic of chronic brain ischemia and progressive memory decline, which has a high incidence in the elderly. However, there are no effective treatments for VaD, and the underlying mechanism of its pathogenesis remains unclear. This study investigated the effects of a synthetic cannabi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.06.012
更新日期:2018-09-01 00:00:00
abstract::Unhealthy behaviors and physical morbidity are more common among trauma survivors, especially those who suffer from posttraumatic stress disorder (PTSD). This study looked at the underexplored relationships between parental PTSD, unhealthy behaviors and aging of trauma survivors' offspring. Dyads of parents (mean age ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.11.060
更新日期:2019-01-01 00:00:00
abstract::We examined the short-term efficacy of two treatments using environmental supports (e.g. signs, alarms, pill containers, and checklists) to improve target behaviors in individuals with schizophrenia. 120 participants were randomized into one of the following three treatment groups: 1) Cognitive Adaptation Training (CA...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2008.03.016
更新日期:2009-07-30 00:00:00
abstract::The current study aims to further evaluate the psychometric properties of the Maryland Assessment of Recovery in Serious Mental Illness (MARS), a relatively new instrument designed to assess personal recovery status in individuals with serious mental illness. Two hundred and fifty individuals with serious mental illne...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.03.031
更新日期:2016-05-30 00:00:00
abstract::The aim of this study was to compare childhood trauma scores domains between Major Depressive Disorder (MDD) patients with and without suicide risk. This is cross-sectional study including a clinical sample of adults (18-60 years) diagnosed with MDD through the Mini International Neuropsychiatric Interview Plus versio...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.11.002
更新日期:2016-12-30 00:00:00
abstract::MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop fa...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.01.006
更新日期:2016-02-28 00:00:00