Abstract：
:Depression is associated with three distinct alterations in memory functioning: mood-congruent recall, over-generality, and intrusive memories. These concern the autobiographical memory system, yet no previous studies have examined the neural correlates of autobiographical memory function in depression. In the present study we used functional magnetic resonance imaging (fMRI) to assess depressed and control participants during an autobiographical memory task. In their first visit to the laboratory, participants wrote a narrative account of a distressing event. Participants were scanned during the second visit while they viewed old items from their narrative and new words or phrases in a recognition memory task. Activity common to both groups during the successful identification of personal emotional memories was observed in regions previously associated with autobiographical memory retrieval. Reduced activity in the depressed group was observed in three regions of the prefrontal cortex associated with cognitive, emotional, and memory inhibition. These results are consistent with a failure by depressed individuals to inhibit task-irrelevant information during an autobiographical memory task.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Whalley MG,Rugg MD,Brewin CRdoi
10.1016/j.pscychresns.2011.08.008subject
Has Abstractpub_date
2012-02-28 00:00:00pages
98-106issue
2eissn
0165-1781issn
1872-7123pii
S0925-4927(11)00301-5journal_volume
201pub_type
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