Abstract：
:Dopaminergic abnormalities in bulimia nervosa have been reported in some studies, but results are not consistent across studies. In the present study, clinical characteristics, plasma level of homovanillic acid (pHVA) and two scales - the Eating Attitudes Test (EAT) and the Beck Depression Inventory (BDI) - were assessed in 36 adolescent bulimia nervosa patients (mean age16.3 years, S.D. 1.1) who were consecutively seen on an Eating Disorder Unit. Levels of pHVA were also measured in 16 healthy control adolescents from the general population. Patients had significantly higher mean pHVA than controls. Eighteen patients (50%) had a pHVA level equal to or higher than the mean of control subjects plus one standard deviation, and this group of patients had significantly higher mean BDI scores and non-significantly higher mean EAT scores, although they did not differ from the other patients in age, time elapsed since the onset of disorder, body mass index and number of binges or vomits. Moreover, in logistic regression analysis the BDI score proved to be an independent predictor of high pHVA. The level of pHVA is increased in bulimia nervosa patients with high scores on measures of depressive and eating symptomatology.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Castro-Fornieles J,Deulofeu R,Martínez-Mallen E,Baeza I,Fernández L,Lázaro L,Toro J,Vila M,Bernardo Mdoi
10.1016/j.psychres.2008.06.046subject
Has Abstractpub_date
2009-12-30 00:00:00pages
241-4issue
2-3eissn
0165-1781issn
1872-7123pii
S0165-1781(09)00029-8journal_volume
170pub_type
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