Abstract：
:The study of distinctive and consistent behaviors in the most common genetic syndromes with intellectual disability is useful to explain abnormalities or associated psychiatric disorders. The behavioral phenotypes revealed outcomes totally or partially specific for each syndrome. The aim of our study was to compare similarities and differences in the adaptive profiles of the five most frequent genetic syndromes, i.e. Down syndrome, Williams syndrome, Angelman syndrome, Prader-Willi syndrome, and Fragile-X syndrome (fully mutated), taking into account the relation with chronological age and the overall IQ level. The research was carried out using the Vineland Adaptive Behavior Scale (beside the Wechsler Intelligence scales to obtain IQ) with a sample of 181 persons (107 males and 74 females) showing genetic syndromes and mental retardation. Syndrome-based groups were matched for chronological age and mental age (excluding the Angelman group, presenting with severe mental retardation). Similarities and differences in the adaptive profiles are described, relating them to IQs and maladaptive behaviors. The results might be useful in obtaining a global index of adjustment for the assessment of intellectual disability level as well as for educational guidance and rehabilitative plans.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Di Nuovo S,Buono Sdoi
10.1016/j.psychres.2011.03.015subject
Has Abstractpub_date
2011-10-30 00:00:00pages
440-5issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(11)00238-1journal_volume
189pub_type
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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