Abstract：
:Pituitary volume in humans has been reported to change size in response to experimental manipulations of photoperiod, and to be increased during an episode of non-seasonal major depression. We wanted to determine whether pituitary volume changes either across the seasons or during an episode of winter depression. Nineteen patients with winter-seasonal affective disorder and 19 sex-, age-, height-, and weight-matched controls underwent magnetic resonance imaging of the pituitary gland in both winter and summer. Images were obtained using 0.7-mm contiguous slices and the areas of all slices were summed to compute the final volume for each gland. We found no main effects or interactions involving either diagnosis or season in our primary analysis. In a post-hoc analysis, we found a trend towards a season x gender effect (P = 0.06), such that pituitary volume increased slightly (+4.0%) across seasons in women, whereas it decreased slightly (-4.3%) across seasons in men. The results suggest that neither winter depression nor the change of seasons is associated with a significant change in pituitary size.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Schwartz PJ,Loe JA,Bash CN,Bove K,Turner EH,Frank JA,Wehr TA,Rosenthal NEdoi
10.1016/s0925-4927(97)00015-2subject
Has Abstractpub_date
1997-07-04 00:00:00pages
151-7issue
3eissn
0165-1781issn
1872-7123journal_volume
74pub_type
杂志文章abstract：:Stressful life events (SLEs) are associated with increased risk for suicidal behavior. Less is known regarding the intensity of SLEs and how this may vary as a function of suicide attempt history. As a large percentage of suicide decedents do not have a history of suicidal behavior, SLEs precipitating suicide may help...
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pub_type： 杂志文章
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