当前位置： SCI文献检索 > PSYCHIATRY RESEARCH期刊下所有文献 > Aggression as an independent entity even in psychosis - The role of cortisol.

Aggression as an independent entity even in psychosis - The role of cortisol.

Abstract：

:Aggression is a common entity in psychiatric disorders, particularly psychotic disorders. Glucocorticoid hypofunction has been linked to abnormal forms of aggressive behavior in various studies in a 'possibly causal' role. We hypothesise that aggression, even among those having psychosis is associated with glucocorticoid alterations similar to those who are aggressive but not psychotic. To our knowledge, this is the first study attempting to look at the cortisol functioning in relation to both aggression and psychosis. The present study included 80 participants divided into four groups depending upon presence or absence of aggression and psychosis. Morning cortisol, afternoon cortisol and their variability were measured using ELISA. The groups were compared on measures of aggression, psychosis, morning cortisol, afternoon cortisol and their variability using standard statistical instruments. The present study found lower levels of morning cortisol, afternoon cortisol and cortisol variability among the aggressive group (vs. non aggressive group) and among the diseased group (vs. non diseased group). The differences were most marked for cortisol variability which was related to both aggression and psychosis independently. There were statistically significant correlation between cortisol variability and aggression, which was retained even after controlling for psychosis. There was no significant correlation of cortisol variability with psychosis severity (after controlling for aggression score) or with age, gender or duration of psychosis. We conclude that aggression, even among patients with psychosis, is an independent entity characterized by lower levels of morning cortisol and cortisol variability. The etio-pathology may lie in some altered neuro-immune parameters executed by cortisol and psychosis as trigger.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Das S,Sengupta S,Pathak K,Sah D,Mehta S,Avinash PR,Baruah A,Deuri SK,Sarmah A,Gogoi V,Kalita KN,Hazarika J

doi

10.1016/j.psychres.2017.11.002

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

405-411

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(17)30388-8

journal_volume

259

pub_type

杂志文章

在线工具

Aggression as an independent entity even in psychosis - The role of cortisol.