Abstract：
:Haloperidol and reduced haloperidol plasma concentrations were measured in age-matched Chinese and non-Chinese patients (n = 32). Steady-state plasma concentrations were obtained 10-12 hours after the bedtime dose. Haloperidol and reduced haloperidol concentrations were measured by liquid chromatography and radioimmunoassay. Haloperidol plasma concentrations did not significantly differ between the populations, but reduced haloperidol levels were 3 times greater in non-Chinese patients than in Chinese patients. The incidence of extrapyramidal side effects was higher in Chinese patients (18 vs. 10), while non-Chinese patients with extrapyramidal symptoms had higher reduced haloperidol plasma levels. Logistic regression analysis revealed that ethnicity and reduced haloperidol/haloperidol ratios were important variables in predicting extrapyramidal symptoms. These results suggest that the metabolism and disposition of haloperidol and reduced haloperidol could differ among ethnic populations.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Jann MW,Chang WH,Davis CM,Chen TY,Deng HC,Lung FW,Ereshefsky L,Saklad SR,Richards ALdoi
10.1016/0165-1781(89)90170-4subject
Has Abstractpub_date
1989-10-01 00:00:00pages
45-52issue
1eissn
0165-1781issn
1872-7123pii
0165-1781(89)90170-4journal_volume
30pub_type
杂志文章abstract：:The immense burden of health conditions in children that is associated with mental disorders worldwide is increasingly being recognized. In comparison, the burden of disability associated with children's impairments of psychological functions (IPFs) is not well documented. The goal of this population-based study was t...
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