Abstract：
:Although many treatments for Major Depressive Disorder (MDD) exist, only half of all patients respond to initial trial of pharmacotherapy and only a third will achieve remission with that trial. First-line therapies for the management of MDD include psychotherapy or pharmacotherapy, alone or in combination. Given the disappointing rates of response and remission to initial therapy, clinicians are looking for methods to improve the management of MDD, such as through the use of adjunct therapies. The first article in this series, by Katzman and Chokka, discusses gaps in the treatment of MDD and proposes measures to change and strengthen future practice guidelines. Epstein et al. summarize the findings of clinical studies, systematic analyses, and reviews of trials supporting the use of adjunct therapy for the treatment of MDD. Velehorschi et al. review emerging research identifying common pathophysiological processes between MDD and three of its comorbidities. Lastly, Cameron and Habert highlight the challenges that primary care physicians face in the management of MDD. Ultimately, the goal of treatment is to not only relieve symptoms of MDD, but achieve sustained remission. This supplement was written to address the issues of less than ideal outcomes and approaches to enhancing response and remission rates.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Katzman MAdoi
10.1016/S0165-1781(14)70001-0subject
Has Abstractpub_date
2014-12-01 00:00:00pages
S1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(14)70001-0journal_volume
220 Suppl 1pub_type
社论abstract：:It is estimated that between 1.7 and 2.6 million people have had intermittent explosive disorder (IED) during their life in the United States alone. Co-occurring psychiatric disorders are very common in IED, being major depressive disorder arguably the most common. The objective of this study was to examine the clinic...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.001
更新日期：2018-04-01 00:00:00
abstract：:We studied the complexity of the electroencephalogram (EEG) in schizophrenic patients by estimating the first Lyapunov exponent (L1), which might serve as an indicator of the specific brain function in schizophrenia. We recorded the EEG from 25 schizophrenic patients (12 male, 13 female; age=25.1+/-7.0 years) fulfilli...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(00)00052-4
更新日期：2000-05-15 00:00:00
abstract：:Eating disorders (EDs) are psychiatric disorders associated with high morbidity and mortality. It is well established that patients with anorexia nervosa (AN) have an increased risk of premature death, whereas mortality data are lacking for the other EDs. This study aimed to establish mortality rates in a sample of ED...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.08.032
更新日期：2015-12-15 00:00:00
abstract：:Computed tomography was used to compare the following three groups: obsessive-compulsive disorder (OCD) patients with high scores on a soft neurological sign examination, OCD patients with low soft neurological sign scores, and control subjects. Neuranatomical structures were measured using quantitative volumetric ana...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(93)90026-e
更新日期：1993-10-01 00:00:00
abstract：:Sleep-related prolactin secretion and prolactin responses to the infusion of low doses of the dopamine antagonist, metoclopramide, and thyrotropin-releasing hormone were measured in 11 female volunteers before and after undertaking a diet in which they lost a mean of 3.1 kg in weight in 3 weeks. No effect of weight lo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90030-9
更新日期：1989-08-01 00:00:00
abstract：:A line of research has revealed that the influence of genes on behavioral development is closely tied to environmental experiences. Known as gene-environment interaction, research in this area is beginning to reveal that variation in parenting behaviors may moderate genetic influences on antisocial behaviors in childr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.12.032
更新日期：2012-05-30 00:00:00
abstract：:Two studies have shown that increasing the consultation of the word "suicide" in the Google search engine was associated with a subsequent increase in the prevalence of suicide attempts. The main goal of this article was to explore the trends generated by a key-word search associated with suicide, depression and bipol...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.04.022
更新日期：2015-08-30 00:00:00
abstract：:High variability in adaptive behavior in cognitively-able adults with autism spectrum disorder has been previously reported, and may be caused by the high prevalence of psychiatric comorbidity in this population. This study's goals were to examine self-reported psychiatric symptoms in students with ASD, and to identif...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.098
更新日期：2019-03-01 00:00:00
abstract：:Thirteen medication-free chronic schizophrenic patients and 11 normal control subjects were administered a trial by trial version of the Stroop Color Naming Task which evaluated separately the processes of interference and facilitation. There was no difference between the groups in the amount of interference to naming...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90105-c
更新日期：1992-02-01 00:00:00
abstract：:We have previously reported that the activity in platelets of the important antioxidant enzyme glutathione peroxidase (GPx) is inversely correlated with computed tomographic (CT) measures of brain atrophy in a population of patients with chronic schizophrenia, suggesting that low GPx may be a vulnerability factor in t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90103-c
更新日期：1990-01-01 00:00:00
abstract：:This study aimed to determine whether deficit but not nondeficit schizophrenia showed dysregulation of decision-making. In a two-choice prediction task, the subject is asked to predict whether a stimulus appears on the left or right side of a computer screen. Schizophrenia patients were divided into 12 patients with a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(03)00103-3
更新日期：2003-08-01 00:00:00
abstract：:Traditional analyses and interpretation of controlled trials rely on measures of central tendency (e.g., mean findings for treatment versus control) to detect treatment effects. These trial designs therefore emphasize homogeneity of results, with variations within the experimental or control groups treated as error to...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.112520
更新日期：2020-01-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is frequently associated with major depressive disorder, and antidepressants have been reported to ameliorate PTSD symptoms in some patients. The present study assessed the number and affinity of platelet imipramine binding sites, as a marker of the serotonin transporter complex, i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(96)02760-6
更新日期：1996-07-31 00:00:00
abstract：:The association between cognitive performance and general functioning in depression is controversial. The present study evaluated the association between cognitive dysfunction and major depressive disorder (MDD, N=70) as compared with age- and gender-matched healthy controls (n=206) and its relationship to general fun...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.12.001
更新日期：2010-04-30 00:00:00
abstract：:Traumatic experiences have been positively associated with both severity of attenuated psychotic symptoms in individuals at high risk (HR) for psychosis and transitions into psychotic disorders. Our aim was to determine what characteristics of the trauma history are more likely to be associated with individuals at HR....
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.028
更新日期：2014-12-15 00:00:00
abstract：:Platelet serotonin levels were measured in several psychiatric disorders to determine whether they distinguish among major depressive disorder (one or more depressive episodes and no manic episodes), dysthymic disorder (depressive neurosis), and schizophrenic and paranoid disorders. Serotonin levels in 141 subjects we...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90056-8
更新日期：1984-10-01 00:00:00
abstract：:In the past decade, not just right experiences (NJRE) and incompleteness (INC) have attracted renewed interest as putative motivators of symptoms in obsessive-compulsive disorder (OCD), beyond harm avoidance (HA). This study examines, in 267 non-clinical undergraduates and 47 OCD patients, the differential contributio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.012
更新日期：2016-02-28 00:00:00
abstract：:Predicting the outcome of antidepressant treatment by pre-treatment features would be of great usefulness for clinicians as up to 50% of major depressives may not have a satisfactory response in spite of adequate trials of antidepressant drugs. In the present article we compared a linear multivariate model of predicto...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.07.009
更新日期：2007-08-30 00:00:00
abstract：:Bilateral electroconvulsive therapy (ECT) seizure threshold charge averaged 162.8 and 125.1 mC at 900 and 1150 mA, respectively (p<0.02), measured in randomized balanced order (N=18). Results are consistent with stimulus dose strongly depending on current besides charge, rather than charge alone. ECT stimuli of differ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2011.12.046
更新日期：2012-06-30 00:00:00
abstract：:The tryptophan catabolite (TRYCAT) pathway is induced by indoleamine 2,3-dioxygenase (IDO), which upon activation depletes plasma tryptophan (TRP) and increases the synthesis of TRYCATs. Both phenomena are associated with somatization and depression. The aims of this study are to examine whether disorders in the TRYCA...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.09.029
更新日期：2012-04-30 00:00:00
abstract：:People who suffer from substance use disorders (SUDs) frequently report to have undergone childhood adversity that is often associated with father or mother dysfunction, or both. Yet that issue has been barely addressed in opiate dependent patients. Therefore we sought to evaluate parent-specific dysfunctional styles ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.041
更新日期：2013-12-15 00:00:00
abstract：:The lack of social contacts may be an important element in the presumed vicious circle aggravating, or at least stabilising negative symptoms in patients with schizophrenia. A European 2-year cohort study collected negative symptom scores, psychosocial functioning scores, objective social contact frequency scores and ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.039
更新日期：2015-12-30 00:00:00
abstract：:To evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) on auditory hallucinations (AH) in schizophrenia, we conducted a meta-analysis of currently available randomized control studies (RCTs). Electronic databases were searched to identify relevant literatures. Only RCTs that met the inclusion ...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2020.113141
更新日期：2020-08-01 00:00:00
abstract：:The cognitive effects of the specific norepinephrine (NE) uptake inhibitor desmethylimipramine (DMI) were examined in normal subjects. Although there were no differences in performance on drug compared to placebo treatment, there was an improvement in cognition 1 week after the drug had been discontinued. On DMI, ther...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(84)90141-0
更新日期：1984-05-01 00:00:00
abstract：:Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on threat intensity in patients with generalized social phobia (GSP) and healthy controls. GSP patients exhibited greater amygdala reactivity to threat faces at high and moderate intensities. More subtle displays of social th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.05.001
更新日期：2010-08-30 00:00:00
abstract：:Thirty depressed psychiatric inpatients, including 18 with a diagnosis of major depression, and 25 hospital staff controls were compared with respect to cellular immune function--that is, mitogen responsiveness to concanavalin A (con A), phytohemagglutinin (PHA), and pokeweed mitogen (PWM); natural killer cell (NK) ac...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90127-b
更新日期：1991-02-01 00:00:00
abstract：:Negative symptoms have been suggested to have a greater impact on real-world functioning in schizophrenia than other symptoms. We aimed to examine the relationship of specific negative symptoms components ("expressive deficits" - DE - which include alogia and blunted affect, and "avolition" - AA - which includes amoti...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.018
更新日期：2014-08-30 00:00:00
abstract：:Depression is associated with cognitive impairment and suicidality. The independent association between cognitive impairment and suicidality is less clear. We examined the relationship between suicidal ideation and cognitive impairment in a sample of 50 veterans with depressive disorder diagnoses. Using zero-inflated ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112833
更新日期：2020-01-30 00:00:00
abstract：:Neuropsychological performance was examined in a sample of 100 children between the ages of 6 and 18 years who met DSM-III-R criteria for Tourette's syndrome. Neuropsychological test scores were converted to age-corrected t scores based on published normative data. Ratings of Tourette's symptoms were also obtained. Th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90150-4
更新日期：1990-07-01 00:00:00
abstract：:Studies of schizophrenia that combine imaging and genetic approaches attempt to map structural brain anomalies associated with genetic risk variants. The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristic...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.10.001
更新日期：2008-02-28 00:00:00
