Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study.


:Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on threat intensity in patients with generalized social phobia (GSP) and healthy controls. GSP patients exhibited greater amygdala reactivity to threat faces at high and moderate intensities. More subtle displays of social threat are sufficient to evoke a fear-related neural response.


Psychiatry Res


Psychiatry research


Klumpp H,Angstadt M,Nathan PJ,Phan KL




Has Abstract


2010-08-30 00:00:00














  • Relationships between medication treatments and neuropsychological test performance in schizophrenia.

    abstract::Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and ben...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Sweeney JA,Keilp JG,Haas GL,Hill J,Weiden PJ

    更新日期:1991-06-01 00:00:00

  • Post-traumatic psychological changes among survivors of the Lushan earthquake living in the most affected areas.

    abstract::The primary objective of our study was to investigate both the negative and positive psychological changes following the Lushan earthquake, and to explore the factors associated with psychological changes. Multi-stage random sampling was used to select respondents from Lushan County, Sichuan Province, China. A simplif...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


    authors: Tang B,Kang P,Liu X,Liu Y,Liu Z,Wang B,Lv Y,Zhang L

    更新日期:2014-12-15 00:00:00

  • Uncovering psychiatric test information with graphical techniques of Exploratory Data Analysis.

    abstract::This article illustrates how Exploratory Data Analysis (EDA) can complement conventional statistical methods in evaluating psychiatric tests. Using one recent EDA computer program, we evaluated the ability of repeated psychiatric screening tests (the General Health Questionnaire [GHQ]) to predict medical and psychiatr...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Politser PE,Berwick DM,Murphy JM,Goldman PA,Weinstein MC

    更新日期:1991-10-01 00:00:00

  • Altered functional connectivity of the insular cortex across prefrontal networks in cocaine addiction.

    abstract::Interoception is theorized to be an important process mediating substance use disorders, and the insular cortex is recognized as a core neural region supporting interoception. The purpose of this study was to compare the integration of the insular cortex into prefrontal-related resting-state networks between individua...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cisler JM,Elton A,Kennedy AP,Young J,Smitherman S,Andrew James G,Kilts CD

    更新日期:2013-07-30 00:00:00

  • Investigation of automatic avoidance in displaced individuals with chronic Posttraumatic Stress Disorder (PTSD).

    abstract::Avoidance of trauma-related stimuli is a key feature of Posttraumatic Stress Disorder (PTSD). However, avoidance has almost exclusively been investigated with explicit measures targeting more strategic aspects of behavior. The aim of the present study was to examine automatic avoidance in older individuals displaced a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Wittekind CE,Behmer F,Muhtz C,Fritzsche A,Moritz S,Jelinek L

    更新日期:2015-08-30 00:00:00

  • Affiliate stigma and its association with quality of life among caregivers of relatives with mental illness in Singapore.

    abstract::Affiliated stigma often refers to internalized stigma among family members of stigmatized individuals. This study aimed to investigate the relationship between affiliate stigma and quality of life (QOL) among primary caregivers of individuals with mental illness undergoing treatment at the Institute of Mental Health, ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Zhang Y,Subramaniam M,Lee SP,Abdin E,Sagayadevan V,Jeyagurunathan A,Chang S,Shafie SB,Abdul Rahman RF,Vaingankar JA,Chong SA

    更新日期:2018-07-01 00:00:00

  • Association of adoptive child's thought disorders and schizophrenia spectrum disorders with their genetic liability for schizophrenia spectrum disorders, season of birth and parental Communication Deviance.

    abstract::Joint effects of genotype and the environment have turned out to be significant in the development of psychotic disorders. The purpose of the present study was to assess the association of an adoptive child׳s thought and schizophrenia spectrum disorders with genetic and environmental risk indicators and their interact...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Roisko R,Wahlberg KE,Hakko H,Tienari P

    更新日期:2015-04-30 00:00:00

  • Correlates of response to Olanzapine in a North Indian Schizophrenia sample.

    abstract::Olanzapine is widely used for the treatment of schizophrenia and is considered a first line medication in India. Along with other factors, the variation in response and side effects to this agent may be accounted for by genetic differences among patients. Olanzapine was administered for 6 weeks to Indian subjects with...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Thomas P,Srivastava V,Singh A,Mathur P,Nimgaonkar VL,Lerer B,Thelma BK,Deshpande SN

    更新日期:2008-12-15 00:00:00

  • CSF CRH in abstinent cocaine-dependent patients.

    abstract::Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determin...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Roy A,Bissette G,Williams R,Berman J,Gonzalez B

    更新日期:2003-03-25 00:00:00

  • Insecure attachment as a factor in hoarding behaviors in a non-clinical sample of women.

    abstract::Hoarding is linked to ambivalence and uncertainty about one's self and others. These notions are close to those constituting attachment representations. Hoarding is also linked to seeking support from objects. Studies concerning attachment and hoarding suggest that attachment representations may impact seeking or poss...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Danet M,Secouet D

    更新日期:2018-12-01 00:00:00

  • A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia.

    abstract::A meta-analysis study reported serum brain-derived neurotrophic factor (BDNF) levels as a potential biomarker for schizophrenia. However, at the time, commercially available human ELISA kits were unable to distinguish between pro-BDNF (precursor BDNF) and mature BDNF, because of limited antibody specificity. Here, we ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Niitsu T,Ishima T,Yoshida T,Hashimoto T,Matsuzawa D,Shirayama Y,Nakazato M,Shimizu E,Hashimoto K,Iyo M

    更新日期:2014-02-28 00:00:00

  • Age structure at diagnosis affects aggression in a psychiatric inpatient population: age structure affecting inpatient aggression.

    abstract::Study of inpatient aggression in psychiatric inpatient units (PIUs), where vulnerable patients interact intensely in small groups, is hampered by a lack of systematic monitoring of aggressive events in the context of group dynamics. Our current study examines the relationship between aggression and group structure in ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cho UJ,Lee J,Kim HW,Lee JS,Joo YH,Kim SY,Kim CY,Shin YW

    更新日期:2014-12-30 00:00:00

  • Association study of X chromosome SNPs in attempted suicide.

    abstract::We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10(-4)) and GRIA3 (P=4.01×10(-4)). These findings highlight the need for larger sample...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Jancic D,Seifuddin F,Zandi PP,Potash JB,Willour VL

    更新日期:2012-12-30 00:00:00

  • Cooperative versus competitive influences of emotion and cognition on decision making: A primer for psychiatry research.

    abstract::Clinical research across the developmental spectrum increasingly reveals the nuanced ways in which emotion and cognition can work to either support or derail rational (i.e., healthy or goal-consistent) decision making. However, psychological theories offer discrepant views on how these processes interact, and on wheth...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Chick CF

    更新日期:2019-03-01 00:00:00

  • Non-pharmacological interventions for preventing weight gain in patients with first episode schizophrenia or bipolar disorder: A systematic review.

    abstract::Weight gain is a side effect of antipsychotic medication and highly prevalent in people with schizophrenia or bipolar disorder, increasing their overall cardio-metabolic risk. We conducted a systematic review on non-pharmacological interventions for preventing/reducing weight gain or increase in waist-circumference in...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Nyboe L,Lemcke S,Møller AV,Stubbs B

    更新日期:2019-11-01 00:00:00

  • Magnetic resonance imaging in social phobia.

    abstract::Recent studies have implicated dopamine and the basal ganglia circuits in the pathophysiology of social phobia. Twenty-two patients who met DSM-III-R criteria for social phobia and 22 age- and sex-matched control subjects underwent magnetic resonance imaging (MRI). MRI was performed with a 1.5 Tesla General Electric S...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Potts NL,Davidson JR,Krishnan KR,Doraiswamy PM

    更新日期:1994-04-01 00:00:00

  • The association between alexithymia as assessed by the 20-item Toronto Alexithymia Scale and depression: A meta-analysis.

    abstract::Patients with depression exhibit high rates of alexithymia, representing a major public health concern. We sought to examine relationships between depression severity and alexithymia as assessed by the Toronto Alexithymia Scale (TAS-20) and the TAS-20 subscales of difficulty identifying feelings (DIF), difficulty desc...

    journal_title:Psychiatry research

    pub_type: 杂志文章,meta分析,评审


    authors: Li S,Zhang B,Guo Y,Zhang J

    更新日期:2015-05-30 00:00:00

  • Personality style differences in visual search performance.

    abstract::The present study continues the examination of the personality styles in normal populations that have been described in the clinical literature. Earlier work has focused on behavioral, attitudinal, and cognitive components of the personality styles. The present study extends our exploration of the cognitive domain by ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Magaro PA,Smith P,Ashbrook RM

    更新日期:1983-10-01 00:00:00

  • Visual event-related potentials as markers of hyperarousal in Gulf War illness: evidence against a stress-related etiology.

    abstract::An exaggerated response to emotional stimuli is among the many symptoms widely reported by veterans of the 1991 Persian Gulf War. These symptomologies have been attributed to damage and dysfunction associated with deployment-related exposures. We collected event-related potential data from 22 veterans meeting Haley cr...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Tillman GD,Calley CS,Green TA,Buhl VI,Biggs MM,Spence JS,Briggs RW,Haley RW,Kraut MA,Hart J Jr

    更新日期:2013-03-30 00:00:00

  • Desipramine subsensitizes nicotinic mechanism involved in regulating core temperature.

    abstract::Desipramine HCl, 10 mg/kg i.p. twice daily, produced subsensitivity to the hypothermic effects of nicotine, 1 mg/kg, after 1 and 2 weeks of treatment in male Sprague-Dawley rats, Phenelzine sulfate, fluoxetine HCl, and bright artificial light produced the same effect. The capacity of three chemically distinct classes ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Dilsauer SC,Hariharen M,Davidson RK

    更新日期:1988-07-01 00:00:00

  • Neural correlates of episodic and semantic memory retrieval in borderline personality disorder: an fMRI study.

    abstract::Verbal memory impairment in borderline personality disorder (BPD) is still a matter of debate. In this study we combine investigations of both, memory retrieval as well as underlying neural circuits in BPD. Functional magnetic resonance imaging (fMRI) was used to study regional brain activation in 18 right-handed fema...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Mensebach C,Beblo T,Driessen M,Wingenfeld K,Mertens M,Rullkoetter N,Lange W,Markowitsch HJ,Ollech I,Saveedra AS,Rau H,Woermann FG

    更新日期:2009-02-28 00:00:00

  • Exploration of dimensions of psychopathology in neuroleptic-naïve patients with recent-onset schizophrenia/schizophreniform disorder.

    abstract::Previous studies have suggested that schizophrenic psychopathology segregates into three orthogonal dimensions, viz., psychosis, negative and disorganization. Most of these reports were based on studies on medicated patients with varying degrees of chronicity. The present study aimed at exploring the dimensionality of...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: John JP,Khanna S,Thennarasu K,Reddy S

    更新日期:2003-11-01 00:00:00

  • Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients.

    abstract::Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrela...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lee HY,Kim YK

    更新日期:2010-01-30 00:00:00

  • Opposite effects of smoking and nicotine intake on cognition.

    abstract::Our main purpose was to investigate how smoking and nicotine interacted with specific aspects of cognitive functioning. The research was conducted in two parts: (i) an investigation of cognition in heavy smokers and healthy nonsmokers, and (ii) an investigation of cognition in healthy nonsmokers enrolled in a clinical...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Almeida NL,Rodrigues SJ,Gonçalves LM,Silverstein SM,Sousa IC,Gomes GH,Butler PD,Fernandes TP,Santos NA

    更新日期:2020-11-01 00:00:00

  • Blunted cardiovascular and catecholamine stress reactivity in women with bulimia nervosa.

    abstract::Cardiovascular and catecholamine responses to mental stressors were investigated in women with bulimia nervosa (BN) and in healthy control subjects. Fifteen women with BN and 15 control subjects completed psychosocial questionnaires before laboratory testing, where they were exposed to an interpersonally based speech ...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Koo-Loeb JH,Pedersen C,Girdler SS

    更新日期:1998-07-27 00:00:00

  • Effects of d-amphetamine on aggressive responding of normal male subjects.

    abstract::Male research subjects were administered placebo and three doses of d-amphetamine (5, 10, and 20 mg/70 kg of body weight) under double-blind conditions in a laboratory situation that provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by the presentati...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Cherek DR,Steinberg JL,Kelly TH,Robinson D

    更新日期:1987-07-01 00:00:00

  • Comparison of a standard psychiatric evaluation to rating scales and EEG in the differential diagnosis of attention-deficit/hyperactivity disorder.

    abstract::The objective was to investigate the effectiveness of rating scales and electroencephalography (EEG) in detecting the presence of attention-deficit/hyperactivity disorder (ADHD) within a diverse clinical sample. A standard psychiatric evaluation was used to assess 26 children/adolescents who presented to a clinic beca...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Quintana H,Snyder SM,Purnell W,Aponte C,Sita J

    更新日期:2007-08-30 00:00:00

  • Seasonal trends in depressive problems among United States children and adolescents: a representative population survey.

    abstract::This study examined season-of-assessment differences in parent and child reports of depressive problems on well-validated instruments in 2009 U.S. children and adolescents, aged 6 to 18 years, from a nationally representative population survey. A parent completed the Child Behavior Checklist (CBCL) for each participan...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Nillni YI,Rohan KJ,Rettew D,Achenbach TM

    更新日期:2009-12-30 00:00:00

  • The association between trauma and delusional-like experiences.

    abstract::Individuals exposed to childhood trauma are more likely to report delusional-like experiences (DLE). This study examined the association between trauma exposure and DLE in a large community sample, investigating different trauma types and age-at-first-exposure to trauma. Subjects were from the Australian National Surv...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Saha S,Varghese D,Slade T,Degenhardt L,Mills K,McGrath J,Scott J

    更新日期:2011-09-30 00:00:00

  • Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients.

    abstract::Depression is associated with a lowered degree of esterification of serum cholesterol, an increased C20:4omega6/C20:5omega3 ratio and decreases in omega3 fractions in fatty acids (FAs) or in the red blood cell membrane. The aims of the present study were to examine: (i) serum phospholipid and cholesteryl ester composi...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Maes M,Christophe A,Delanghe J,Altamura C,Neels H,Meltzer HY

    更新日期:1999-03-22 00:00:00