Abstract：
:Implementation science is focused on maximizing the adoption, appropriate use, and sustainability of effective clinical practices in real world clinical settings. Many implementation science questions can be feasibly answered by fully experimental designs, typically in the form of randomized controlled trials (RCTs). Implementation-focused RCTs, however, usually differ from traditional efficacy- or effectiveness-oriented RCTs on key parameters. Other implementation science questions are more suited to quasi-experimental designs, which are intended to estimate the effect of an intervention in the absence of randomization. These designs include pre-post designs with a non-equivalent control group, interrupted time series (ITS), and stepped wedges, the last of which require all participants to receive the intervention, but in a staggered fashion. In this article we review the use of experimental designs in implementation science, including recent methodological advances for implementation studies. We also review the use of quasi-experimental designs in implementation science, and discuss the strengths and weaknesses of these approaches. This article is therefore meant to be a practical guide for researchers who are interested in selecting the most appropriate study design to answer relevant implementation science questions, and thereby increase the rate at which effective clinical practices are adopted, spread, and sustained.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Miller CJ,Smith SN,Pugatch Mdoi
10.1016/j.psychres.2019.06.027subject
Has Abstractpub_date
2020-01-01 00:00:00pages
112452eissn
0165-1781issn
1872-7123pii
S0165-1781(19)30683-3journal_volume
283pub_type
杂志文章,评审abstract：:Magnetic resonance (MR) imaging now allows the qualitative and quantitative assessment of the human brain in vivo. As MR imaging resolution has improved, precise measurement of small brain structures has become possible. Methods of measuring brain regions from MR images include both manual and semiautomated methods. D...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(96)02790-4
更新日期：1996-10-07 00:00:00
abstract：:This report describes a computer program for applying a new statistical method for determining levels of agreement, or reliability, when multiple examiners evaluate a single subject. The statistics that are performed include the following: an overall level of agreement, expressed as a percentage, that takes into accou...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(97)00093-0
更新日期：1997-08-29 00:00:00
abstract：:Alterations in secretion of stress hormones within the hypothalamic-pituitary-adrenal (HPA) axis have repeatedly been found in substance-related addictive disorders. It has been suggested that glucocorticoids might contribute to the development and maintenance of substance use disorders by facilitatory effects on beha...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.078
更新日期：2015-03-30 00:00:00
abstract：:The association of seven GDNF tag SNPs with depression, heroin dependence (HD) and schizophrenia was evaluated in Chinese. An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD. ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.08.025
更新日期：2013-12-30 00:00:00
abstract：:Pathological gamblers (PGs) perform differently on neurocognitive tests than do healthy controls (HC). The aim of this study was to assess "waiting ability" - a major components of inhibition control-using a modified Stop Signal Task (SST) in a population of male PGs (N=55), and HCs (N=53). Results indicated no differ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.038
更新日期：2015-12-15 00:00:00
abstract：:The study aims to establish the concordant validity of the Early Detection Primary Care Checklist (PCCL); a 20 item tool designed to help primary care practitioners identify young people in the early stages of psychosis. The checklist was completed by the referring practitioners of 176 young people referred to early d...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.07.040
更新日期：2012-12-30 00:00:00
abstract：:Disturbances in the hippocampal glutamate (Glu)/N-methyl-d-aspartate (NMDA) system have been implicated in the pathophysiology of bipolar disorder (BD). Here we aim to provide a targeted integration of two measures of glutamatergic functioning in BD; the association between mismatch negativity (MMN) and in vivo hippoc...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.05.002
更新日期：2015-08-30 00:00:00
abstract：:Absence of the adhesio interthalamica (AI) in schizophrenic first episode patients is suggestive for another marker of early developmental neuropathologic changes. Moreover, findings suggest that schizophrenic patients without AI are characterised by more severe negative symptoms. The study aims to investigate the pre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(02)00044-6
更新日期：2002-10-01 00:00:00
abstract：:Understanding what happens at first onset of auditory verbal hallucinations (AVHs) is extremely important on a clinical and theoretical level. Previous studies have only focused on age with regard to first onset of AVHs. In the current epidemiological study, we examined a number of aspects relating to first onset of A...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.060
更新日期：2018-03-01 00:00:00
abstract：:Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.08.029
更新日期：2011-03-30 00:00:00
abstract：:A woman complained of feeling a "metal-like thing" in her oral cavity 4 years after a stroke. She was convinced of the physical nature of her complaint despite intact dental and neurological findings. Somatosensory evoked magnetic fields suggested that her decreased right SII function was compensated for by the right ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.10.003
更新日期：2006-01-30 00:00:00
abstract：:Depression is a common illness which tends to have a relapsing progression. Revealing vulnerability factors is an important step towards improved treatment and prevention. Previous studies of individuals in remission indicate that inhibitory control is more strongly impaired than other cognitive functions. Studies hav...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.038
更新日期：2016-01-30 00:00:00
abstract：:This study aimed to identify how frequently suicidal individuals disclosed their ideation, assess which sources were perceived to be most helpful and identify correlates of disclosure and source helpfulness. A cross-sectional survey was conducted with 1,616 Australian adults reporting suicidal ideation in the past 12-...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.05.024
更新日期：2019-08-01 00:00:00
abstract：:One inhalation of 35% CO2 in oxygen was administered to 36 patients with anxiety disorders and 14 healthy controls. Eighteen patients had a diagnosis of panic disorder (PD) and 18 of obsessive-compulsive disorder (OCD). As a placebo control for CO2, compressed air was administered in a double-blind design. Immediately...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90121-k
更新日期：1990-02-01 00:00:00
abstract：:The promotion and maintenance of mental health is an increasingly important societal issue. Previous research has shown that identification with social groups is positively associated with adult mental wellbeing, with multiple group identifications being particularly beneficial. The aim of the current study was to inv...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.088
更新日期：2015-08-30 00:00:00
abstract：:To date, there has been limited investigation identifying predictors of deliberate self-harm (DSH) among sexual minority adults. The present study examined the likelihood of DSH by sexual minority status as measured by self-reported sexual identity and sexual attraction in the National Epidemiologic Survey on Alcohol ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112863
更新日期：2020-02-10 00:00:00
abstract：:Many studies have demonstrated that depression is associated with a worse cardiovascular outcome and increased risk of death in those experiencing an acute coronary syndrome (ACS). Recent studies have suggested, however, that any association is strongly influenced by the timing of the depression, with post-ACS depress...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.07.015
更新日期：2011-02-28 00:00:00
abstract：:It has been suggested that low frequency transcranial magnetic stimulation (TMS) over left temporo-parietal cortex may reduce the frequency and intensity of auditory hallucinations in schizophrenia. Sixteen patients with hallucinations, treatment-resistant for at least 2 months, were randomised into a placebo-controll...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.psychres.2004.03.005
更新日期：2004-06-30 00:00:00
abstract：:There is a paucity of research on determinants associated with changes in perceived met needs for care over time. This study used a longitudinal cohort to explore changes in percentages of perceived met needs over time and to identify its related determinants. Data analyzed was from a longitudinal community-based surv...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.08.117
更新日期：2018-11-01 00:00:00
abstract：:A study of weight change in subjects treated with imipramine was performed on recurrent depressive outpatients. The patients (n = 52) were treated with imipramine (200-250 mg/day) and psychotherapy for 16 weeks. Each individual was weighed upon entry to the study (drug-free) and then weekly thereafter for 16 weeks. Of...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(86)90074-0
更新日期：1986-04-01 00:00:00
abstract：:Proton magnetic resonance spectroscopy ((1)H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use (1)H MRS to assess ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.01.010
更新日期：2006-06-30 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) and social anxiety disorder (SAD) are highly comorbid (Collimore et al., 2010). Trauma may present a shared environmental factor contributing to the development of comorbidity; however, existent research has been hampered by use of restrictive samples and limitations in the range o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.10.036
更新日期：2016-12-30 00:00:00
abstract：:Although many studies have attempted to determine whether early object loss influences the risk of developing major affective illness in adulthood, there are few empirical data relating early loss to subsequent hypothalamic-pituitary-adrenal (HPA) axis dysfunction in adulthood. Forty-five psychiatric inpatients admitt...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90026-y
更新日期：1992-12-01 00:00:00
abstract：:This study assessed the subjective and cardiovascular effects of relevant doses of cocaine administration during steady-state treatment of the combination of amantadine and baclofen compared to placebo. Participants included 8 healthy, male, cocaine-dependent, non-treatment-seeking individuals (age=36.6+/-5.9; 75% Afr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.03.012
更新日期：2007-08-30 00:00:00
abstract：:Lithium is an effective prophylactic agent in mood disorders, and genetic factors are likely to modulate individual susceptibility to lithium treatment. The aim of this study is to investigate the influence of dopamine receptor D2 (DRD2), D4 exon 3 (DRD4), and gamma-aminobutyric acid type A (GABA(A)) receptor alpha-1 ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(99)00056-6
更新日期：1999-07-30 00:00:00
abstract：:The orexigenic hormone ghrelin is involved in the regulation of food intake and energy balance. Previous findings suggest its involvement in the modulation of mesolimbic reward pathways, thus potentially being relevant in the pathophysiology of substance use disorders such as alcohol dependence. In the present study, ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2018.12.095
更新日期：2019-02-01 00:00:00
abstract：:There is a strong link between personality disorders (PDs) and aggression. This is reflected in high prevalence rates of PD diagnoses in forensic samples, and in several diagnostic criteria of PDs directly referring to elevated levels of aggression. Aggression can stem from two distinct types of motivation; reactive o...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2015.07.052
更新日期：2015-09-30 00:00:00
abstract：:N-Acetyl-aspartate (NAA), a marker of neuronal integrity, has been found to be reduced in frontal regions in schizophrenia. However, the impact of antipsychotic drug type on NAA has not been carefully evaluated. We studied outpatients with schizophrenia/schizoaffective disorders chronically treated with haloperidol or...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(01)00102-0
更新日期：2001-10-01 00:00:00
abstract：:To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.03.015
更新日期：2015-06-30 00:00:00
abstract：:Moclobemide is a reversible, short-acting monoamine oxidase inhibitor (MAO1), specific for MAO A. To study moclobemide effects on the tyramine pressor response, we gave 12 depressed patients (2 males, 10 females; mean age 47, SD 11 years) an i.v. tyramine test after 7 days drug free. The mean (+/- SD) tyramine dose to...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(87)90036-9
更新日期：1987-11-01 00:00:00
