Abstract：
:Alterations in secretion of stress hormones within the hypothalamic-pituitary-adrenal (HPA) axis have repeatedly been found in substance-related addictive disorders. It has been suggested that glucocorticoids might contribute to the development and maintenance of substance use disorders by facilitatory effects on behavioral responses to substances of abuse. The objective of this pilot study was to investigate HPA axis activity in patients with non-substance-related addictive disorders, i.e. pathological gambling and internet use disorder. We measured plasma levels of copeptin, a vasopressin surrogate marker, adrenocorticotropic hormone (ACTH) and cortisol in male patients with pathological gambling (n=14), internet use disorder (n=11) and matched healthy controls for pathological gambling (n=13) and internet use disorder (n=10). Plasma levels of copeptin, ACTH and cortisol in patients with pathological gambling or internet use disorder did not differ among groups. However, cortisol plasma levels correlated negatively with the severity of pathological gambling as measured by the PG-YBOCS. Together with our findings of increased serum levels of brain-derived neurotrophic factor (BDNF) in pathological gambling but not internet use disorder, these results suggest that the pathophysiology of pathological gambling shares some characteristics with substance-related addictive disorders on a neuroendocrinological level, whereas those similarities could not be observed in internet use disorder.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Geisel O,Panneck P,Hellweg R,Wiedemann K,Müller CAdoi
10.1016/j.psychres.2014.11.078subject
Has Abstractpub_date
2015-03-30 00:00:00pages
97-102issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(14)01005-1journal_volume
226pub_type
杂志文章abstract：:Age disorientation was studied in 45 geriatric patients with chronic mood disorders. In a yearly assessment of cognitive functions, subjects were questioned about their age, year of birth, and the current year. Patients who misstated their age by > or = 5 years were considered age disoriented. Among the 45 patients, a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02853-6
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abstract：:Posttraumatic stress disorder (PTSD) research has focused largely on fear processing. However, interpersonal trauma exposure can also impact interpersonal functioning and the perception of the trustworthiness of others. The present study examined facial perceptions of fearfulness and trustworthiness in individuals wit...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.056
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pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2015.11.045
更新日期：2016-01-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.05.004
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(98)00015-8
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.07.019
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.09.039
更新日期：2018-04-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.07.003
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journal_title：Psychiatry research
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更新日期：2004-04-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(96)02790-4
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pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.037
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112634
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.08.026
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pub_type： 杂志文章
doi：10.1016/j.psychres.2011.03.015
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.02.006
更新日期：2009-04-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.074
更新日期：2019-01-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.06.001
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journal_title：Psychiatry research
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doi：10.1016/0165-1781(94)90035-3
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.001
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.056
更新日期：2014-09-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90002-m
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.01.002
更新日期：2009-12-30 00:00:00
abstract：:The dopamine hypothesis of schizophrenia received strong support when a two- to three-fold elevation of D2 receptor densities was demonstrated by positron emission tomography (PET) and [11C]N-methylspiperone ([11C]NMSP). In the present study, the reproducibility of this finding was examined by application of a similar...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(95)02732-d
更新日期：1995-08-08 00:00:00
