Abstract：
:The anterior cingulate is a key component of neural networks subserving attention and emotion regulation, functions often impaired in patients with psychosis. The study aimed to examine anterior cingulate volumes and sulcal morphology in a group of patients with childhood-onset schizophrenia (COS) compared with controls. Brain magnetic resonance imaging (MRI) scans were obtained in 13 COS and 18 matched control children, ages 6-17 years. Volume measures for the anterior cingulate gyrus (ACG) were obtained through manual labeling. A determination of cingulate sulcal pattern (single or double) was made for each hemisphere. The COS group had a reduced leftward skew of the double cingulate sulcal pattern, and absence of the normal left>right ACG volume asymmetry. The right ACG was larger in the COS than in controls. The schizophrenic children showed decreases in all ACG volumes with age, while the controls showed increases or no change. The data suggest that significant cingulate abnormalities may result from deviations in progressive neurodevelopmental processes, beginning before birth and continuing through childhood and adolescence, in persons who develop schizophrenia. These structural differences may relate to the well-described cognitive deficits these children display, and to the cardinal symptoms of schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Marquardt RK,Levitt JG,Blanton RE,Caplan R,Asarnow R,Siddarth P,Fadale D,McCracken JT,Toga AWdoi
10.1016/j.pscychresns.2005.01.001subject
Has Abstractpub_date
2005-04-30 00:00:00pages
221-33issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(05)00003-Xjournal_volume
138pub_type
杂志文章abstract：:Major depression (MD) is a common psychiatric disorder and one of its most serious symptoms is suicidal ideation. Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.12.006
更新日期：2009-12-30 00:00:00
abstract：:Association Splitting, a novel cognitive intervention, was tested in patients with alcohol dependence as an add-on intervention in an initial randomized controlled trial. Preliminary support for Association Splitting has been found in patients with obsessive-compulsive disorder, as well as in an online pilot study of ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2016.02.051
更新日期：2016-04-30 00:00:00
abstract：:Schizophrenia (n=68) and control (n=62) participants matched on cigarette smoking history were assessed on executive function, decision-making and impulsivity tasks. In controls, executive function and decision-making correlated positively with each other and negatively with impulsivity. There were no inter-task corre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.08.022
更新日期：2013-01-30 00:00:00
abstract：:The experience of maternal distress in pregnancy is often linked with poorer obstetric outcomes for women as well as adverse outcomes for offspring. Alterations in placental glucocorticoid signalling and subsequent increased fetal exposure to cortisol have been suggested to underlie this relationship. In the current s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.05.013
更新日期：2017-09-01 00:00:00
abstract：:Previous research suggests that trauma may contribute to psychosis onset. In this study, we examine the effect of parental loss of a child on the onset of psychotic experience using data from the National Comorbidity Survey Replication, hypothesizing that child loss will precede the onset of psychosis and will be asso...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.08.008
更新日期：2013-01-30 00:00:00
abstract：:Social anhedonia is a promising indicator for the vulnerability towards developing schizophrenia-spectrum disorders and is an important determinant of the social impairment associated with these disorders. It is unknown if social anhedonia is associated with true deficits in experiential reactions or if lower social f...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.07.050
更新日期：2012-12-30 00:00:00
abstract：:Patients with psychosis have been found to suffer from physical illnesses more commonly than the general population. In this report, self-reported physical ill health and its correlates among subjects with and without vulnerability to psychosis in a sample of first-degree relatives, help-seekers and controls were inve...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.03.016
更新日期：2007-04-15 00:00:00
abstract：:Kynurenine pathway (KP) activation is associated with many neuropsychiatric diseases, such as major depressive disorder (MDD) and Alzheimer's disease (AD). Investigations conducted on MDD seldom shed light on KP changes in late-life depression (LLD), though memory deficit (MD) in patients with LLD is a predictable sig...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.08.041
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To examine the prevalence of disordered eating behaviors among adolescents and adults living in the same household. METHODS:We conducted a population-based cross-sectional study developed with a probabilistic sample of 511 adolescents and 1254 adults living in the metropolitan area of Rio de Janeiro, Brazil....
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.021
更新日期：2013-12-15 00:00:00
abstract：:Mindfulness-based strategies show promise for targeting the construct of impulsivity and associated variables among problematic alcohol users. This study examined the moderating role of intervention (mindfulness vs relaxation vs control) on trait impulsivity and three outcomes examined post-intervention (negative affe...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.04.115
更新日期：2016-08-30 00:00:00
abstract：:Depressive disorders are common, heterogeneous conditions involving physical and psychological symptoms, and substantial impairment in quality of life (QoL). However, relationships between depressive symptoms and QoL are poorly understood, and little research has directly compared relationships between subtypes of dep...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113049
更新日期：2020-07-01 00:00:00
abstract：:Although brain lactate levels are typically low and difficult to measure, a few previous investigators have reported that brain lactate levels are elevated in patients with bipolar disorder. The present study investigated the distribution of lactate in bipolar and healthy brains using 2D proton magnetic resonance spec...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.03.004
更新日期：2013-09-30 00:00:00
abstract：:Two groups of 32 rats were challenged in a well-habituated environment with haloperidol (0.5 mg/kg), haloperidol (0.1 mg/kg), domperidone (0.1 mg/kg), or saline to study the effect of these drugs on defecation--an index of emotionality--and voluntary movements in the 2 hours after the injection. The haloperidol-treate...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90053-j
更新日期：1993-04-01 00:00:00
abstract：:This 5-week, randomized, double-blind, placebo-controlled trial investigated the efficacy and tolerability of high frequency repetitive transcranial magnetic stimulation (rTMS) directed to the left prefrontal cortex in drug-resistant depressed patients. Fifty-four patients were randomly assigned to receive 10 daily ap...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2005.06.008
更新日期：2005-11-15 00:00:00
abstract：:The Cocaine Craving Questionnaire was administered to 205 cocaine addicts. A 6/5 cut-off corresponded to the scale's best performance. Reliability was 0.803. Receiver Operating Characteristic analysis resulted in an area under the curve of 0.7199 +/- 0.0384, and dimensionality resulted in a three-factor solution. The ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.01.010
更新日期：2006-06-15 00:00:00
abstract：:No differences in levels of type A monoamine oxidase (MAO) were observed in cultured human skin fibroblasts from nine patients with bipolar depressive illness as compared to 18 age-, sex-, and race-matched controls. All cells were biopsied and cultured under parallel conditions. Fibroblasts from monozygotic twins (thr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(80)90022-0
更新日期：1980-07-01 00:00:00
abstract：:The interplay between Callous Unemotional Traits (CU) and Moral Disengagement (MD) was examined in a sample of 90 adolescents with Disruptive Behavior Disorders. Using a person-centered approach, three CU and MD configurations were identified, attesting the strong relationship between these two moral dimensions. Howev...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.043
更新日期：2017-12-01 00:00:00
abstract：:Some patients with autoimmune disease have an elevation of the B lymphocyte population bearing the CD5 marker. In an attempt to replicate an earlier report of elevated CD5+ B cells in schizophrenic patients, lymphocytes were phenotyped in 116 patients with schizophrenia and 166 control subjects. The CD5+ B lymphocyte ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90114-v
更新日期：1993-07-01 00:00:00
abstract：:Neurobiological mechanisms underlying the development of major depressive disorder (MDD) may differ depending on age-of-onset. Our aim was to compare patients who differ in age-of-onset, while controlling for illness duration, and number of depressive episodes. By directly comparing early-(EOD) and late-onset (LOD) pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.09.003
更新日期：2013-12-30 00:00:00
abstract：:This study tests the hypothesis that adolescents with major depression exhibit abnormalities in cerebral asymmetry previously found among adults. Perceptual asymmetry was assessed through tests of verbal and non-verbal dichotic listening in four groups - 48 adolescents with major depression, 22 adolescent comparisons ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00101-3
更新日期：2000-03-06 00:00:00
abstract：:The current study aimed to prove the antidepressant-like effects and the probable mechanisms of Schisandrin on depression, which induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, as indicated by the significant decrease in sucrose consumption...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.07.081
更新日期：2017-11-01 00:00:00
abstract：:Several studies have shown that schizophrenia is characterized by impaired frontal lobe functions, functions that are responsible, for example, for the management of rules, strategic reasoning, and selective attention. Using event-related potentials (ERP), we assessed the brain's electrical activity in a group of pati...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2003.05.001
更新日期：2005-03-30 00:00:00
abstract：:Social cognition is impaired in schizophrenia, is relatively independent of purely neurocognitive domains such as attention and executive functioning, and may be the strongest predictor of functional outcome in this disease. Within a motivated reasoning framework, we tested the hypothesis that the anti-inflammatory Th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.02.030
更新日期：2017-05-01 00:00:00
abstract：:Patients with borderline personality disorder (BPD) suffer from various impairments in emotional functioning such as affective instability, inappropriate anger and unstable relationships. These deficits may influence two fundamental motivational systems, the behavioral inhibition system (BIS) and behavioral activation...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.027
更新日期：2014-08-15 00:00:00
abstract：:We present psychometric properties and normative data by gender and educational level in scales related to schizotypy and affective disorders in a large population-based adult sample. As part of the 31-year follow-up survey of the Northern Finland 1966 Birth Cohort; Bipolar II scale (BIP2), Hypomanic Personality Scale...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.07.022
更新日期：2010-07-30 00:00:00
abstract：:Chronic stress can result in frequent or persistent challenges of the hypothalamic-pituitary-adrenal (HPA) axis resulting in abnormal cortisol patterns and increased risk for cardiovascular disease (CVD). Police work is an environment replete with stress. The present article describes associations between cortisol, a ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.06.012
更新日期：2009-08-30 00:00:00
abstract：:The aim of this study is to analyze whether clozapine serum concentration may affect fasting serum levels of several appetite regulating peptides: CART, PYY(1-36), NPY, AgRP, des-acylated ghrelin, leptin and obestatin. Serum concentration of clozapine and fasting serum levels of des-acylated ghrelin, neuropeptide Y (N...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.018
更新日期：2018-02-01 00:00:00
abstract：:Evidence on mental illness stigma abounds yet little is known about public perceptions of intellectual disability. This study examined causal beliefs about intellectual disability and schizophrenia and how these relate to awareness of the condition and social distance. UK lay people aged 16+(N=1752), in response to vi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.019
更新日期：2016-09-30 00:00:00
abstract：:Disruptive behavior disorders (DBD) are among the most commonly diagnosed mental disorders in children and adolescents. Some important characteristics of DBD vary based on the presence or absence of comorbid attention-deficit/hyperactivity disorder (ADHD), which may affect the understanding of and treatment decision-m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.01.005
更新日期：2012-06-30 00:00:00
abstract：:Depression is associated with cognitive impairment and suicidality. The independent association between cognitive impairment and suicidality is less clear. We examined the relationship between suicidal ideation and cognitive impairment in a sample of 50 veterans with depressive disorder diagnoses. Using zero-inflated ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112833
更新日期：2020-01-30 00:00:00
