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Transcranial magnetic stimulation in treatment-resistant depressed patients: a double-blind, placebo-controlled trial.

Abstract：

:This 5-week, randomized, double-blind, placebo-controlled trial investigated the efficacy and tolerability of high frequency repetitive transcranial magnetic stimulation (rTMS) directed to the left prefrontal cortex in drug-resistant depressed patients. Fifty-four patients were randomly assigned to receive 10 daily applications of either real or sham rTMS. Subjects assigned to receive active stimulation were divided into two further subgroups according to the intensity of stimulation: 80% vs. 100% of motor threshold (MT). At study completion, the response rates were 61.1% (n=11), 27.8% (n=5) and 6.2% (n=1) for the 100% MT group, 80% MT group and sham group, respectively. A significant difference (Pearson chi(2) test) was found between the 100% MT and sham groups, while the 80% MT group did not differ significantly from the sham group. Between the two active groups, a marginally significant difference was observed. Analysis of variance with repeated measures on Hamilton Depression Rating Scale scores revealed a significantly different decrease over time of depressive symptomatology among the three treatment groups. Treatment response appeared to be unrelated to the demographic and clinical characteristics recorded, and on the whole the technique was well tolerated. The results of this double-blind trial showed that rTMS may be a useful and safe adjunctive treatment for drug-resistant depressed patients.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Rossini D,Lucca A,Zanardi R,Magri L,Smeraldi E

doi

10.1016/j.psychres.2005.06.008

subject

Has Abstract

pub_date

2005-11-15 00:00:00

pages

1-10

issue

1-2

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(05)00200-3

journal_volume

137

pub_type

杂志文章,随机对照试验

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