CD5 positive B lymphocytes in schizophrenia: no alteration in numbers or percentage as compared with control subjects.

Abstract:

:Some patients with autoimmune disease have an elevation of the B lymphocyte population bearing the CD5 marker. In an attempt to replicate an earlier report of elevated CD5+ B cells in schizophrenic patients, lymphocytes were phenotyped in 116 patients with schizophrenia and 166 control subjects. The CD5+ B lymphocyte population was not elevated in medicated or never-medicated patients as compared with control subjects of similar age, race, gender, or social class. CD5+ B cells were also not elevated in patients who had circulating autoantibodies. The CD5+ B lymphocyte population was significantly elevated in African-American control subjects and patients in comparison with that in Caucasian control subjects and patients. Thus, although other immune alterations characterized a subset of patients with schizophrenia, an elevation of the CD5+ B lymphocyte population was not found in this study.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Ganguli R,Rabin BS

doi

10.1016/0165-1781(93)90114-v

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

69-78

issue

1

eissn

0165-1781

issn

1872-7123

pii

0165-1781(93)90114-V

journal_volume

48

pub_type

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