Identifying delirious states and autonomic cardiovascular dysfunction associated with amitriptyline treatment by standardized analysis of heart rate.

Abstract:

:Ninety-one patients treated with amitriptyline and 60 normal control subjects underwent a standardized heart rate analysis in supine posture. Tests included the determination of time- and frequency-derived measurements of heart rate variability. The patients differed significantly from the control subjects in all parameters investigated. Two-thirds of the patients treated with a tricyclic antidepressant (TCA) reached values that met the criteria for cardiovascular autonomic neuropathy. Our results provide evidence that heart rate analysis might be a more sensitive tool in diagnosing amitriptyline-associated anticholinergic delirium than determination of TCA plasma levels. Further research is needed to elucidate what implications the TCA-associated alteration of autonomic cardiovascular function might have for patients.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Rechlin T,Weis M,Claus D,Kaschka WP

doi

10.1016/0165-1781(95)02511-t

subject

Has Abstract

pub_date

1995-04-28 00:00:00

pages

279-87

issue

3

eissn

0165-1781

issn

1872-7123

pii

0165-1781(95)02511-T

journal_volume

56

pub_type

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