Abstract：
:The 2-deoxyglucose (2-DG) method was used to study regional metabolic changes in rats following chronic d-amphetamine treatment without subsequent challenges. Four groups of rats were pretreated (intraperitoneal administration) with d-amphetamine (0, 1, 5, or 10 mg/kg) once per day for 14 days. After a 7-day abstinence period without further challenge, the 2-DG method was used to measure the rates of local cerebral glucose utilization (LCGU). Significant metabolic changes among the four groups were found in five brain regions, including the nucleus accumbens and the lateral habenular nucleus. Another four groups of rats with the same pretreatment regimens, challenged with 5 mg/kg d-amphetamine, were used for behavioral testing. The results showed intense stereotyped behaviors in the 5 mg/kg and the 10 mg/kg groups. In the steady state, however, there were no significant glucose utilization changes in the nigrostriatal system, which is thought to be related to stereotyped behaviors. During steady state, metabolic changes were found in a limited number of brain regions. No difference in LCGU was found in the sensitization-related regions. Further challenges with stimulants may be necessary to investigate the metabolic responses after sensitization.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Tsai SJ,Huang YH,Chang LS,Yang YC,Sim CBdoi
10.1016/0165-1781(95)02496-jsubject
Has Abstractpub_date
1995-06-29 00:00:00pages
65-73issue
1eissn
0165-1781issn
1872-7123pii
016517819502496Jjournal_volume
57pub_type
杂志文章abstract：:Depressed mood is prevalent among individuals with schizophrenia, leading to difficulties in functioning. Typically, depressed mood is evaluated using retrospective assessments during which individuals are asked to recall their mood during the past week or month. However, as individuals with schizophrenia may display ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.03.008
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(86)90124-1
更新日期：1986-12-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,评审
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更新日期：2015-09-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.05.041
更新日期：2017-09-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.02.025
更新日期：2019-04-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.04.012
更新日期：2008-05-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.10.001
更新日期：2008-02-28 00:00:00
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journal_title：Psychiatry research
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更新日期：2020-12-24 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.05.007
更新日期：2011-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(92)90093-i
更新日期：1982-10-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(96)02839-9
更新日期：1996-11-25 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.06.009
更新日期：2012-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90164-3
更新日期：1988-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.03.030
更新日期：2019-05-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.08.004
更新日期：2011-01-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.11.026
更新日期：2013-04-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00344-4
更新日期：2001-12-31 00:00:00
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journal_title：Psychiatry research
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doi：10.1016/j.psychres.2019.112508
更新日期：2019-10-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.037
更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.07.003
更新日期：2004-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00282-7
更新日期：2001-09-20 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.11.012
更新日期：2014-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2014-08-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
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更新日期：2019-02-01 00:00:00
abstract：:Eating disorders (EDs) are psychiatric disorders associated with high morbidity and mortality. It is well established that patients with anorexia nervosa (AN) have an increased risk of premature death, whereas mortality data are lacking for the other EDs. This study aimed to establish mortality rates in a sample of ED...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.08.032
更新日期：2015-12-15 00:00:00
