Abstract：
:Studies which showed anticipation in families with schizophrenia suggested that a trinucleotide repeat expansion mechanism may be involved in the pathogenesis of familial schizophrenia. Furthermore, some studies involving the repeat expansion detection (RED) method showed the median length of CAG repeats to be longer in probands with schizophrenia than that in control subjects. We screened for a possible expanded CAG repeat by means of the direct identification of repeat expansion and cloning technique in 23 subjects (affected, 14; unaffected, 9) from six families with schizophrenia which showed anticipation. The polymorphism of a long and unstable CAG/CTG trinucleotide repeat, Dir1, was studied by PCR. No unusual expanded CAG/CTG trinucleotide repeat was detected in the subjects with familial schizophrenia. There was no significant difference between the affected and unaffected subjects in the allele frequency of Dir1. Our results suggest that a CAG expansion is not the mechanism underlying familial schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Ohara1 K,Ikeuchi T,Suzuki Y,Ohtani M,Ohara K,Tsuji Sdoi
10.1016/s0165-1781(00)00156-6subject
Has Abstractpub_date
2000-07-17 00:00:00pages
257-62issue
3eissn
0165-1781issn
1872-7123pii
S0165178100001566journal_volume
94pub_type
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