Abstract：
:Serum neuroleptic levels, prolactin levels, and clinical state were assessed for 1 year in 29 schizophrenic outpatients whose clinically determined neuroleptic dose had been reduced by 50%. Fifty-five percent of the subjects remained stable. Neuroleptic dose did not differ between relapsed and stable patients. Serum prolactin (PRL) assessed 2 weeks after dose reduction and mean PRL after reduction were significantly lower among relapsers. Serum neuroleptic levels were significantly lower for relapsers in patients on haloperidol. Among relapsers, there were no serum PRL or neuroleptic level differences between stable periods and the relapse episode. Among patients with relatively low neuroleptic bioavailability, relapsers reported lower levels of social activity and had social networks that were less enjoyable, more aversive, and less helpful than those of stable patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Faraone SV,Curran JP,Laughren T,Faltus F,Johnston R,Brown WAdoi
10.1016/0165-1781(86)90124-1subject
Has Abstractpub_date
1986-12-01 00:00:00pages
311-22issue
4eissn
0165-1781issn
1872-7123pii
0165-1781(86)90124-1journal_volume
19pub_type
杂志文章abstract：:As a psychiatric treatment, modern electroconvulsive therapy (ECT) requires anesthesia to enhance safety, but anesthetics may weaken its efficacy. Previous studies have provided inconsistent results and lack satisfactory details of the influence of anesthetics on ECT efficacy, which partially complicates the clinical ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.09.010
更新日期：2012-07-30 00:00:00
abstract：:In this study, we investigated whether polymorphisms of the dopamine D4 receptor (DRD4) gene were associated with psychotic symptomatology rather than with a unique diagnosis such as schizophrenia. A number of association studies between the DRD4 gene 48 bp-VNTR polymorphism at exon 3 and psychotic disorders have been...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.12.011
更新日期：2007-12-03 00:00:00
abstract：:Bipolar disorder (BD) adversely affects daily activities/functioning. The Sheehan Disability Scale (SDS) assesses disability in work/school activities, family relationships, and social functioning, and it evaluates the functional impact of psychiatric disorders. BD outpatients from 21 U.S. sites completed a battery of...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.11.018
更新日期：2009-01-30 00:00:00
abstract：:This study evaluated visual perceptual grouping in schizophrenia to test the hypothesis that the disorganization syndrome in schizophrenia is related to a deficit in cognitive coordination. Perceptual grouping was examined with three psychophysically well-controlled tasks in patients with disorganized schizophrenia (n...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.10.016
更新日期：2006-12-07 00:00:00
abstract：:Recognition and treatment of comorbid chronic psychotic symptoms in post-traumatic stress disorder (PTSD) has become of increasing clinical interest. Altered dopamine beta-hydroxylase (DBH) activity has been reported in mood disorders. Plasma DBH is reduced in major depression with psychosis and elevated in bipolar di...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(98)00002-x
更新日期：1998-02-27 00:00:00
abstract：:The aim of this study is to investigate whether mismatch negativity (MMN) is associated with functional status or is a state-independent trait for schizophrenia. We assessed MMN in 26 patients with schizophrenia, 20 healthy subjects with high genetic loading, and 48 healthy controls. Repeated measures analysis of vari...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.02.012
更新日期：2014-04-30 00:00:00
abstract：:A variable number of tandem repeats (VNTR) in the second intron of the serotonin transporter gene (STin2) has been studied in association with the susceptibility to affective disorders. Recently, it was reported that selective serotonin reuptake inhibitors were more effective in patients with major depressive disorder...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(02)00141-5
更新日期：2002-08-30 00:00:00
abstract：:While research using Experience Sampling Methodology (ESM) suggests that, in general, contact with relatives or friends may be protective for psychotic experiences, contact with high-Expressed Emotion (high-EE) relatives can have adverse consequences for patients. This study investigated whether contact with high-EE r...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.060
更新日期：2016-11-30 00:00:00
abstract：:This study examined the degree to which subclinical obsessive-compulsive symptoms (SOCS) among individuals with Attention Deficit/Hyperactivity Disorder (AD/HD) were associated with response inhibition difficulties on a performance-based test. Participants consisted of 64 adults with AD/HD who completed the Conner׳s C...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.01.034
更新日期：2014-04-30 00:00:00
abstract：:Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.08.029
更新日期：2011-03-30 00:00:00
abstract：:Sparse evidence of a co-aggregation of the risk of schizophrenia and bipolar disorder provides support for a shared but nonspecific genetic etiology of bipolar disorder and schizophrenia. Temperaments are conceptualized as trait sub-syndromic conditions of major pathologies. This study set out to test the hypothesis o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.10.027
更新日期：2015-01-30 00:00:00
abstract：:Several neurophysiological indicators of abnormal sensory processing found in psychosis are also found in lower incidence in normal populations, particularly those at the age of risk for illness. One such parameter, gating of the auditory evoked potential, was evaluated in college students. Auditory stimuli were prese...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(86)90102-2
更新日期：1986-11-01 00:00:00
abstract：:Since abnormalities in distal upper limb development are among the minor physical anomalies associated with schizophrenia we attempted to determine whether patients with schizophrenia can be identified on the basis of specific morphologic and dermatoglyphic features of the hand. Photographs and prints of the hands of ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.08.026
更新日期：2013-12-30 00:00:00
abstract：:Evidence on mental illness stigma abounds yet little is known about public perceptions of intellectual disability. This study examined causal beliefs about intellectual disability and schizophrenia and how these relate to awareness of the condition and social distance. UK lay people aged 16+(N=1752), in response to vi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.019
更新日期：2016-09-30 00:00:00
abstract：:The present study introduces a novel measure of adenosine receptor sensitivity that is based on the action of specific receptor blockers (e.g., caffeine) to potentiate the ability to detect threshold quinine concentrations. The test is used to compare gustatory adenosinergic responses to caffeine challenges in normal ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90014-0
更新日期：1989-12-01 00:00:00
abstract：:This study examines the relationships between explicit and implicit self-esteem and self-referent memory biases in depression. We specifically tested the hypothesis that implicit self-esteem would influence depression-related memory biases via its association with explicit self-esteem. Self-esteem was assessed in pati...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.003
更新日期：2016-08-30 00:00:00
abstract：:Diminished facial expressivity is a common feature of schizophrenia that interferes with effective interpersonal communication. This study was designed to determine if real-time visual feedback improved the ability of patients with schizophrenia to imitate and produce modeled facial expressions. Twenty patients with s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.12.007
更新日期：2006-12-07 00:00:00
abstract：:To evaluate the influence of weight loss on the dexamethasone suppression test (DST), we studied 61 patients with major depressive disorder as defined by the Research Diagnostic Criteria, 59 healthy normal volunteers, and 16 volunteers who lost weight by dieting. Nonsuppression on the DST was not correlated to weight ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90015-5
更新日期：1984-06-01 00:00:00
abstract：:The study aims to establish the concordant validity of the Early Detection Primary Care Checklist (PCCL); a 20 item tool designed to help primary care practitioners identify young people in the early stages of psychosis. The checklist was completed by the referring practitioners of 176 young people referred to early d...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.07.040
更新日期：2012-12-30 00:00:00
abstract：:At the beginning of the 2020 New year, novel coronavirus infection continues to affect our lives. The anxiety and stress caused by rising epidemic data, the helplessness and fear caused by city closure and isolation, and the boredom and irritability caused by extended holiday grounding all have a great impact on the p...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2020.113043
更新日期：2020-04-29 00:00:00
abstract：:The aim of the present work was to investigate if insomnia in late pregnancy is a risk factor for postpartum depressive symptomatology/postpartum depression (PPD). 581 women in their last trimester of pregnancy answered questions/questionnaires about lifetime history of insomnia, current sleep perception, current mood...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.06.029
更新日期：2011-04-30 00:00:00
abstract：:This study examined the impact of bombing on posttraumatic stress disorder (PTSD) and psychiatric co-morbidity over time, whether this relationship was mediated by shattered world assumptions and altered self-capacities, and whether the mediational effects were moderated by attachment style and crisis support among Ir...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.001
更新日期：2019-03-01 00:00:00
abstract：:Cognitive empathy impairments have been linked to poor social functioning in schizophrenia. However, prior studies primarily used self-reported empathy measures developed decades ago that are not well-aligned with contemporary models of empathy. We evaluated empathy and its relationship to social functioning in schizo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.054
更新日期：2014-09-04 00:00:00
abstract：:The aim of the present study was the validation of the Acquired Capability for Suicide Scale-Fearlessness about Death (ACSS-FAD) in a large population sample to further establish its reliability and validity, and to provide norm values. We assessed the ACSS-FAD, measures of depression, history of suicidal behavior, an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.052
更新日期：2016-04-30 00:00:00
abstract：:The present study explored minor physical anomaly items relevant to schizophrenia in order to establish a scale that can distinguish schizophrenia from controls using newly identified items along with items from the refined Waldrop scale. Seven items were significantly more frequent among schizophrenia patients (N=218...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.10.013
更新日期：2006-12-07 00:00:00
abstract：:We examined the executive control of emotional information and its relationship to social functioning in individuals at risk for schizophrenia, defined by high social anhedonia (SA). Using the same structure as the Attentional Network Test (ANT), we developed a measure of executive control of emotional information (AN...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.12.023
更新日期：2012-05-15 00:00:00
abstract：:Although social skills training (SST) is an effective approach for improving social skills for schizophrenia, the motivational deficit attenuates its efficacy. Virtual reality (VR) applications have allowed individuals with mental disabilities to enhance their motivation for rehabilitation. We compared SST using VR ro...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2011.04.003
更新日期：2011-09-30 00:00:00
abstract：:Trait anxiety, a personality dimension, has been characterized by functional consequences such as increased distractibility, attentional bias in favor of threat-related information and hyper-responsive amygdala. However, literature on the association between resting state brain functional connectivity, as studied usin...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.07.006
更新日期：2015-10-30 00:00:00
abstract：:Structural neuroimaging studies of the amygdala and hippocampus in bipolar disorder have been largely inconsistent. This may be due in part to differences in the proportion of subjects taking lithium or experiencing an acute mood state, as both factors have recently been shown to influence gray matter structure. To av...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.08.002
更新日期：2013-03-30 00:00:00
abstract：:This study explored in a non-clinical sample the associations between self-esteem, anxiety and depression symptoms and metacognitive awareness or metacognitive knowledge. Higher metacognitive awareness scores measured during the neuropsychological tasks were positively associated with higher depression scores in the s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.10.035
更新日期：2015-12-15 00:00:00
