Abstract：
:Serum neuroleptic levels, prolactin levels, and clinical state were assessed for 1 year in 29 schizophrenic outpatients whose clinically determined neuroleptic dose had been reduced by 50%. Fifty-five percent of the subjects remained stable. Neuroleptic dose did not differ between relapsed and stable patients. Serum prolactin (PRL) assessed 2 weeks after dose reduction and mean PRL after reduction were significantly lower among relapsers. Serum neuroleptic levels were significantly lower for relapsers in patients on haloperidol. Among relapsers, there were no serum PRL or neuroleptic level differences between stable periods and the relapse episode. Among patients with relatively low neuroleptic bioavailability, relapsers reported lower levels of social activity and had social networks that were less enjoyable, more aversive, and less helpful than those of stable patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Faraone SV,Curran JP,Laughren T,Faltus F,Johnston R,Brown WAdoi
10.1016/0165-1781(86)90124-1subject
Has Abstractpub_date
1986-12-01 00:00:00pages
311-22issue
4eissn
0165-1781issn
1872-7123pii
0165-1781(86)90124-1journal_volume
19pub_type
杂志文章abstract：:Computed axial brain tomograms were recorded in four groups of subjects: (a) subjects who had never taken benzodiazepines (n = 25); (b) subjects who had taken them in the past for less than a year (n = 9); (c) patients currently taking benzodiazepines (n = 30); and (d) patients who had taken benzodiazepines in the pas...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90037-h
更新日期：1993-08-01 00:00:00
abstract：:Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative approach where ED symptoms do not reflect an inferred, unobservable c...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.027
更新日期：2018-04-01 00:00:00
abstract：:The aim of this paper is to extensively review the current literature available on N-acetylcysteine (NAC) treatment for cocaine dependence (clinical and experimental studies). We screened all articles published before February 2016 reporting on the use of NAC as a pharmacological intervention for cocaine dependence or...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2017.02.024
更新日期：2017-05-01 00:00:00
abstract：:Hypersensitivity to sensory stimulation is a prominent characteristic of both schizophrenia and mania. Neurophysiological recordings suggest a common deficit in a central neuronal sensory gating mechanism which regulates sensitivity to repeated auditory stimuli. Dopamine and norepinephrine are hypothesized to have maj...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90099-q
更新日期：1990-03-01 00:00:00
abstract：:Klinefelter syndrome (47, XXY) is a sex chromosome aneuploidy associated with mild deficits in cognitive and language functions. Dysfunctions have also been reported in performance of tasks which examine executive functions. However, it is unclear whether the impaired performance is caused or accentuated by problems w...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.02.028
更新日期：2011-08-30 00:00:00
abstract：:Recent research has distinguished between anticipatory and consummatory pleasure. In the current study, we examined the psychometric properties of the Temporal Experience of Pleasure Scale (TEPS) to determine whether reliability and validity findings reported in previous research replicate in an additional sample of s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.01.012
更新日期：2011-05-15 00:00:00
abstract：:Bipolar disorder (BD) is associated with cognitive deficits in attention, verbal memory and executive functions. However, only few studies have examined sex effects on cognition despite their clinical relevance. Given that visual memory/ learning has been understudied the aim of our study was to investigate sex-relate...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.06.037
更新日期：2018-09-01 00:00:00
abstract：:The present study sought to identify factors associated with the onset of a manic or hypomanic episode during the month following a new antidepressant therapy in depressed bipolar patients. Patients receiving mood stabilizers for ≥3 months were screened from 400 French centers and were assessed for a 4-week period fol...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.04.071
更新日期：2016-06-30 00:00:00
abstract：:Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00128-1
更新日期：2000-02-14 00:00:00
abstract：:Patients with schizophrenia show dysfunction in sustained attention and facial emotion processing. We investigated the interplay between sustained attention and emotion by presenting emotional faces as background during AX-CPT in patients with schizophrenia. Nineteen schizophrenia patients and 21 healthy control subje...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.11.007
更新日期：2011-05-15 00:00:00
abstract：:Faces are often used in psychological and neuroimaging research to assess perceptual and emotional processes. Most available stimulus sets, however, represent minimal diversity in both race and ethnicity, which may confound understanding of these processes in diverse/racially heterogeneous samples. Having a diverse st...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.04.066
更新日期：2018-12-01 00:00:00
abstract：:Methamphetamine (METH) users showed structural and chemical abnormalities on magnetic resonance (MRI) studies, particularly in the frontal and basal ganglia brain regions. Diffusion tensor imaging (DTI) may provide further insights regarding the microstructural changes in METH users. We investigated diffusion tensor m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.03.011
更新日期：2009-10-30 00:00:00
abstract：:Schema theory and therapy may be an additional therapeutic approach to identify and treat chronic psychological problems, namely early maladaptive schemas (EMSs), in patients with obsessive-compulsive disorder (OCD) and panic disorder (PAD). In the current study, we investigated the characteristics in EMSs between pat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.015
更新日期：2015-12-30 00:00:00
abstract：:Biopterin, neopterin and the large neutral amino acids (LNAA), i.e. phenylalanine, tyrosine, tryptophan, isoleucine, leucine and valine were measured in plasma of 20 severely depressed inpatients before and after a course of electroconvulsive therapy (ECT). These patients showed a significantly lower plasma biopterin ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00282-7
更新日期：2001-09-20 00:00:00
abstract：:This study was designed to determine the effects of aging on the volume of the basal ganglia in individuals with Down syndrome (DS) and to examine the relationship between basal ganglia volumes, neuropsychological test performance, and dementia status in this population. Subjects were 32 adults with DS. Basal ganglia ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(97)00011-5
更新日期：1997-05-16 00:00:00
abstract：:Medication non-adherence is one of the major obstacles to recovery in first-episode psychosis (FEP). This study aimed to identify the predictors and rates of medication non-adherence in the first and second year after the start of treatment (baseline) in urban Chinese FEP patients. Relevant information on medication n...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.04.047
更新日期：2015-08-30 00:00:00
abstract：:In a pilot study, affective components of pain were assessed using repetitive peripheral magnetic stimulation (rPMS) in patients with borderline personality disorder and healthy controls. Significant differences in pain thresholds and in affective components of pain between both groups were found. rPMS was well tolera...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.07.050
更新日期：2011-04-30 00:00:00
abstract：:Conduct disorder (CD) symptom counts in preadolescent boys, and antisocial personality disorder (ASP) and childhood conduct disorder symptom counts in their parents, were used as dimensional measures of behavioral deviation. A significant correlation was found for CD and ASP symptom counts between the two parents and ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90003-y
更新日期：1993-01-01 00:00:00
abstract：:Benzodiazepines are frequently long-term prescribed for the treatment of patients with severe mental illness. This prescribing practice is problematic because of well-described side effects including risk of dependence. We examined the efficacy of prolonged-release melatonin on objective and subjective sleep quality d...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2016.04.031
更新日期：2016-06-30 00:00:00
abstract：:The lack of social contacts may be an important element in the presumed vicious circle aggravating, or at least stabilising negative symptoms in patients with schizophrenia. A European 2-year cohort study collected negative symptom scores, psychosocial functioning scores, objective social contact frequency scores and ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.039
更新日期：2015-12-30 00:00:00
abstract：:The current study aimed to explore Israelis' state anxiety due to a Syrian-Israeli incident that occurred on February 10, 2018, when an Israeli F-16 fighter jet was shot down by Syrian air defense forces. In line with the "looming vulnerability" model which emphasizes the importance of the dynamic nature of psychologi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.10.072
更新日期：2018-12-01 00:00:00
abstract：:Little is known about predictors of initiation and completion of evidence-based psychotherapy (EBP) for posttraumatic stress disorder (PTSD), with most data coming from small cohort studies and post-hoc analyses of clinical trials. We examined patient and treatment factors associated with initiation and completion of ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.02.027
更新日期：2019-04-01 00:00:00
abstract：:We have studied fasting plasma tryptophan (TRP) levels and tryptophan/large neutral amino acid (TRP/LNAA) ratios in 12 patients with obsessive-compulsive disorder (OCD) and 12 patients with OCD and a coexisting current diagnosis of major depressive disorder (OCD-MDD). Assessments were made at baseline and after 6 week...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(96)02961-7
更新日期：1997-03-03 00:00:00
abstract：:Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) dur...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.10.022
更新日期：2018-12-01 00:00:00
abstract：:Many Indian COVID-19 suicide cases are turning the press-media attention and flooding in the social media platforms although, no particular studies assessed the COVID-19 suicide causative factors to a large extent. Therefore, the present study presents 69 COVID-19 suicide cases (aged 19 to 65 years; 63 cases were male...
journal_title：Psychiatry research
pub_type： 信件
doi：10.1016/j.psychres.2020.113145
更新日期：2020-08-01 00:00:00
abstract：:Nearly all self-report measures of anhedonia have been developed for use in adults. Recently we developed an age and developmentally appropriate measure of social/interpersonal pleasure for adolescents (ACIPS-A), whereby lower scores are indicative of social anhedonia. However the scale had not been administered to Ea...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.007
更新日期：2017-11-01 00:00:00
abstract：:Diminished facial expressivity is a common feature of schizophrenia that interferes with effective interpersonal communication. This study was designed to determine if real-time visual feedback improved the ability of patients with schizophrenia to imitate and produce modeled facial expressions. Twenty patients with s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.12.007
更新日期：2006-12-07 00:00:00
abstract：BACKGROUND:The current COVID-19 pandemic and the consequent containment measures are leading to increasing mental health issues both in psychiatric patients and general population. OBJECTIVE:We aimed to compare the number and characteristics of emergency psychiatric consultations during the phase 1 of lockdown with re...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113463
更新日期：2020-11-01 00:00:00
abstract：:Glucocorticoids are known to modulate memory functions, with elevated cortisol levels being associated with impaired declarative memory. This specific effect has been shown in several studies using pharmacological doses of cortisol. The present study was designed to assess the effects of stress-induced cortisol elevat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.11.007
更新日期：2005-04-30 00:00:00
abstract：:Twenty-three patients meeting DSM-III criteria for agoraphobia with panic attacks and 14 age-, race-, and sex-matched nonanxious controls were tested in the laboratory and on a test walk in a shopping mall. The patients were tested before and after about 15 weeks of treatment with placebo and exposure therapy, imipram...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(88)90145-x
更新日期：1988-04-01 00:00:00
