Abstract：
:Patients with schizophrenia show dysfunction in sustained attention and facial emotion processing. We investigated the interplay between sustained attention and emotion by presenting emotional faces as background during AX-CPT in patients with schizophrenia. Nineteen schizophrenia patients and 21 healthy control subjects participated. We presented AX-CPT number stimuli superimposed on the nose of background facial expressions (happy, neutral or sad) over three experimental blocks for each emotion. Signal detection sensitivity (A') and reaction time were measured. Patients showed a steeper sensitivity decline when happy faces (compared with sad faces) were presented as background stimuli. By contrast, controls' sensitivity was not affected by the background facial emotion stimuli. Across the emotion conditions, the decline of sensitivity over time was evident in patients, but not in controls. To our knowledge, the present study is the first to explore a change in sustained attention accompanied by simultaneous processing of emotional faces in schizophrenia patients. Our findings suggest that mechanisms underlying continuous performance test (CPT) performance decline over time and facial emotion deficit may interact with each other in patients with schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Park SH,Kim JJ,Kim CH,Kim JH,Lee KHdoi
10.1016/j.psychres.2010.11.007subject
Has Abstractpub_date
2011-05-15 00:00:00pages
18-23issue
1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(10)00697-9journal_volume
187pub_type
杂志文章abstract：:Deficit and non-deficit subtypes were examined for their concordance in 83 sibling pairs of 109 schizophrenic patients belonging to 46 multiply affected families. Using a sib-pair method, we have found that the distribution of deficit and non-deficit syndromes in sibling pairs of schizophrenic patients differed signif...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00248-7
更新日期：2001-05-10 00:00:00
abstract：:The aim of this study was to gain a better understanding of schizophrenia patients' strategic use of learning time allocation during encoding, and determine whether they are able to use their monitoring and previous performances to adapt their learning behavior efficiently. Schizophrenia is considered to be a patholog...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.07.036
更新日期：2012-01-30 00:00:00
abstract：:Patients with Alzheimer's disease (AD) and schizophrenia display cognitive, behavioural disturbances and morphological abnormalities. Although these latter reflect progressive neurodegeneration in AD, their significance in schizophrenia is still unclear. We explored the patterns of hippocampal and amygdalar atrophy in...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.12.015
更新日期：2011-05-31 00:00:00
abstract：:Abnormalities of both the spontaneous and the stimulated release of growth hormone (GH) have been described in patients with endogenous depression. In this study, six unmedicated male patients with endogenous depression (ICD 296.1/3) were compared with six age-matched healthy men. Levels of GH were determined at 15-mi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90080-z
更新日期：1993-06-01 00:00:00
abstract：OBJECTIVE:Paliperidone, a second-generation antipsychotic, has been found to have minimal hepatotoxicity in patients with schizophrenia. However, long-term hepatic outcome in patients with schizophrenia and viral hepatitis remains unclear. METHODS:Data obtained from the Taiwan National Health Insurance Research Databa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112597
更新日期：2019-11-01 00:00:00
abstract：:Presynaptic dopamine metabolism was studied in a group of patients with schizophrenia and in an age- and gender-matched normal control group using 6-[(18)F]fluoro-L-DOPA ((18)F-DOPA) and positron emission tomography (PET). Nineteen patients, nine drug-free, 10 on neuroleptics, and 13 normal control subjects underwent ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(00)00064-0
更新日期：2000-11-20 00:00:00
abstract：:B cell lymphoma protein-2 (Bcl-2) may contribute to the pathophysiology of bipolar disorder, and may be involved in the therapeutic action of anti-manic drugs. The aim of this study was to investigate serum levels of Bcl-2 in bipolar patients in a manic phase, and evaluate the Bcl-2 changes after treatment. We consecu...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.12.020
更新日期：2015-02-28 00:00:00
abstract：:Obesity depends on homeostatic and hedonic food intake behavior, mediated by brain plasticity changes in cortical and subcortical structures. The aim of this study was to investigate cortical thickness and subcortical volumes of regions related to food intake behavior in a healthy young adult sample with obesity. Thir...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.06.004
更新日期：2013-11-30 00:00:00
abstract：:The phosphoinositide 3 kinase - protein kinase B (PI3K-Akt) signaling pathway plays an important role in the dopamine D2 receptor (DRD2) pathway and in the pathophysiology of schizophrenia. This study measured the mRNA levels of DRD2, PI3KCB, and AKT1 in peripheral blood samples from 24 acute schizophrenia patients an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.07.010
更新日期：2016-09-30 00:00:00
abstract：:In the search for a less expensive alternative to magnetic resonance imaging (MRI), which is contraindicated in some patients, we evaluated the accuracy of an individualized MR template-based head model in terms of navigated brain stimulation system targeting. The mean error between the identification of target points...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2011.12.013
更新日期：2012-07-30 00:00:00
abstract：:Several studies have found a positive relationship between cyberbullying victimization and psychiatric symptoms such as depression or anxiety. However, relatively little research has investigated factors that might moderate this association. The present study aimed to examine the moderating role of anger rumination, u...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.08.001
更新日期：2018-10-01 00:00:00
abstract：:This study had three aims: to compare a schizophrenia sample (n = 50) with a substance abuse (n = 25) and normal sample (n = 81) on affect recognition; to compare differences in their performance between positive and negative affect recognition; and to introduce a new videotape method of stimulus presentation. Subject...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(97)00111-x
更新日期：1997-11-14 00:00:00
abstract：:This report examines prognostic implications of neuropsychological deficit for clinical symptomatic improvement. Neuropsychological performance levels are related to the Brief Psychiatric Rating Scale thinking disturbance, paranoid disturbance, withdrawal/retardation, and anxiety/depression scales at hospital admissio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90072-8
更新日期：1994-06-01 00:00:00
abstract：:We examined the short-term efficacy of two treatments using environmental supports (e.g. signs, alarms, pill containers, and checklists) to improve target behaviors in individuals with schizophrenia. 120 participants were randomized into one of the following three treatment groups: 1) Cognitive Adaptation Training (CA...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2008.03.016
更新日期：2009-07-30 00:00:00
abstract：:Many young adults who attempt suicide have no discernible mental illness, suggesting an etiology distinct from other psychiatric disorders. Neurological anomalies associated with a history of suicidal behavior may predict future risk. In the present study, we explored changes in neural circuit organization associated ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.10.011
更新日期：2015-02-28 00:00:00
abstract：:Reduction of volume and neuronal number has been found in several association nuclei of the thalamus in schizophrenic subjects. Recent evidence suggests that schizophrenic patients exhibit abnormalities in early visual processing and that many of the observed perceptual deficits are consistent with dysfunction of the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.11.003
更新日期：2007-05-30 00:00:00
abstract：:In schizophrenia, psychomotor slowing and stereotypy are poorly delineated from cognitive deficits like diminished processing speed. Inpatients' performance outcomes on a line-copying task, a task assessing stereotypy and a processing-speed task are compared. Results suggested that psychomotor slowing and stereotypy a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.01.017
更新日期：2008-10-30 00:00:00
abstract：:The relationship between personality, as measured by selected clinical scales of the Minnesota Multiphasic Personality Inventory (MMPI) (Hypochondriasis, Depression, Hysteria, Psychasthenia, Social Introversion, and Anxiety) and the Anxiety Sensitivity Index (ASI), and behavioral response to the panicogenic agent chol...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(96)02819-3
更新日期：1996-05-17 00:00:00
abstract：:The aim of this study was to determine the differences in personality traits between individuals with Major Depressive Disorder (MDD) and Bipolar Disorder (BD) during a depressive episode, when it can be hard to differentiate them. Data on personality traits (NEO-FFI), mental disorders (Mini International Neuropsychia...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.12.029
更新日期：2016-02-28 00:00:00
abstract：:Resting state functional magnetic resonance imaging (fMRI) examines the spontaneous low frequency neural activity of the brain to reveal networks of correlated neural activity. A number of different methodologies, each with its own advantages and disadvantages, have been used to examine networks of neural activity tha...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.pscychresns.2014.10.003
更新日期：2014-12-30 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is a severe psychiatric disorder prevalent in combat veterans. Previous neuroimaging studies have demonstrated that patients with PTSD exhibit abnormal responses to non-threatening visual and auditory stimuli, but have not examined somatosensory processing. Thirty male combat veter...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.06.012
更新日期：2015-08-30 00:00:00
abstract：:Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.083
更新日期：2017-12-01 00:00:00
abstract：:Childhood trauma has been shown to increase the risk of suicide attempts in individuals with schizophrenia. However, previous literature has been limited by considerable heterogeneity within the category of suicide attempters. Here we tested the predictive effect of childhood maltreatment on lifetime suicide attempt i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112567
更新日期：2019-11-01 00:00:00
abstract：:Bipolar disorder (BD) adversely affects daily activities/functioning. The Sheehan Disability Scale (SDS) assesses disability in work/school activities, family relationships, and social functioning, and it evaluates the functional impact of psychiatric disorders. BD outpatients from 21 U.S. sites completed a battery of...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.11.018
更新日期：2009-01-30 00:00:00
abstract：:The present French-German cooperative study focuses on the genotype-phenotype relationship of mutations of the FMR-1 gene and psychiatric conditions in mothers with a full mutation in the FMR-1 gene of fra-X children (n=13), mothers with a premutation in the FMR-1 gene of fra-X children (n=61), as well as premutated s...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(98)00055-9
更新日期：1998-08-17 00:00:00
abstract：:The back-to-back (BTB) acquisition of MP-RAGE MRI scans of the Alzheimer׳s Disease Neuroimaging Initiative (ADNI1) provides an excellent data set with which to check the reproducibility of brain atrophy measures. As part of ADNI1, 131 subjects received BTB MP-RAGEs at multiple time points and two field strengths of 3T...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.07.002
更新日期：2014-10-30 00:00:00
abstract：:Conduct disorder is characterized by both habitual aggression as well as non-aggressive rule-breaking behavior. While a large body of research has focused on aggressive behavior to date, the subtype of non-aggressive rule-breaking behavior is poorly understood. The current study represents a first attempt to directly ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：:Recent neuroimaging studies have suggested that different symptom dimensions are mediated by partially distinct neural systems in obsessive-compulsive disorder (OCD). However, the correlations between neuropsychological profiles and symptom dimensions in OCD are unknown. The aim of this study was to examine the extent...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.08.001
更新日期：2011-05-15 00:00:00
abstract：:Knowledge on associations between ultra-high risk (UHR) for developing psychosis and on non-psychotic psychopathology in help-seeking populations is limited with respect to differences between male and female patients. The present study tests the hypothesis that both social anxiety and depression are highly prevalent ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.01.012
更新日期：2013-10-30 00:00:00
abstract：:The object of this study was to determine the reproducibility of the measurement of plasma catecholamine metabolites in normal control subjects and to assess the influence of factors such as time of day, diet, activity, blood pressure, and mood on the variance of these measures. Plasma free homovanillic acid (HVA), 3-...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90001-7
更新日期：1988-02-01 00:00:00
