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Influence of personality on behavioral response to cholecystokinin-tetrapeptide in patients with panic disorder.

Abstract：

:The relationship between personality, as measured by selected clinical scales of the Minnesota Multiphasic Personality Inventory (MMPI) (Hypochondriasis, Depression, Hysteria, Psychasthenia, Social Introversion, and Anxiety) and the Anxiety Sensitivity Index (ASI), and behavioral response to the panicogenic agent cholecystokinin-tetrapeptide (CCK-4) was examined in 29 patients with panic disorder with or without agoraphobia. Significant correlations were found between the MMPI Social Introversion scale and somatic, cognitive, and affective response to CCK-4. Both the MMPI Anxiety scale and the ASI correlated significantly with cognitive response to CCK-4, but not with somatic or affective response. None of the other selected MMPI clinical scales correlated with response to CCK-4. Multiple regression analyses identified the MMPI Social Introversion scale as the best predictor of all three indices of panic-anxiety induced by CCK-4. The results suggest that the relationship between neurotic introversion and sensitivity to CCK requires closer scrutiny.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Koszycki D,Zacharko RM,Bradwejn J

doi

10.1016/0165-1781(96)02819-3

subject

Has Abstract

pub_date

1996-05-17 00:00:00

pages

131-8

issue

2

eissn

0165-1781

issn

1872-7123

pii

0165-1781(96)02819-3

journal_volume

62

pub_type

杂志文章

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