Abstract：
:Chromosome 22q11.2 deletion syndrome (22q11DS) is associated with cognitive deficits and morphometric brain abnormalities in childhood and a markedly elevated risk of schizophrenia in adolescence/early adulthood. Determining the relationship between neurocognition and neuroimaging findings would yield crucial information about childhood neurodevelopment and provide a basis for the study of the trajectory that occurs on the pathway to psychosis. We compared morphometric brain findings between non-psychotic children with 22q11DS (n = 22) and healthy controls (n = 16), and examined the association between neurocognitive functioning and morphometric brain findings. Volumetric regional gray matter differences between the 22q11DS and control subjects were measured, and correlations of the regional gray matter volumes and neurocognition were performed. Children with 22q11DS demonstrated reductions in gray matter in several brain regions, chiefly the frontal cortices, the cingulate gyrus and the cerebellum. The volumetric reductions in these salient areas were associated with poor performance in sustained attention, executive function and verbal memory; however, the relation of brain volume with cognitive performance did not differ between the patient and control groups. Thus, children with 22q11DS demonstrate gray matter reductions in multiple brain regions that are thought to be relevant to schizophrenia. The correlation of these volumetric reductions with poor neurocognition indicates that these brain regions may mediate higher neurocognitive functions implicated in schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Shashi V,Kwapil TR,Kaczorowski J,Berry MN,Santos CS,Howard TD,Goradia D,Prasad K,Vaibhav D,Rajarethinam R,Spence E,Keshavan MSdoi
10.1016/j.pscychresns.2009.07.003subject
Has Abstractpub_date
2010-01-30 00:00:00pages
1-8issue
1eissn
0165-1781issn
1872-7123pii
S0925-4927(09)00168-1journal_volume
181pub_type
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