Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.

Abstract:

:Sherrington et al. (1988) reported linkage between markers located on the 5q11-q13 region of chromosome 5 and schizophrenia in five Icelandic and two British families. To date, however, all attempts to replicate the initial finding have failed. Using three markers of chromosome 5, we have studied 28 additional French pedigrees. When our data were analyzed both with parametric (i.e., lod scores) and nonparametric methods, we found no evidence of linkage. Thus, we were unable to replicate the earlier report by Sherrington et al.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Campion D,d'Amato T,Laklou H,Sabate O,Jay M,Leboyer M,Malafosse A,Gorwood P,Babron MC,Hillaire D

doi

10.1016/0165-1781(92)90021-t

subject

Has Abstract,Author List Incomplete

pub_date

1992-12-01 00:00:00

pages

171-9

issue

3

eissn

0165-1781

issn

1872-7123

pii

0165-1781(92)90021-T

journal_volume

44

pub_type

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