Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.


:Sherrington et al. (1988) reported linkage between markers located on the 5q11-q13 region of chromosome 5 and schizophrenia in five Icelandic and two British families. To date, however, all attempts to replicate the initial finding have failed. Using three markers of chromosome 5, we have studied 28 additional French pedigrees. When our data were analyzed both with parametric (i.e., lod scores) and nonparametric methods, we found no evidence of linkage. Thus, we were unable to replicate the earlier report by Sherrington et al.


Psychiatry Res


Psychiatry research


Campion D,d'Amato T,Laklou H,Sabate O,Jay M,Leboyer M,Malafosse A,Gorwood P,Babron MC,Hillaire D




Has Abstract,Author List Incomplete


1992-12-01 00:00:00














  • Behavioural dysregulation of decision-making in deficit but not nondeficit schizophrenia patients.

    abstract::This study aimed to determine whether deficit but not nondeficit schizophrenia showed dysregulation of decision-making. In a two-choice prediction task, the subject is asked to predict whether a stimulus appears on the left or right side of a computer screen. Schizophrenia patients were divided into 12 patients with a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Ludewig K,Paulus MP,Vollenweider FX

    更新日期:2003-08-01 00:00:00

  • Evidence of weekly cyclicity in mood and functional impairment in those with a bipolar disorder.

    abstract::A key characteristic of bipolar disorder is fluctuation in mood symptoms and functional capacity, yet assessment of bipolar symptomatology often relies heavily on interval measurement that is unable to capture the full range of daily symptom variability and severity. The current study provides a detailed analysis of t...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Proudfoot J,Whitton AE,Parker G,Manicavasagar V,Nicholas J,Smith M

    更新日期:2014-08-30 00:00:00

  • An investigation of the effect of social reciprocity, social anxiety, and letter fluency on communicative behaviors in adults with autism spectrum disorder.

    abstract::In recent years, research focusing on childhood has reported that communication difficulties in autism spectrum disorder (ASD) are related to the social reciprocity difficulties inherent to ASD, as well as severe social anxiety and decreased verbal fluency. However, there have been no reports regarding these correlati...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kimura Y,Fujioka T,Jung M,Fujisawa TX,Tomoda A,Kosaka H

    更新日期:2020-12-01 00:00:00

  • Personality variables modify the relationship between childhood maltreatment history and poor functional outcomes.

    abstract::Childhood maltreatment history is a prevalent risk factor for substance use disorder and has lifelong adverse consequences on psychiatric wellbeing. The role of personality variations in determining childhood maltreatment-associated outcomes is poorly understood. This study sought to test neuroticism and agreeableness...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Brents LK,James GA,Cisler JM,Kilts CD

    更新日期:2018-10-01 00:00:00

  • Differences of cerebral activation between superior and inferior learners during motor sequence encoding and retrieval.

    abstract::Cerebral activation during memory encoding and retrieval might depend on subjects' learning capacity, either by corresponding to better performance in superior learners or by reflecting increased effort in inferior learners. To investigate these alternative hypotheses, the study compared cerebral activation during enc...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Heun R,Freymann N,Granath DO,Stracke CP,Jessen F,Barkow K,Reul J

    更新日期:2004-11-15 00:00:00

  • Outcomes, moderators, and mediators of empathic-emotion recognition training for complex conduct problems in childhood.

    abstract::Impairments in emotion recognition skills are a trans-diagnostic indicator of early mental health problems and may be responsive to intervention. We report on a randomized controlled trial of "Emotion-recognition-training" (ERT) versus treatment-as-usual (TAU) with N=195 mixed diagnostic children (mean age 10.52 years...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


    authors: Dadds MR,Cauchi AJ,Wimalaweera S,Hawes DJ,Brennan J

    更新日期:2012-10-30 00:00:00

  • Behavioral changes in patients with mild senile dementia of the Alzheimer's type.

    abstract::Behavioral changes in 44 subjects with well-characterized mild senile dementia of the Alzheimer's type (SDAT) and 16 subjects with only questionable SDAT were compared to a control group of 58 subjects. Answers to both open-ended questions and personality items from the Blessed Dementia Scale were examined. Seventeen ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Rubin EH,Morris JC,Storandt M,Berg L

    更新日期:1987-05-01 00:00:00

  • Changes in serum miRNA-let-7 level in children with attention deficit hyperactivity disorder treated by repetitive transcranial magnetic stimulation or atomoxetine: An exploratory trial.

    abstract::We aimed to investigate whether microRNA-let-7d (miRNA-let-7d) and miRNA-107 may serve as diagnostic and therapeutic biomarkers of attention deficit hyperactivity disorder (ADHD). The relative expression level of miRNA-let-7d and miRNA-107 in patients with ADHD and in a healthy control group was detected by real-time ...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


    authors: Cao P,Wang L,Cheng Q,Sun X,Kang Q,Dai L,Zhou X,Song Z

    更新日期:2019-04-01 00:00:00

  • Effect of moderate weight loss on prolactin secretion in normal female volunteers.

    abstract::Sleep-related prolactin secretion and prolactin responses to the infusion of low doses of the dopamine antagonist, metoclopramide, and thyrotropin-releasing hormone were measured in 11 female volunteers before and after undertaking a diet in which they lost a mean of 3.1 kg in weight in 3 weeks. No effect of weight lo...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Anderson IM,Crook WS,Gartside SE,Parry-Billings M,Newsholme EA,Cowen PJ

    更新日期:1989-08-01 00:00:00

  • Assessing cognitive deficits in bipolar disorder: are self-reports valid?

    abstract::Patients with affective disorders frequently report problems with attention, concentration and memory, although little research has investigated subjective cognitive complaints relative to objective neuropsychological deficits. We compared subjective (self-rated) cognition and objective (clinician-rated) neuropsycholo...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Burdick KE,Endick CJ,Goldberg JF

    更新日期:2005-07-15 00:00:00

  • Visual attention in obsessive-compulsive disorder.

    abstract::Performance on neuropsychological tasks was compared in 15 subjects with obsessive-compulsive disorder (OCD) and 15 age- and sex-matched psychiatrically screened control subjects. The tasks chosen are known from studies in other patient groups to demonstrate lateralized abnormalities of visual and limited capacity att...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Nelson E,Early TS,Haller JW

    更新日期:1993-11-01 00:00:00

  • Test-performance after cognitive training in persons at risk mental state of schizophrenia and patients with schizophrenia.

    abstract::This exploratory study aims to examine the differential effects of a computer-based cognitive training in 'prodromal' patients (mean age 27.20 years, S.D. 5.31 years) compared with patients with full-blown schizophrenia (mean age 30.13 years, S.D. 7.77 years). Ten patients at risk for schizophrenia and 16 patients suf...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Rauchensteiner S,Kawohl W,Ozgurdal S,Littmann E,Gudlowski Y,Witthaus H,Heinz A,Juckel G

    更新日期:2011-02-28 00:00:00

  • The potential protective effects of cannabinoid receptor agonist WIN55,212-2 on cognitive dysfunction is associated with the suppression of autophagy and inflammation in an experimental model of vascular dementia.

    abstract::Vascular dementia (VaD) is characteristic of chronic brain ischemia and progressive memory decline, which has a high incidence in the elderly. However, there are no effective treatments for VaD, and the underlying mechanism of its pathogenesis remains unclear. This study investigated the effects of a synthetic cannabi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Wang DP,Yin H,Kang K,Lin Q,Su SH,Hai J

    更新日期:2018-09-01 00:00:00

  • Metabolic syndrome, depression and anhedonia among young adults.

    abstract::The aim of this study was to assess the association between anhedonia and metabolic syndrome (MetS) in a well-characterized community sample of individuals with a current depressive episode. This is a cross-sectional study with young adults aged 24-30 years old. Depressive episode and the presence of anhedonia was ass...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Moreira FP,Jansen K,Cardoso TA,Mondin TC,Vieira IS,Magalhães PVDS,Kapczinski F,Souza LDM,da Silva RA,Oses JP,Wiener CD

    更新日期:2019-01-01 00:00:00

  • Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.

    abstract::We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Marsh AA,Finger EC,Fowler KA,Jurkowitz ITN,Schechter JC,Yu HH,Pine DS,Blair RJR

    更新日期:2011-12-30 00:00:00

  • Destination memory in schizophrenia: "Did I told Elvis Presley about the thief?"

    abstract::Destination memory refers to the ability to remember to whom a piece of information was previously transmitted. Our paper assessed this ability in schizophrenia. Twenty-five patients with schizophrenia and 25 control participants told proverbs (e.g., "send a thief to catch a thief") to pictures of celebrities (e.g., E...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: El Haj M,Altman R,Bortolon C,Capdevielle D,Raffard S

    更新日期:2017-02-01 00:00:00

  • How do socio-demographic and clinical factors interact with adherence attitude profiles in schizophrenia? A cluster-analytical approach.

    abstract::Knowledge regarding socio-demographic and clinical risk factors of medication nonadherence does not always help in addressing adherence in individual patients. Classifying patients according to subjective adherence influencing factors may aid practitioners in choosing adequate strategies for improving medication adher...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Beck EM,Cavelti M,Wirtz M,Kossowsky J,Vauth R

    更新日期:2011-05-15 00:00:00

  • Aberrant functional connectivity of resting state networks associated with trait anxiety.

    abstract::Trait anxiety, a personality dimension, has been characterized by functional consequences such as increased distractibility, attentional bias in favor of threat-related information and hyper-responsive amygdala. However, literature on the association between resting state brain functional connectivity, as studied usin...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Modi S,Kumar M,Kumar P,Khushu S

    更新日期:2015-10-30 00:00:00

  • Relationship of defense styles with history of childhood trauma and personality in heroin dependent inpatients.

    abstract::In the present study the defense styles were assessed in heroin dependent inpatients to verify whether they used less adaptive defense mechanisms compared to healthy controls and to evaluate if immature defense styles are related with childhood traumas, while controlling the effect of age, temperament and character on...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Evren C,Ozcetinkaya S,Ulku M,Cagil D,Gokalp P,Cetin T,Yigiter S

    更新日期:2012-12-30 00:00:00

  • Using patient-reported outcome measures for program evaluation: Design and findings on intention-to-treat outcomes from the Veterans Outcome Assessment survey.

    abstract::The Veterans Outcomes Assessment (VOA) program surveys Veteran Health Administration (VHA) patients when they begin mental health treatment and at follow-up at three months to obtain patient-reported outcomes measures (PROM). It complements VA's evolving program in measurement-based care by providing additional data t...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Katz IR,Resnick SG,Kasprow WJ,Boden MT,Cherkasova E,Fielstein EM,Trafton JA,Hoff RA

    更新日期:2020-09-01 00:00:00

  • The effect of chronic physical illnesses on psychiatric hospital admission in patients with recurrent major depression.

    abstract::People with major depressive disorder (MDD) have an increased burden of chronic physical illnesses (CPI). However, information about the effect of CPIs on recurrent MDD treatment outcome is limited. The objective of this study was to explore whether the number of CPIs in patients with recurrent MDD was associated with...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Šimunović Filipčić I,Filipčić I,Glamuzina L,Devčić S,Bajić Ž,Braš M,Mihaljević Peleš A,Marčinko D,Sartorius N

    更新日期:2019-02-01 00:00:00

  • Normalization of auditory sensory gating in schizophrenic patients after a brief period for sleep.

    abstract::Diminished suppression of the P50 component of the evoked potential following repeated auditory stimuli is one example of a deficit in elementary sensory processing in schizophrenia. Normal subjects suppress the P50 evoked potential to the second of two paired auditory stimuli. Although normal P50 suppression is occas...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Griffith JM,Waldo M,Adler LE,Freedman R

    更新日期:1993-10-01 00:00:00

  • Is working memory intact in alcoholics? An ERP study.

    abstract::Few investigators have applied the working memory theory to studies on abstinent chronic alcoholics, though it has been reported that the deficits in short-term memory appear to be specific to visuo-spatial and problem-solving tasks. In the present study, we recorded ERPs from 40 male control subjects and 78 alcoholic...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Zhang XL,Begleiter H,Projesz B

    更新日期:1997-09-29 00:00:00

  • Event-related potentials elicited by distractors in an auditory oddball paradigm in schizophrenia.

    abstract::Patients with schizophrenia are affected more adversely than healthy controls by distracting conditions, due to their inability to adequately apportion attentional resources to targets or distractors. We attempted to re-evaluate the effects of distractors in 25 patients with chronic schizophrenia and in 12 controls. T...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kogoj A,Pirtosek Z,Tomori M,Vodusek DB

    更新日期:2005-11-15 00:00:00

  • Lithium transport in human fibroblasts: relationship to RBC lithium transport and psychiatric diagnoses.

    abstract::Cultured fibroblasts were prepared from six normal controls, five DSM-III manic patients, and six DSM-III schizophrenic patients. Lithium (Li+) uptake, 24-hour Li+ ratios, and steady-state membrane potential were measured in these cell lines. The uptake of 10 mM Li+ reached maximum at 2 hours, with an intracellular co...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Hitzemann R,Kao L,Hirschowitz J,Garver D,Gruenstein E

    更新日期:1988-06-01 00:00:00

  • Association between schizophrenia and Toxoplasma gondii infection in Algeria.

    abstract::Toxoplasmosis has been previously associated with an increased risk of having schizophrenia in several epidemiological studies. The aim of this prospective study was to examine for the first time a possible association between positive serology to Toxoplasma gondii (T. gondii) and schizophrenia in the Algerian populat...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kezai AM,Lecoeur C,Hot D,Bounechada M,Alouani ML,Marion S

    更新日期:2020-09-01 00:00:00

  • Are Schizophrenic disorders with or without early cannabis use neurobiologically distinct disease entities? A meta-analysis of magnetic resonance imaging studies.

    abstract::Cannabis use is considered an important risk factor for the development of psychotic illness and is associated with worse outcomes of the disorder. This study aimed to determine through a meta-analytic approach whether patients at the onset of schizophrenia with comorbid cannabis use (SCH CU+) show a different pattern...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Luca P,Rafael T,Emilio B,Antonio V

    更新日期:2021-01-16 00:00:00

  • Structural validation of The Patient Health Questionnaire-9 (PHQ-9) among Filipina and Indonesian female migrant domestic workers in Macao: STRUCTURAL VALIDATION OF PHQ-9.

    abstract::Within diverse global populations, validated tools are needed to assess common mental disorders. The Patient Health Questionnaire-9 (PHQ-9) is one of the most commonly used depression screeners. However, the PHQ-9 has not been structurally validated among female migrant domestic workers (MDWs). Female MDWs constitute ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Hall BJ,Patel A,Lao L,Liem A,Mayawati EH,Tjipto S

    更新日期:2021-01-01 00:00:00

  • Psychiatric patients' internet use corresponds to the internet use of the general public.

    abstract::The use of Internet has grown in the past number of years, including the increased application of various therapy programs for psychiatric patients which can be accessed online. Few studies investigating psychiatric patients' Internet use exist. Therefore, the aim of this study was to examine the number of psychiatric...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Trefflich F,Kalckreuth S,Mergl R,Rummel-Kluge C

    更新日期:2015-03-30 00:00:00

  • Alterations in local cerebral glucose utilization in rats after chronic amphetamine administration without subsequent challenge.

    abstract::The 2-deoxyglucose (2-DG) method was used to study regional metabolic changes in rats following chronic d-amphetamine treatment without subsequent challenges. Four groups of rats were pretreated (intraperitoneal administration) with d-amphetamine (0, 1, 5, or 10 mg/kg) once per day for 14 days. After a 7-day abstinenc...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Tsai SJ,Huang YH,Chang LS,Yang YC,Sim CB

    更新日期:1995-06-29 00:00:00