Abstract：
:Obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder characterized by intrusive thoughts and behaviors that dominate daily living, like an itch patients cannot ignore. Deficits in executive functioning are common in OCD and are thought to be related to dysfunctional frontal-striatal systems. One of those executive functions is cognitive flexibility, defined as the ability to rapidly switch response strategies following changes in task-relevant information. The temporal stability of cognitive flexibility impairments in OCD has been incompletely investigated since previous studies have suggested both state and trait dependency. In this study, 16 OCD patients performed a functional magnetic resonance imaging version of a task-switching paradigm twice, intervened by a follow-up period of on average 6 months. Results show that functional abnormalities in the dorsal frontal-striatal circuit and anterior cingulate cortex at baseline normalized at follow-up. This change in the recruitment of task-related brain circuits correlated with change in disease severity. These results support the view that the imbalance between the dorsal and ventral frontal-striatal circuits is at least partly state-dependent, and is associated with a reduction in symptom severity.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Vriend C,de Wit SJ,Remijnse PL,van Balkom AJ,Veltman DJ,van den Heuvel OAdoi
10.1016/j.pscychresns.2012.12.006subject
Has Abstractpub_date
2013-07-30 00:00:00pages
31-8issue
1eissn
0165-1781issn
1872-7123pii
S0925-4927(13)00002-4journal_volume
213pub_type
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