Abstract：
:Recent neuroimaging studies have suggested that different symptom dimensions are mediated by partially distinct neural systems in obsessive-compulsive disorder (OCD). However, the correlations between neuropsychological profiles and symptom dimensions in OCD are unknown. The aim of this study was to examine the extent to which OCD symptom dimensions were associated with episodic memory and attention and executive functions. The symptom dimensions of 63 patients with OCD were assessed using both the Padua Inventory and the Y-BOCS symptom checklist. Then, we administered the Logical Memory (LM) subset of the Wechsler Memory Scale-Revised (WMR-R) test and evaluated inhibition (Stroop test, Trail Making test) and cognitive flexibility (Digit Symbol test, Letter Fluency, and Category Fluency). While associations were observed between scores on the contamination/cleaning dimension and better performances on the LM and Trail Making tests, associations were also observed between scores on the aggressive/checking dimension and poorer performances on the Trail Making test. In addition, we found that scores on the symmetry/ordering dimension were associated with poorer performances on the LM and Trail Making tests. Our results support the hypothesis that different symptoms may represent distinct and partially overlapping neurocognitive networks in OCD patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hashimoto N,Nakaaki S,Omori IM,Fujioi J,Noguchi Y,Murata Y,Sato J,Tatsumi H,Torii K,Mimura M,Furukawa TAdoi
10.1016/j.psychres.2010.08.001subject
Has Abstractpub_date
2011-05-15 00:00:00pages
166-73issue
1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(10)00489-0journal_volume
187pub_type
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