Abstract：
:The purpose of this study was to investigate the influence of clozapine on plasma serotonin, platelet serotonin and monoamine oxidase (MAO) levels in schizophrenic patients and to compare their results with those of unmedicated healthy controls. Groups of 20 outpatients with schizophrenia and 20 healthy controls matched for age, sex and smoking status were recruited for the study. Psychopathology, neurocognitive functioning, plasma serotonin, platelet serotonin and MAO levels were assessed after 1-week drug free interval, and 8 weeks after initiation of clozapine treatment in an open design. The mean clozapine dose at week 8 was 382.5+/-96.4 (range: 250-600) mg/day. In the patient group, at baseline, plasma serotonin and platelet MAO levels were significantly lower, and platelet serotonin levels were significantly higher than in controls. After 8 weeks of clozapine treatment, plasma serotonin and platelet MAO levels increased significantly, while a significant decrease in platelet serotonin levels was detected compared with baseline values. Baseline platelet MAO levels explained 22% of the variance in Clinical Global Impression - Improvement (CGI-I) and improvement in attention, while baseline platelet serotonin predicted 23% of the variance in the improvement in positive symptoms during clozapine treatment. Our data indicate that clozapine may be reversing or compensating for a pre-existing alteration in serotonergic neurotransmission in schizophrenic patients. The prediction of response to clozapine through peripheral biochemical markers may have important clinical implications if repeated in larger samples.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Ertugrul A,Ucar G,Basar K,Demir B,Yabanoglu S,Ulug Bdoi
10.1016/j.psychres.2005.12.009subject
Has Abstractpub_date
2007-01-15 00:00:00pages
49-57issue
1-3eissn
0165-1781issn
1872-7123pii
S0165-1781(06)00003-5journal_volume
149pub_type
临床试验,杂志文章abstract：:We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2013.05.017
更新日期：2013-10-30 00:00:00
abstract：:Six schizophrenic patients had their urinary peptide levels measured before and after 5 weeks of treatment with neuroleptic medications. For two patients, levels were also measured after a reduction in the neuroleptic dose. Because of the heterogeneity of peptide peaks with the same bioactivity, the overall peptide le...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02629-b
更新日期：1995-09-29 00:00:00
abstract：:Several recent studies in animals and man indicate that corticosteroids may alter catecholaminergic activity in both the peripheral and central nervous systems. We administered 1 mg of the synthetic glucocorticoid, dexamethasone, to 12 drug-free healthy volunteers and measured plasma homovanillic acid (HVA) and 3-meth...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(85)90003-4
更新日期：1985-10-01 00:00:00
abstract：:The primary aim of the present study was to assess the possible associations between dopaminergic, serotonergic, and glutamatergic system-related genes and adverse events after antipsychotic treatment in paranoid schizophrenia patients. The second aim of the study was to compare the intensity of these symptoms between...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2014.05.039
更新日期：2014-10-30 00:00:00
abstract：:One inhalation of 35% CO2 in oxygen was administered to 36 patients with anxiety disorders and 14 healthy controls. Eighteen patients had a diagnosis of panic disorder (PD) and 18 of obsessive-compulsive disorder (OCD). As a placebo control for CO2, compressed air was administered in a double-blind design. Immediately...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90121-k
更新日期：1990-02-01 00:00:00
abstract：:The main goal of this study it is explore the psychopathological differences between IPD and SIPD in a sample of 125 adults with a lifetime diagnosis of cocaine disorder recruited from treatment setting and through street contacts. A secondary analysis of six cross-sectional studies was conducted between 2000 and 2010...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.05.043
更新日期：2016-08-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.psychres.2008.06.027
更新日期：2009-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.017
更新日期：2019-03-01 00:00:00
abstract：:This study measured changes in regional cerebral blood flow (rCBF) during the complex cognitive task of meditation using single photon emission computed tomography. Eight experienced Tibetan Buddhist meditators were injected at baseline with 7 mCi HMPAO and scanned 20 min later for 45 min. The subjects then meditated ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(01)00074-9
更新日期：2001-04-10 00:00:00
abstract：:We studied beta-adrenergic receptor binding, using 125I-cyanopindolol as the ligand, in the leukocyte membranes of depressed patients, schizophrenic patients, and normal control subjects during a drug-free period. We also determined plasma cortisol levels and dexamethasone suppression in these subjects. The maximum nu...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(87)90105-3
更新日期：1987-12-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.027
更新日期：2018-04-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.psychres.2018.01.006
更新日期：2018-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.02.001
更新日期：2009-05-30 00:00:00
abstract：:Evaluation of the outcomes of our decisions may instigate comparisons of our actual outcome with those of others (social comparisons) or comparisons with alternative outcomes of choices not made (private comparisons). Previous research has suggested a deficit in attention to social information among individuals with a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.01.036
更新日期：2014-05-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2004.01.002
更新日期：2004-05-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(92)90001-k
更新日期：1992-08-01 00:00:00
abstract：:This study aimed to evaluate the efficacy of a diet and exercise lifestyle intervention on mental health outcomes for patients currently being treated for depression and/or anxiety in primary care. Patients (n=119) referred by general practitioners to the 12-week randomised controlled trial were assigned to either an ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2015.10.001
更新日期：2015-12-15 00:00:00
abstract：:Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic p...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.07.034
更新日期：2013-12-30 00:00:00
abstract：:This study examines the association between suicidal ideation and sleep disturbances in a sample of treatment-seeking Canadian Forces members and veterans, after controlling for probable posttraumatic stress disorder (PTSD), major depressive disorder (MDD), generalised anxiety disorder (GAD), and alcohol use disorder ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.008
更新日期：2014-08-15 00:00:00
abstract：:To clarify the relationship between serum folate and schizophrenia (SZ) risk, the meta-analysis was conducted. PubMed, Embase, and Web of Science were searched without language restrictions. Weighted mean difference (WMD) as a summary statistic was used in this meta-analysis. Subgroup analyses by publication language ...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2015.11.045
更新日期：2016-01-30 00:00:00
abstract：:To determine the relationship between Tridimensional Personality Questionnaire (TPQ) scales and bulimia nervosa, TPQ scores of 27 bulimic women, age range 21-59, were compared with values for an age-matched sample of 128 normal control women drawn from the national norming sample by Przybeck. Scores for Novelty Seekin...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：:This school-based study aimed to investigate the prevalence of being at risk for depression, bullying behavior, and current smoking among Chinese adolescents in order to explore gender differences in the vulnerability of adolescents with these behaviors to develop a smoking habit. A total of 35,893 high school student...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.027
更新日期：2016-03-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.02.032
更新日期：2013-06-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.07.044
更新日期：2015-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(93)90057-n
更新日期：1993-04-01 00:00:00
abstract：:The relationship between levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) and symptom scores on the Hamilton Rating Scale for Depression was examined in 31 patients with unipolar depression. Patients with either low MHPG or high MHPG showed significant sleep disturbance in the form of early morning awakening. ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90035-3
更新日期：1994-02-01 00:00:00
abstract：:B cell lymphoma protein-2 (Bcl-2) may contribute to the pathophysiology of bipolar disorder, and may be involved in the therapeutic action of anti-manic drugs. The aim of this study was to investigate serum levels of Bcl-2 in bipolar patients in a manic phase, and evaluate the Bcl-2 changes after treatment. We consecu...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.12.020
更新日期：2015-02-28 00:00:00
abstract：:Attentional and executive impairments have been found both in patients with schizophrenia and in their unaffected first-degree relatives, suggesting that they might be considered as familial vulnerability markers. Several studies have shown that the performance of bipolar patients does not significantly differ from th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(03)00252-x
更新日期：2004-01-01 00:00:00
abstract：:Benzodiazepines are frequently long-term prescribed for the treatment of patients with severe mental illness. This prescribing practice is problematic because of well-described side effects including risk of dependence. We examined the efficacy of prolonged-release melatonin on objective and subjective sleep quality d...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2016.04.031
更新日期：2016-06-30 00:00:00
abstract：:Geriatric patients with dementia frequently present with agitation, aggression, psychosis, and other behavioral and psychological symptoms of dementia (BPSD). We present an update of our previously published algorithms for the use of psychopharmacologic agents in these patients taking into account more recent studies ...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2020.113641
更新日期：2021-01-01 00:00:00
