Abstract：
:B cell lymphoma protein-2 (Bcl-2) may contribute to the pathophysiology of bipolar disorder, and may be involved in the therapeutic action of anti-manic drugs. The aim of this study was to investigate serum levels of Bcl-2 in bipolar patients in a manic phase, and evaluate the Bcl-2 changes after treatment. We consecutively enrolled 23 bipolar inpatients in a manic phase and 40 healthy subjects; 20 bipolar patients were followed up with treatment. Serum Bcl-2 levels were measured with assay kits. All 20 patients were evaluated by examining the correlation between Bcl-2 levels and Young Mania Rating Scale (YMRS) scores, using Spearman׳s correlation coefficients. The serum Bcl-2 levels in bipolar patients in a manic phase were higher than in healthy subjects, but without a significant difference. The YMRS scores were significantly negatively associated with serum Bcl-2 levels (p=0.042). Bcl-2 levels of the 20 bipolar patients were measured at the end of treatment. Using the Wilcoxon Signed Rank test, we found no significant difference in the Bcl-2 levels of bipolar patients after treatment. Our results suggest that Bcl-2 levels might be an indicator of severity of manic symptoms in bipolar patients in a manic phase.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Chen WT,Huang TL,Tsai MCdoi
10.1016/j.psychres.2014.12.020subject
Has Abstractpub_date
2015-02-28 00:00:00pages
305-8issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(14)01013-0journal_volume
225pub_type
杂志文章abstract：:Somatosensory evoked potential (SEP) late waves (P400) associated with selective attention were elicited by having subjects count electrical stimuli to one of four randomly stimulated fingers. P400 amplitude was lower in a diagnostically heterogeneous group of 20 psychiatric patients than in 16 nonpatients. Among pati...
journal_title：Psychiatry research
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abstract：:Gender specific personality profiles in association with the level of aggressive antisocial behavior in offenders have not been previously investigated. In the present study we analyzed data collected from 65 male and 50 female offenders using structured protocols regarding criminal history (by criminal register data)...
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pub_type： 杂志文章,多中心研究
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1987-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析,评审
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