Abstract:
:The phosphoinositide 3 kinase - protein kinase B (PI3K-Akt) signaling pathway plays an important role in the dopamine D2 receptor (DRD2) pathway and in the pathophysiology of schizophrenia. This study measured the mRNA levels of DRD2, PI3KCB, and AKT1 in peripheral blood samples from 24 acute schizophrenia patients and 20 healthy controls using real-time quantitative reverse transcription polymerase chain reaction (real-time qRT-PCR). We found that in the acute schizophrenia patients, the mRNA expression levels of DRD2 and PI3KCB were significantly lower than those in the healthy controls, while the AKT1 mRNA levels were significantly higher than those in the healthy controls. A significant relationship between the mRNA levels of DRD2 and PI3KCB was found only in the controls. In conclusion, the gene expression state of the DRD2-PI3K-AKT signaling cascade differed significantly between acute schizophrenia patients and healthy controls.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Liu L,Luo Y,Zhang G,Jin C,Zhou Z,Cheng Z,Yuan Gdoi
10.1016/j.psychres.2016.07.010subject
Has Abstractpub_date
2016-09-30 00:00:00pages
397-402eissn
0165-1781issn
1872-7123pii
S0165-1781(15)30559-Xjournal_volume
243pub_type
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