Abstract：
:High affinity 3H-paroxetine binding was studied in human frontal cortex and hippocampus obtained from normal controls and alcoholics. On the basis of Scatchard analyses, a significant decrease in the maximal number of binding sites (Bmax) was found in the hippocampus of alcoholics (n = 8) as compared with that of controls (n = 10) (mean +/- SD = 63 +/- 35 vs. 114 +/- 70 fmoles/mg protein). There was no significant difference in the dissociation constants (Kd) between the two groups. The presumed effect of chronic alcohol abuse on 3H-paroxetine binding may be region-specific since no significant difference in either Bmax or Kd for 3H-paroxetine binding was found in the frontal cortex between normal controls and alcoholics. No significant correlation of 3H-paroxetine binding with age or postmortem interval was observed. The decrease in 3H-paroxetine binding in the hippocampus of alcoholics is probably indicative of reduced density of serotonergic nerve terminals either as a preexisting condition or as a result of neuronal damage caused by ethanol or the sequelae of alcoholism, such as nutritional deficiencies.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Chen HT,Casanova MF,Kleinman JE,Zito M,Goldman D,Linnoila Mdoi
10.1016/0165-1781(91)90019-lsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
293-9issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(91)90019-Ljournal_volume
38pub_type
杂志文章abstract：:The purpose of this study was to investigate the relationship between functional polymorphisms in genes coding for dopamine metabolism and transport enzymes and the incidence of acute antipsychotic (AP)-induced extrapyramidal symptoms (EPS). We did not find evidence of the involvement of these polymorphisms in the pre...
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更新日期：2010-01-30 00:00:00
abstract：:Wisconsin Card Sorting Test (WCST) performances were studied in 33 patients with obsessive-compulsive disorder (OCD) and 33 age-, sex-, and education-matched normal comparison subjects; the OCD patients were divided into four subgroups on the basis of their symptomatology. Neither the two groups of subjects nor the fo...
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更新日期：2008-04-15 00:00:00
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更新日期：2016-11-30 00:00:00
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更新日期：2004-06-30 00:00:00
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更新日期：2000-07-17 00:00:00
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更新日期：2004-08-30 00:00:00
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更新日期：2015-12-30 00:00:00
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更新日期：2005-07-15 00:00:00
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更新日期：1989-02-01 00:00:00
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更新日期：2015-10-30 00:00:00
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更新日期：2019-04-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Psychiatry research
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更新日期：2004-02-15 00:00:00
abstract：:Several recent studies in animals and man indicate that corticosteroids may alter catecholaminergic activity in both the peripheral and central nervous systems. We administered 1 mg of the synthetic glucocorticoid, dexamethasone, to 12 drug-free healthy volunteers and measured plasma homovanillic acid (HVA) and 3-meth...
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