Abstract：
:Although brain lactate levels are typically low and difficult to measure, a few previous investigators have reported that brain lactate levels are elevated in patients with bipolar disorder. The present study investigated the distribution of lactate in bipolar and healthy brains using 2D proton magnetic resonance spectroscopic imaging on a 4-Tesla magnetic resonance imaging system. Ratios of the concentration of lactate to N-acetylaspartate, and of lactate to total creatine, were significantly higher in bipolar than in healthy subjects. Lactate signals were primarily localized to the bipolar subjects' caudate and anterior cingulate cortices, components of the frontal-subcortical circuit, suggesting that affective dysregulation may be related to metabolic abnormalities in this network.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Chu WJ,Delbello MP,Jarvis KB,Norris MM,Kim MJ,Weber W,Lee JH,Strakowski SM,Adler CMdoi
10.1016/j.pscychresns.2013.03.004subject
Has Abstractpub_date
2013-09-30 00:00:00pages
230-4issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(13)00083-8journal_volume
213pub_type
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